Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis.

abstract：:TNF inhibitors are currently considered both effective and cost-effective in patients with active rheumatoid arthritis (RA), particularly in patients who have not responded fully to methotrexate. There is substantial doubt about the cost-effectiveness of TNF inhibitors as initial treatment for active RA. New data from...

journal_title：Arthritis research & therapy

authors： Scott DL,Kingsley G

更新日期：2010-01-01 00:00:00

abstract：:Synovial fluid from patients with various arthritides contains procoagulant, cell-derived microparticles. Here we studied whether synovial microparticles modulate the release of chemokines and cytokines by fibroblast-like synoviocytes (FLS). Microparticles, isolated from the synovial fluid of rheumatoid arthritis (RA)...

journal_title：Arthritis research & therapy

authors： Berckmans RJ,Nieuwland R,Kraan MC,Schaap MC,Pots D,Smeets TJ,Sturk A,Tak PP

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

journal_title：Arthritis research & therapy

authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of ...

journal_title：Arthritis research & therapy

authors： Happonen KE,Saxne T,Geborek P,Andersson M,Bengtsson AA,Hesselstrand R,Heinegård D,Blom AM

更新日期：2012-01-20 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

journal_title：Arthritis research & therapy

authors： Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

更新日期：2016-10-04 00:00:00

abstract：INTRODUCTION:Reconstitution of peripheral blood (PB) B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab (RTX) mimics lymphatic ontogeny. In this situation, the repletion kinetics and migratory properties of distinct developmental B-cell stages and their correlation to disease activity mi...

journal_title：Arthritis research & therapy

authors： Möller B,Aeberli D,Eggli S,Fuhrer M,Vajtai I,Vögelin E,Ziswiler HR,Dahinden CA,Villiger PM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

journal_title：Arthritis research & therapy

authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

更新日期：2018-04-10 00:00:00

abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

journal_title：Arthritis research & therapy

authors： Lundy SK,Fox DA

更新日期：2009-01-01 00:00:00

abstract：:Dysregulated psychophysiological responses have been observed in patients with fibromyalgia syndrome (FMS), although the results are inconsistent. Surface electromyographic (EMG), systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels (SCLs) were continuously recorded at baseline, and duri...

journal_title：Arthritis research & therapy

authors： Thieme K,Turk DC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：INTRODUCTION:Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sl...

journal_title：Arthritis research & therapy

authors： Lee YC,Chibnik LB,Lu B,Wasan AD,Edwards RR,Fossel AH,Helfgott SM,Solomon DH,Clauw DJ,Karlson EW

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell lines or monocytes of ...

journal_title：Arthritis research & therapy

authors： Mylona EE,Mouktaroudi M,Crisan TO,Makri S,Pistiki A,Georgitsi M,Savva A,Netea MG,van der Meer JW,Giamarellos-Bourboulis EJ,Joosten LA

更新日期：2012-07-04 00:00:00

abstract：BACKGROUND:Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF b...

journal_title：Arthritis research & therapy

authors： Estelius J,Lengqvist J,Ossipova E,Idborg H,Le Maître E,Andersson MLA,Brundin L,Khademi M,Svenungsson E,Jakobsson PJ,Lampa J

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. Cross-re...

journal_title：Arthritis research & therapy

authors： Deng H,Wang C,Chang DY,Hu N,Chen M,Zhao MH

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：INTRODUCTION:C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this study was to determine the role of CRP on bon...

journal_title：Arthritis research & therapy

authors： Kim KW,Kim BM,Moon HW,Lee SH,Kim HR

更新日期：2015-03-04 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：INTRODUCTION:The aims of this study were to evaluate the diagnostic accuracy of blood B-cell subset profiling and immune-system activation marker assays in primary Sjögren's syndrome (pSS) and to assess whether adding these tools to the current laboratory item would improve the American-European Consensus Group (AECG) ...

journal_title：Arthritis research & therapy

authors： Cornec D,Saraux A,Pers JO,Jousse-Joulin S,Marhadour T,Roguedas-Contios AM,Genestet S,Renaudineau Y,Devauchelle-Pensec V

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we measured changes in inter-relationships of plasma galectin-3, skel...

journal_title：Arthritis research & therapy

authors： Andonian BJ,Bartlett DB,Huebner JL,Willis L,Hoselton A,Kraus VB,Kraus WE,Huffman KM

更新日期：2018-12-27 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：INTRODUCTION:Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions in ECM degradation and prevents ECM synthesis by down-regulating the key transcription factor, Sox9, and consequently inhibiting ECM gene expressio...

journal_title：Arthritis research & therapy

authors： Dai L,Zhang X,Hu X,Zhou C,Ao Y

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype of RA-FLS and attenua...

journal_title：Arthritis research & therapy

authors： Pethő Z,Tanner MR,Tajhya RB,Huq R,Laragione T,Panyi G,Gulko PS,Beeton C

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS:Arthroscopic assessment of articular cartilage damage was performed twice ...

journal_title：Arthritis research & therapy

authors： Sobue Y,Kojima T,Kurokouchi K,Takahashi S,Yoshida H,Poole R,Ishiguro N

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype. METHODS:A total of 116 RA patients and 31 ag...

journal_title：Arthritis research & therapy

authors： Fujita Y,Asano T,Matsuoka N,Temmoku J,Sato S,Matsumoto H,Furuya MY,Suzuki E,Watanabe H,Kawakami A,Migita K

更新日期：2020-04-15 00:00:00

abstract：:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction distur...

journal_title：Arthritis research & therapy

authors： Fritsch C,Hoebeke J,Dali H,Ricchiuti V,Isenberg DA,Meyer O,Muller S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes during OA pathogenesis....

journal_title：Arthritis research & therapy

authors： Li J,Huang J,Dai L,Yu D,Chen Q,Zhang X,Dai K

更新日期：2012-04-16 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the disease contributing to joint damage is synovial hyperplasia. The factors responsible for the hyperplasia are u...

journal_title：Arthritis research & therapy

authors： Tu-Rapp H,Hammermüller A,Mix E,Kreutzer HJ,Goerlich R,Köhler H,Nizze H,Thiesen HJ,Ibrahim SM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:Autoreactive B cells are crucial players in the pathogenesis of rheumatoid arthritis (RA). Autoantibodies specific for citrullinated proteins (ACPA), present in the serum of approximately 60-70 % of patients, have a pathogenic role in the disease. B cell depleting therapies may result in a transient immunosu...

journal_title：Arthritis research & therapy

authors： Pozsgay J,Babos F,Uray K,Magyar A,Gyulai G,Kiss É,Nagy G,Rojkovich B,Hudecz F,Sármay G

更新日期：2016-01-16 00:00:00