Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis.

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might...

journal_title：Arthritis research & therapy

authors： Berthelot JM,Le Goff B,Maugars Y

更新日期：2019-11-13 00:00:00

abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

journal_title：Arthritis research & therapy

authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

journal_title：Arthritis research & therapy

authors： Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

journal_title：Arthritis research & therapy

authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

更新日期：2020-09-29 00:00:00

abstract：INTRODUCTION:Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic differences are particularly at...

journal_title：Arthritis research & therapy

authors： Wiese MD,Schnabl M,O'Doherty C,Spargo LD,Sorich MJ,Cleland LG,Proudman SM

更新日期：2012-07-12 00:00:00

abstract：INTRODUCTION:Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early RA and ...

journal_title：Arthritis research & therapy

authors： Renger F,Bang H,Feist E,Fredenhagen G,Natusch A,Backhaus M,Burmester GR,Egerer K

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Inflammatory arthritis is associated with increased bone resorption and suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation and this protein has been proposed to be a master regulator of bone remodelling in inflammatory arthritis. ...

journal_title：Arthritis research & therapy

authors： Hardy R,Juarez M,Naylor A,Tu J,Rabbitt EH,Filer A,Stewart PM,Buckley CD,Raza K,Cooper MS

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) in...

journal_title：Arthritis research & therapy

authors： He S,Liu X,Lin Z,Liu Y,Gu L,Zhou H,Tang W,Zuo J

更新日期：2019-01-29 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：:The article by Seror et al. in Arthritis Research & Therapy reports data from the 15 French patients in the open-label BELISS (Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome, NCT01160666) study of belimumab in primary Sjögren's syndrome. The study identifies that higher baseline levels of...

journal_title：Arthritis research & therapy

authors： Bowman SJ,Fisher BA

更新日期：2015-12-07 00:00:00

abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

journal_title：Arthritis research & therapy

authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support...

journal_title：Arthritis research & therapy

authors： Sato M,Uchida K,Nakajima H,Miyazaki T,Guerrero AR,Watanabe S,Roberts S,Baba H

更新日期：2012-02-07 00:00:00

abstract：INTRODUCTION:Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 + CXCR3-CCR6- (Tfh-Th2) and CXCR5 + CXCR3-CCR6+ (Tfh-Th17). Our objective was to study the B cell ...

journal_title：Arthritis research & therapy

authors： Arroyo-Villa I,Bautista-Caro MB,Balsa A,Aguado-Acín P,Bonilla-Hernán MG,Plasencia C,Villalba A,Nuño L,Puig-Kröger A,Martín-Mola E,Miranda-Carús ME

更新日期：2014-12-05 00:00:00

abstract：INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

journal_title：Arthritis research & therapy

authors： Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

更新日期：2014-10-31 00:00:00

abstract：INTRODUCTION:Data from clinical studies on the long-term efficacy and safety of anti-tumor necrosis factor (TNF)-α therapy in patients with ankylosing spondylitis (AS) are scarce. This is the first report on continuous treatment with the TNFα fusion protein etanercept over seven years (y). METHODS:Overall, 26 patients...

journal_title：Arthritis research & therapy

authors： Baraliakos X,Haibel H,Fritz C,Listing J,Heldmann F,Braun J,Sieper J

更新日期：2013-01-01 00:00:00

abstract：:Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of com...

journal_title：Arthritis research & therapy

authors： Cortes A,Brown MA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

journal_title：Arthritis research & therapy

authors： Jamian L,Wheless L,Crofford LJ,Barnado A

更新日期：2019-12-30 00:00:00

abstract：INTRODUCTION:Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the associatio...

journal_title：Arthritis research & therapy

authors： Schipper LG,Fransen J,den Broeder AA,Van Riel PL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:It is known that anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we studied ACPA-negative arthralgia patients who were considered prone to progress to RA for local sub...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Huizinga TW,Reijnierse M,van der Helm-van Mil AH

更新日期：2014-04-10 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：INTRODUCTION:The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. METHODS:Thirty-one female subjects with OA ...

journal_title：Arthritis research & therapy

authors： Helmark IC,Mikkelsen UR,Børglum J,Rothe A,Petersen MC,Andersen O,Langberg H,Kjaer M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA). METHODS:A self-reported questionnaire containing 12 items potentially relevant to PD and dentists' semiquantitative assessment of PD (no/mild/modera...

journal_title：Arthritis research & therapy

authors： Callhoff J,Dietrich T,Chubrieva M,Klotsche J,Zink A

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nu...

journal_title：Arthritis research & therapy

authors： TenBroek EM,Yunker L,Nies MF,Bendele AM

更新日期：2016-01-21 00:00:00

abstract：:Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular e...

journal_title：Arthritis research & therapy

authors： Nurmohamed MT

更新日期：2010-01-01 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was the evaluation of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (IA) tumor necrosis factor (TNF)-α blockers in psoriatic arthritis (PsA). METHODS:Systemic and lo...

journal_title：Arthritis research & therapy

authors： Fiocco U,Sfriso P,Oliviero F,Roux-Lombard P,Scagliori E,Cozzi L,Lunardi F,Calabrese F,Vezzù M,Dainese S,Molena B,Scanu A,Nardacchione R,Rubaltelli L,Dayer JM,Punzi L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:We sought to assess vascularity in wrist tenosynovitis by using power Doppler ultrasound (PDUS) and to compare detection of intra- and peritendinous vascularity with that of contrast-enhanced grey-scale ultrasound (CEUS). METHODS:Twenty-six tendons of 24 patients (nine men, 15 women; mean age ± SD, 54.4 ±...

journal_title：Arthritis research & therapy

authors： Klauser AS,Franz M,Arora R,Feuchtner GM,Gruber J,Schirmer M,Jaschke WR,Gabl MF

更新日期：2010-01-01 00:00:00

abstract：:Joint space width (JSW) and narrowing (JSN) measurements on radiographs are currently the best way to assess disease severity or progression in hip osteoarthritis, yet we lack data regarding the most accurate and sensitive measurement technique. This study was conducted to determine the optimal radiograph and number o...

journal_title：Arthritis research & therapy

authors： Maheu E,Cadet C,Marty M,Dougados M,Ghabri S,Kerloch I,Mazières B,Spector TD,Vignon E,Lequesne MG

更新日期：2005-01-01 00:00:00