Promise and pitfalls of the Immunochip.

abstract：INTRODUCTION:Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial cit...

journal_title：Arthritis research & therapy

authors： Makrygiannakis D,Revu S,Engström M,af Klint E,Nicholas AP,Pruijn GJ,Catrina AI

更新日期：2012-01-27 00:00:00

abstract：INTRODUCTION:Antibodies against citrullinated peptides (anti-CCP) and increased levels of cytokines precede the development of rheumatoid arthritis (RA) by several years. Recently, the proteins survivin and Fms-like tyrosine kinase 3 ligand (Flt3L) have been identified as biomarkers of RA associated with joint destruct...

journal_title：Arthritis research & therapy

authors： Bokarewa M,Brink M,Erlandsson M,Rantapää Dahlqvist S

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Clinical remission can be maintained after the discontinuation of biological disease-modifying antirheumatic drugs (bDMARDs) in some patients with rheumatoid arthritis (RA) (bDMARD-free remission (BFR)). It is unknown which bDMARD is advantageous for achieving BFR or under which conditions BFR can be conside...

journal_title：Arthritis research & therapy

authors： Hashimoto M,Furu M,Yamamoto W,Fujimura T,Hara R,Katayama M,Ohnishi A,Akashi K,Yoshida S,Nagai K,Son Y,Amuro H,Hirano T,Ebina K,Uozumi R,Ito H,Tanaka M,Ohmura K,Fujii T,Mimori T

更新日期：2018-08-03 00:00:00

abstract：:Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7alpha-hydroxy-dehydroepiandrosterone (7alpha-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone, can block glucocorticoid-induced immune suppression. Formation of 7alpha-OH-DHEA is catalyzed by act...

journal_title：Arthritis research & therapy

authors： Dulos J,Kaptein A,Kavelaars A,Heijnen C,Boots A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expres...

journal_title：Arthritis research & therapy

authors： Alivernini S,Bruno D,Tolusso B,Bui L,Petricca L,Gigante MR,Birra D,Fedele AL,Peluso G,Federico F,Ferraccioli G,Gremese E

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS:Fine n...

journal_title：Arthritis research & therapy

authors： Wang DM,Lin L,Peng JH,Gong Y,Hou ZD,Chen SB,Xiao ZY

更新日期：2018-06-08 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have be...

journal_title：Arthritis research & therapy

authors： Roubille C,Raynauld JP,Abram F,Paiement P,Dorais M,Delorme P,Bessette L,Beaulieu AD,Martel-Pelletier J,Pelletier JP

更新日期：2014-12-14 00:00:00

abstract：INTRODUCTION:We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement. METHOD:We searched for available observational studies up to January 2015 in Medline and Embase accordin...

journal_title：Arthritis research & therapy

authors： Bastick AN,Runhaar J,Belo JN,Bierma-Zeinstra SM

更新日期：2015-06-08 00:00:00

abstract：:I comment on the well-designed trial by Alda and colleagues reported in a recent issue of Arthritis Research and Therapy which demonstrated some benefits of cognitive-behavioral therapy (CBT) for fibromyalgia (FM). CBT in this and other studies provides statistically significant but rather modest benefits for FM. This...

journal_title：Arthritis research & therapy

authors： Lumley MA

更新日期：2011-01-01 00:00:00

abstract：:There has been some evidence that Behçet's disease (BD) has a significant autoimmune component but the molecular identity of putative autoantigens has not been well characterized. In the initial analysis of the autoantibody profile in 39 Chinese BD patients, autoantibodies to cellular proteins were uncovered in 23% as...

journal_title：Arthritis research & therapy

authors： Lu Y,Ye P,Chen SL,Tan EM,Chan EK

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The longitudinal degradation mechanism of extracellular matrix (ECM) in the interbertebral disc remains unclear. Our objective was to elucidate catabolic and anabolic gene expression profiles and their balances in intervertebral disc degeneration using a static compression model. METHODS:Forty-eight 12-we...

journal_title：Arthritis research & therapy

authors： Yurube T,Takada T,Suzuki T,Kakutani K,Maeno K,Doita M,Kurosaka M,Nishida K

更新日期：2012-03-06 00:00:00

abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

journal_title：Arthritis research & therapy

authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

journal_title：Arthritis research & therapy

authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

更新日期：2014-07-10 00:00:00

abstract：INTRODUCTION:Bone morphogenetic proteins (BMPs) are critical growth factors in the osteogenic differentiation of progenitor cells during development in embryos and fracture repair in adults. Although recombinant BMPs are in use clinically, their clinical efficiency needs to be improved. The biological activities of BMP...

journal_title：Arthritis research & therapy

authors： Kwong FN,Richardson SM,Evans CH

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Little is known about systemic B-cell activation in early rheumatoid arthritis (RA). We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis cohort. METHODS:In the ESPOIR early arthritis cohort (at least 2 swollen joints for more than 6 we...

journal_title：Arthritis research & therapy

authors： Gottenberg JE,Miceli-Richard C,Ducot B,Goupille P,Combe B,Mariette X

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has not been examined in detail. The purposes of this study were to ex...

journal_title：Arthritis research & therapy

authors： Takegami N,Akeda K,Yamada J,Sano T,Murata K,Huang J,Masuda K,Sudo A

更新日期：2017-06-02 00:00:00

abstract：:Inhibition of NF-kappaB is known to be effective in reducing both inflammation and bone destruction in animal models of arthritis. Our previous study demonstrated that a small cell-permeable NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses expression of proinflammatory cytokines and ameliorates ...

journal_title：Arthritis research & therapy

authors： Kubota T,Hoshino M,Aoki K,Ohya K,Komano Y,Nanki T,Miyasaka N,Umezawa K

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and d...

journal_title：Arthritis research & therapy

authors： Eggleton P,Bremer E,Tarr JM,de Bruyn M,Helfrich W,Kendall A,Haigh RC,Viner NJ,Winyard PG

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of the present study was to evaluate the relationship between baseline CXCL4 level and extent of ILD i...

journal_title：Arthritis research & therapy

authors： Volkmann ER,Tashkin DP,Roth MD,Clements PJ,Khanna D,Furst DE,Mayes M,Charles J,Tseng CH,Elashoff RM,Assassi S

更新日期：2016-12-30 00:00:00

abstract：INTRODUCTION:Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated in representing a novel therapy for rheumatoid arthritis. However, evidence of anti-inflammatory effects of VNS in humans is very scarc...

journal_title：Arthritis research & therapy

authors： Kox M,van Eijk LT,Verhaak T,Frenzel T,Kiers HD,Gerretsen J,van der Hoeven JG,Kornet L,Scheiner A,Pickkers P

更新日期：2015-06-07 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent self-limiting fever and serositis that mainly affects Mediterranean populations. Many patients with FMF have been reported in Japan due to increasing recognition of this condition and the availability of ...

journal_title：Arthritis research & therapy

authors： Kishida D,Nakamura A,Yazaki M,Tsuchiya-Suzuki A,Matsuda M,Ikeda S

更新日期：2014-09-27 00:00:00

abstract：:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction distur...

journal_title：Arthritis research & therapy

authors： Fritsch C,Hoebeke J,Dali H,Ricchiuti V,Isenberg DA,Meyer O,Muller S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The translational and predictive value of animal models highly depends on the validity of respective readout parameters. In arthritis research, there has been a shift from sole threshold testing for pain-related behavior, as well as from swelling and histology assessment for inflammation, toward an analysi...

journal_title：Arthritis research & therapy

authors： Boettger MK,Leuchtweis J,Schaible HG,Schmidt M

更新日期：2011-05-27 00:00:00

abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

journal_title：Arthritis research & therapy

authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

更新日期：2004-01-01 00:00:00

abstract：:The initiation of an immune response requires that professional antigen-presenting cells, such as dendritic cells, physically interact with antigen-specific T cells within the complex environment of the lymph node. Although the way in which antigen is presented to T cells and in particular the cellular associations in...

journal_title：Arthritis research & therapy

authors： Scheinecker C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes. METHODS:We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in algin...

journal_title：Arthritis research & therapy

authors： Husa M,Petursson F,Lotz M,Terkeltaub R,Liu-Bryan R

更新日期：2013-01-01 00:00:00

abstract：:There has been a therapeutic revolution in rheumatology over the past 15 years, characterised by a move away from oral immuno-suppressive drugs toward parenteral targeted biological therapies. The potency and relative safety of the newer agents has facilitated a more aggressive approach to treatment, with many more pa...

journal_title：Arthritis research & therapy

authors： Isaacs JD

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function and angiogenesis. METHODS:Human dermal microvascular endothelial cells (HMVECs) were stimulated wit...

journal_title：Arthritis research & therapy

authors： Shu Q,Amin MA,Ruth JH,Campbell PL,Koch AE

更新日期：2012-04-25 00:00:00