Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial.

abstract：:T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate effector cells involved in the destruction of cartilage and bone, and by contributing to osteoclast differentiation. There are murine models of arthritis, most notably collagen-...

journal_title：Arthritis research & therapy

authors： Kamradt T,Frey O

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypo...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Ruyssen-Witrand A,Huizinga TW,Cantagrel A,Berenbaum F,van der Helm-van Mil AH

更新日期：2015-09-08 00:00:00

abstract：:B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex formation and complement activation in the joints. B cells are also very efficient antigen-presenting cells, ...

journal_title：Arthritis research & therapy

authors： Silverman GJ,Carson DA

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with partic...

journal_title：Arthritis research & therapy

authors： Zhang Z,Ding Y,Li W,Song B,Yang R

更新日期：2013-10-29 00:00:00

abstract：INTRODUCTION:Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate wh...

journal_title：Arthritis research & therapy

authors： Lee SY,Kwok SK,Son HJ,Ryu JG,Kim EK,Oh HJ,Cho ML,Ju JH,Park SH,Kim HY

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：INTRODUCTION:Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is available for...

journal_title：Arthritis research & therapy

authors： Mahmood Z,Muhammad K,Schmalzing M,Roll P,Dörner T,Tony HP

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

journal_title：Arthritis research & therapy

authors： Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

更新日期：2020-04-15 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the disease contributing to joint damage is synovial hyperplasia. The factors responsible for the hyperplasia are u...

journal_title：Arthritis research & therapy

authors： Tu-Rapp H,Hammermüller A,Mix E,Kreutzer HJ,Goerlich R,Köhler H,Nizze H,Thiesen HJ,Ibrahim SM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destruction. The objective of this study was to decipher the link between autophagy and regulatory mechanism o...

journal_title：Arthritis research & therapy

authors： Wang F,Liu J,Chen X,Zheng X,Qu N,Zhang B,Xia C

更新日期：2019-07-10 00:00:00

abstract：:Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell ...

journal_title：Arthritis research & therapy

authors： Gillespie MT

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of A...

journal_title：Arthritis research & therapy

authors： Moxey J,Huq M,Proudman S,Sahhar J,Ngian GS,Walker J,Strickland G,Wilson M,Ross L,Major G,Roddy J,Stevens W,Nikpour M

更新日期：2019-02-14 00:00:00

abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

journal_title：Arthritis research & therapy

authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

更新日期：2004-01-01 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：BACKGROUND:The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has been demonstrated to be effective. However, there is still room for improvement. Therefore, we aimed t...

journal_title：Arthritis research & therapy

authors： Regueiro C,Rodríguez-Martínez L,Nuño L,Ortiz AM,Villalba A,Pascual-Salcedo D,Martínez-Feito A,González-Alvaro I,Balsa A,Gonzalez A

更新日期：2019-12-11 00:00:00

abstract：BACKGROUND:In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to ...

journal_title：Arthritis research & therapy

authors： Esposito J,Brown Z,Stevens W,Sahhar J,Rabusa C,Zochling J,Roddy J,Walker J,Proudman SM,Nikpour M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

journal_title：Arthritis research & therapy

authors： Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

更新日期：2020-12-10 00:00:00

abstract：BACKGROUND:Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawal of the bDMARD. Results from published studies indicate that some patients will maintain remission;...

journal_title：Arthritis research & therapy

authors： Tanaka Y,Smolen JS,Jones H,Szumski A,Marshall L,Emery P

更新日期：2019-07-05 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：:The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta₂ glycoprotein I (anti-β₂GPI) and lupus anticoagulant (LA) assays are not only ...

journal_title：Arthritis research & therapy

authors： Meroni PL,Chighizola CB,Rovelli F,Gerosa M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA). METHODS:Arthritis was induced by intraperitoneal injection of a collagen antibody cocktail into properdin-deficient (KO) and w...

journal_title：Arthritis research & therapy

authors： Dimitrova P,Ivanovska N,Belenska L,Milanova V,Schwaeble W,Stover C

更新日期：2012-07-25 00:00:00

abstract：OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who ...

journal_title：Arthritis research & therapy

authors： Chen J,Luo Y,Zhao M,Wu D,Yang Y,Zhang W,Shen M

更新日期：2019-11-12 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc). Screening guidelines for PAH recommend multiple investigations, including annual echocardiography, which together have low specificity and may not be cost-effective. We sought to evaluate the predictive accurac...

journal_title：Arthritis research & therapy

authors： Thakkar V,Stevens W,Prior D,Youssef P,Liew D,Gabbay E,Roddy J,Walker JG,Zochling J,Sahhar J,Nash P,Lester S,Rischmueller M,Proudman SM,Nikpour M

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

journal_title：Arthritis research & therapy

authors： Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

更新日期：2014-10-30 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin (a well recognized BMP inhibitor) and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell...

journal_title：Arthritis research & therapy

authors： Heliotis M,Tsiridis E

更新日期：2008-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full publications and abstracts of randomised trials and cohort studies by using a variety of search strategies. Effi...

journal_title：Arthritis research & therapy

authors： Moore RA,Derry S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease ...

journal_title：Arthritis research & therapy

authors： Rastogi A,Kim H,Twomey JD,Hsieh AH

更新日期：2013-04-27 00:00:00