当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > A proinflammatory role for Fas in joints of mice with collagen-induced arthritis.

A proinflammatory role for Fas in joints of mice with collagen-induced arthritis.

Abstract：

:Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the disease contributing to joint damage is synovial hyperplasia. The factors responsible for the hyperplasia are unknown; however, an imbalance between rates of cell proliferation and cell death (apoptosis) has been suggested. To evaluate the role of a major pathway of cell death - Fas (CD95)/FasL - in the pathogenesis of CIA, DBA/1J mice with a mutation of the Fas gene (lpr) were generated. The susceptibility of the mutant DBA-lpr/lpr mice to arthritis induced by collagen type II was evaluated. Contrary to expectations, the DBA-lpr/lpr mice developed significantly milder disease than the control littermates. The incidence of disease was also significantly lower in the lpr/lpr mice than in the controls (40% versus 81%; P < 0.05). However DBA-lpr/lpr mice mounted a robust immune response to collagen, and the expression of local proinflammatory cytokines such as, e.g., tumor necrosis factor alpha (TNF-alpha) and IL-6 were increased at the onset of disease. Since the contribution of synovial fibroblasts to inflammation and joint destruction is crucial, the potential activating effect of Fas on mouse fibroblast cell line NIH3T3 was investigated. On treatment with anti-Fas in vitro, the cell death of NIH3T3 fibroblasts was reduced and the expression of proinflammatory cytokines TNF-alpha and IL-6 was increased. These findings suggest that impairment of immune tolerance by increased T-cell reactivity does not lead to enhanced susceptibility to CIA and point to a role of Fas in joint destruction.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Tu-Rapp H,Hammermüller A,Mix E,Kreutzer HJ,Goerlich R,Köhler H,Nizze H,Thiesen HJ,Ibrahim SM

doi

10.1186/ar1205

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

R404-14

issue

5

eissn

1478-6354

issn

1478-6362

pii

ar1205

journal_volume

6

pub_type

杂志文章

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Arthritis: where are the T cells?

    abstract：:T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate effector cells involved in the destruction of cartilage and bone, and by contributing to osteoclast differentiation. There are murine models of arthritis, most notably collagen-...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3008

    authors： Kamradt T,Frey O

    更新日期：2010-01-01 00:00:00

  • Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells.

    abstract：:Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar4230

    authors： Gilbane AJ,Denton CP,Holmes AM

    更新日期：2013-01-01 00:00:00

  • Insensitivity versus poor response to tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective cohort study.

    abstract：BACKGROUND:With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-2122-5

    authors： Ochi S,Saito K,Mizoguchi F,Kato S,Tanaka Y

    更新日期：2020-03-04 00:00:00

  • Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.

    abstract：:The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased synovial vascularity, and henc...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2340

    authors： Bainbridge J,Madden L,Essex D,Binks M,Malhotra R,Paleolog EM

    更新日期：2007-01-01 00:00:00

  • Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition.

    abstract：INTRODUCTION:Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function. METHODS:Caspase-1 expression in rheumatoid arthritis (RA) synovial fibroblasts treated with TNF was assessed by...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4551

    authors： Marotte H,Tsou PS,Fedorova T,Pinney AJ,Lewis B,Koch AE

    更新日期：2014-04-24 00:00:00

  • The epidemiology of symptomatic midfoot osteoarthritis in community-dwelling older adults: cross-sectional findings from the Clinical Assessment Study of the Foot.

    abstract：INTRODUCTION:The foot is largely overlooked in calls for better characterisation of clinical phenotypes in osteoarthritis (OA). Yet the midfoot complex in particular has the potential to provide important insights into OA pathogenesis given its central role in lower limb load transmission and alignment. Its recent incl...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0693-3

    authors： Thomas MJ,Peat G,Rathod T,Marshall M,Moore A,Menz HB,Roddy E

    更新日期：2015-07-13 00:00:00

  • Mechanisms of B cell autoimmunity in SLE.

    abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyper-reactivity leading to polyclonal B-cell activation wit...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3433

    authors： Dörner T,Giesecke C,Lipsky PE

    更新日期：2011-01-01 00:00:00

  • Managing pregnancy in inflammatory rheumatological diseases.

    abstract：:Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3227

    authors： Jain V,Gordon C

    更新日期：2011-02-25 00:00:00

  • The role and clinical implications of G6PI in experimental models of rheumatoid arthritis.

    abstract：:The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA) remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently, murine models of arthritis are induced by imm...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1476

    authors： Kamradt T,Schubert D

    更新日期：2005-01-01 00:00:00

  • Association of physical activity and physical performance with tibial cartilage volume and bone area in young adults.

    abstract：INTRODUCTION:Physical activity has been recommended to patients with knee osteoarthritis for improving their symptoms. However, it is still controversial if physical activity has effects on joint structures including cartilage volume. The aim of this study was to describe the associations between physical activity and ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0813-0

    authors： Antony B,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Jones G,Ding C

    更新日期：2015-10-26 00:00:00

  • What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?

    abstract：:This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (molecular target, isotype, registered indication for JIA, route of administration, half-life, contraindication...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar4213

    authors： Swart JF,de Roock S,Wulffraat NM

    更新日期：2013-01-01 00:00:00

  • Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

    abstract：BACKGROUND:The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort. METHODS:All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Sp...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-018-1776-8

    authors： Narváez J,Borrell H,Sánchez-Alonso F,Rúa-Figueroa I,López-Longo FJ,Galindo-Izquierdo M,Calvo-Alén J,Fernández-Nebro A,Olivé A,Andreu JL,Martínez-Taboada V,Nolla JM,Pego-Reigosa JM,RELESSER Study Group.

    更新日期：2018-12-19 00:00:00

  • Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.

    abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3843

    authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

    更新日期：2012-06-08 00:00:00

  • Elucidation of the potential roles of matrix metalloproteinases in skeletal biology.

    abstract：:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar600

    authors： Krane SM

    更新日期：2003-01-01 00:00:00

  • Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.

    abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1220-5

    authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

    更新日期：2017-02-02 00:00:00

  • Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment.

    abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2992

    authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

    更新日期：2010-01-01 00:00:00

  • Secukinumab provides rapid and sustained pain relief in psoriatic arthritis over 2 years: results from the FUTURE 2 study.

    abstract：BACKGROUND:Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and symptoms, including HRQoL, among patients with active PsA. This analysis evaluates the effect of se...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s13075-018-1610-3

    authors： McInnes IB,Mease PJ,Schett G,Kirkham B,Strand V,Williams N,Fox T,Pricop L,Jugl SM,Gandhi KK,FUTURE 2 Study Group.

    更新日期：2018-06-07 00:00:00

  • Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.

    abstract：BACKGROUND:Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patien...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-018-1578-z

    authors： Cole S,Walsh A,Yin X,Wechalekar MD,Smith MD,Proudman SM,Veale DJ,Fearon U,Pitzalis C,Humby F,Bombardieri M,Axel A,Adams H 3rd,Chiu C,Sharp M,Alvarez J,Anderson I,Madakamutil L,Nagpal S,Guo Y

    更新日期：2018-05-02 00:00:00

  • CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis.

    abstract：INTRODUCTION:CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, we examined whether C/EBPβ mediates the expression of receptor activator of nuclear factor-kappa-B ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0532-6

    authors： Tsushima H,Okazaki K,Ishihara K,Ushijima T,Iwamoto Y

    更新日期：2015-02-17 00:00:00

  • Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.

    abstract：INTRODUCTION:Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic differences are particularly at...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3911

    authors： Wiese MD,Schnabl M,O'Doherty C,Spargo LD,Sorich MJ,Cleland LG,Proudman SM

    更新日期：2012-07-12 00:00:00

  • The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study.

    abstract：INTRODUCTION:We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We recently found that another RANKL binding peptide, W9, could accelerate bone formation by affecting ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0753-8

    authors： Kato G,Shimizu Y,Arai Y,Suzuki N,Sugamori Y,Maeda M,Takahashi M,Tamura Y,Wakabayashi N,Murali R,Ono T,Ohya K,Mise-Omata S,Aoki K

    更新日期：2015-09-12 00:00:00

  • Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis.

    abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-0984-3

    authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

    更新日期：2016-04-12 00:00:00

  • The increased cardiovascular risk in rheumatoid arthritis: when does it start?

    abstract：:Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular e...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3126

    authors： Nurmohamed MT

    更新日期：2010-01-01 00:00:00

  • Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis.

    abstract：INTRODUCTION:Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microar...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0873-1

    authors： Nigil Haroon N,Szabo E,Raboud JM,Mcdonald-Blumer H,Fung L,Josse RG,Inman RD,Cheung AM

    更新日期：2015-12-24 00:00:00

  • Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.

    abstract：INTRODUCTION:The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3750

    authors： Lee SI,Boyle DL,Berdeja A,Firestein GS

    更新日期：2012-02-21 00:00:00

  • Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

    abstract：INTRODUCTION:Progressive fibrosis in systemic sclerosis (SSc) is linked to aberrant transforming growth factor beta (TGF-beta) signaling. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) blocks fibrogenic TGF-beta responses in vitro and in vivo. Reduced expression and function of PPAR-gamma in patients wit...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3827

    authors： Lakota K,Wei J,Carns M,Hinchcliff M,Lee J,Whitfield ML,Sodin-Semrl S,Varga J

    更新日期：2012-05-01 00:00:00

  • Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study.

    abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0756-5

    authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

    更新日期：2015-08-28 00:00:00

  • Population-wide incidence estimates for soft tissue knee injuries presenting to healthcare in southern Sweden: data from the Skåne Healthcare Register.

    abstract：INTRODUCTION:Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue kne...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4678

    authors： Peat G,Bergknut C,Frobell R,Jöud A,Englund M

    更新日期：2014-07-31 00:00:00

  • 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block.

    abstract：:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction distur...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1848

    authors： Fritsch C,Hoebeke J,Dali H,Ricchiuti V,Isenberg DA,Meyer O,Muller S

    更新日期：2006-01-01 00:00:00

  • Rheumatoid arthritis patients are not at increased risk for 30-day cardiovascular events, infections, or mortality after total joint arthroplasty.

    abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4385

    authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

    更新日期：2013-01-01 00:00:00