Population-wide incidence estimates for soft tissue knee injuries presenting to healthcare in southern Sweden: data from the Skåne Healthcare Register.

Abstract:

INTRODUCTION:Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue knee injuries, and their distribution by age, sex, and season. METHODS:In Sweden, in- and outpatient health care is registered using each individuals' unique personal identifier including International Classification of Diseases (ICD) 10 diagnostic code(s) as determined by physicians' clinical examination. For the calendar years 2004-2012, we studied the population in southern Sweden, Skåne region (approx. 1.3 million). We identified residents who had at least one visit to a physician with clinically diagnosed knee ligament, meniscal, or other soft-tissue injury (S80.0, S83 and all subdiagnoses). We then calculated the mean annual incidence over the 9-year period. As a secondary objective, we investigated potential seasonal variation. RESULTS:The annual incidence for males and females was 766 (95% CI: 742, 789) and 676 (649, 702) per 100,000 persons/year respectively. For males and females, the peak rate occurred in 15 to 19 year-olds (1698 per 100,000 men and 1464 per 100,000 women, respectively). In women, rates were lowest in the 25 to 34 year-old age range before rising again between the ages of 35 and 49 years. We found substantial seasonal variation, greatest in men, with peaks in March-May and August-October. CONCLUSIONS:The incidence of clinically diagnosed soft-tissue knee injury peaks in adolescence and emerging adulthood. However, a range of knee injuries continue to occur across the adult lifespan including at ages when osteoarthritis is typically diagnosed and managed. The potential cumulative effect on osteoarthritis progression of these injuries may warrant further investigation.

journal_name

Arthritis Res Ther

authors

Peat G,Bergknut C,Frobell R,Jöud A,Englund M

doi

10.1186/ar4678

subject

Has Abstract

pub_date

2014-07-31 00:00:00

pages

R162

issue

4

eissn

1478-6354

issn

1478-6362

pii

ar4678

journal_volume

16

pub_type

杂志文章
  • B cells in rheumatoid synovitis.

    abstract::In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B c...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar1737

    authors: Weyand CM,Seyler TM,Goronzy JJ

    更新日期:2005-01-01 00:00:00

  • A rheumatoid factor paradox: inhibition of rituximab effector function.

    abstract:INTRODUCTION:Rituximab (RTX) therapy of rheumatoid arthritis (RA) exhibits enhanced effectiveness in seropositive patients. Using patient sera, we tested if this improved efficacy was associated with enhanced RTX mediated complement-dependent cytotoxicity (RTX-CDC). METHODS:We developed an in vitro assay for RTX-CDC u...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4152

    authors: Jones JD,Shyu I,Newkirk MM,Rigby WF

    更新日期:2013-01-25 00:00:00

  • Very different performance of the power Doppler modalities of several ultrasound machines ascertained by a microvessel flow phantom.

    abstract:INTRODUCTION:In many patients with rheumatoid arthritis (RA) subclinical disease activity can be detected with ultrasound (US), especially using power Doppler US (PDUS). However, PDUS may be highly dependent on the type of machine. This could create problems both in clinical trials and in daily clinical practice. To cl...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4345

    authors: Ten Cate DF,Luime JJ,van der Ven M,Hazes JM,Kooiman K,de Jong N,Bosch JG

    更新日期:2013-10-24 00:00:00

  • Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis.

    abstract:INTRODUCTION:Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA). METHODS:Arthritis was induced by intraperitoneal injection of a collagen antibody cocktail into properdin-deficient (KO) and w...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3926

    authors: Dimitrova P,Ivanovska N,Belenska L,Milanova V,Schwaeble W,Stover C

    更新日期:2012-07-25 00:00:00

  • Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis.

    abstract:BACKGROUND:The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS:Fine n...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-018-1594-z

    authors: Wang DM,Lin L,Peng JH,Gong Y,Hou ZD,Chen SB,Xiao ZY

    更新日期:2018-06-08 00:00:00

  • Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?

    abstract:INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3505

    authors: De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

    更新日期:2011-01-01 00:00:00

  • Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitinib.

    abstract:BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02324-7

    authors: Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

    更新日期:2020-10-15 00:00:00

  • Managing pregnancy in inflammatory rheumatological diseases.

    abstract::Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsi...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3227

    authors: Jain V,Gordon C

    更新日期:2011-02-25 00:00:00

  • Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases.

    abstract:INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3330

    authors: O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

    更新日期:2011-04-26 00:00:00

  • Quantitative biomarker analysis of synovial gene expression by real-time PCR.

    abstract::Synovial biomarker analysis in rheumatoid arthritis can be used to evaluate drug effect in clinical trials of novel therapeutic agents. Previous studies of synovial gene expression for these studies have mainly relied on histological methods including immunohistochemistry and in situ hybridization. To increase the rel...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar1004

    authors: Boyle DL,Rosengren S,Bugbee W,Kavanaugh A,Firestein GS

    更新日期:2003-01-01 00:00:00

  • Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study).

    abstract:INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s13075-014-0467-3

    authors: Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

    更新日期:2014-10-30 00:00:00

  • Scleroderma-polymyositis overlap syndrome versus idiopathic polymyositis and systemic sclerosis: a descriptive study on clinical features and myopathology.

    abstract:INTRODUCTION:The objective was to characterize the clinical and myopathologic features of patients with scleroderma-polymyositis (SSc-PM) overlap compared with a population of patients with systemic sclerosis (SSc) and polymyositis (PM). METHODS:A three-way comparison of patients with SSc-PM overlap (n = 25) with pati...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4562

    authors: Bhansing KJ,Lammens M,Knaapen HK,van Riel PL,van Engelen BG,Vonk MC

    更新日期:2014-05-13 00:00:00

  • Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature.

    abstract:INTRODUCTION:Mutations in the NLRP3 gene are associated with the dominantly inherited cryopyrin-associated periodic syndrome (CAPS). The significance of the V198M variant is unclear; it has been reported in association with various CAPS phenotypes and as a variant of uncertain consequence. The aim of this study was to ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4171

    authors: Rowczenio DM,Trojer H,Russell T,Baginska A,Lane T,Stewart NM,Gillmore JD,Hawkins PN,Woo P,Mikoluc B,Lachmann HJ

    更新日期:2013-02-19 00:00:00

  • Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials.

    abstract:INTRODUCTION:The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS. METHODS:The Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDISCUS (through April 2009) and the re...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/ar3002

    authors: Häuser W,Klose P,Langhorst J,Moradi B,Steinbach M,Schiltenwolf M,Busch A

    更新日期:2010-01-01 00:00:00

  • DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system.

    abstract:BACKGROUND:Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of RA are largely unknown. We investigated the role of Dickkopf-related protein 1 (DKK1) produced by syn...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-016-0915-3

    authors: Juarez M,McGettrick HM,Scheel-Toellner D,Yeo L,Spengler J,de Paz B,Hardy R,Cooper M,Raza K,Buckley CD,Filer A

    更新日期:2016-01-19 00:00:00

  • Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study.

    abstract:INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0756-5

    authors: Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

    更新日期:2015-08-28 00:00:00

  • Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis.

    abstract:INTRODUCTION:Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4300

    authors: Bagnato G,Bitto A,Irrera N,Pizzino G,Sangari D,Cinquegrani M,Roberts W,Atteritano M,Altavilla D,Squadrito F,Bagnato G,Saitta A

    更新日期:2013-09-16 00:00:00

  • Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment.

    abstract:BACKGROUND:Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF b...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-1846-6

    authors: Estelius J,Lengqvist J,Ossipova E,Idborg H,Le Maître E,Andersson MLA,Brundin L,Khademi M,Svenungsson E,Jakobsson PJ,Lampa J

    更新日期:2019-02-15 00:00:00

  • A Dose-response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine.

    abstract:INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0820-1

    authors: Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

    更新日期:2015-10-23 00:00:00

  • Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion.

    abstract:INTRODUCTION:Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3123

    authors: Dalbeth N,Pool B,Smith T,Callon KE,Lobo M,Taylor WJ,Jones PB,Cornish J,McQueen FM

    更新日期:2010-01-01 00:00:00

  • A novel DNA/histone H4 peptide complex detects autoantibodies in systemic lupus erythematosus sera.

    abstract:BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-016-1117-8

    authors: Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

    更新日期:2016-10-04 00:00:00

  • Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis.

    abstract::Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full publications and abstracts of randomised trials and cohort studies by using a variety of search strategies. Effi...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/ar2093

    authors: Moore RA,Derry S

    更新日期:2006-01-01 00:00:00

  • The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation.

    abstract:INTRODUCTION:The purpose of this study was to evaluate the effects of risedronate (Ris) in the modulation of bone formation in rats with glucocorticoid (GC)-induced osteoporosis by histomorphometric, immunohistochemical and gene expression analyses. METHODS:We analyzed structure, turnover and microarchitecture, cycloo...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3122

    authors: Valenti MT,Giannini S,Donatelli L,Zanatta M,Bertoldo F,Sella S,Vilei MT,Ossi E,Realdi G,Lo Cascio V,Dalle Carbonare L

    更新日期:2010-01-01 00:00:00

  • Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis.

    abstract::In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflamm...

    journal_title:Arthritis research & therapy

    pub_type: 评论,社论

    doi:10.1186/ar3115

    authors: Mendez-Fernandez Y,Major A

    更新日期:2010-01-01 00:00:00

  • Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

    abstract:BACKGROUND:Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02269-x

    authors: Tachibana M,Yonemoto Y,Okamura K,Suto T,Sakane H,Kaneko T,Dam TT,Okura C,Tajika T,Tsushima Y,Chikuda H

    更新日期:2020-07-25 00:00:00

  • Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor/anti-citrulline antibody-negative rheumatoid arthritis.

    abstract:BACKGROUND:Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expres...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-1898-7

    authors: Alivernini S,Bruno D,Tolusso B,Bui L,Petricca L,Gigante MR,Birra D,Fedele AL,Peluso G,Federico F,Ferraccioli G,Gremese E

    更新日期:2019-05-09 00:00:00

  • Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial.

    abstract:INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/ar3554

    authors: Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

    更新日期:2012-01-08 00:00:00

  • Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides.

    abstract::Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it provides the diagnostic procedures required to asses a patient with vascul...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3307

    authors: Holle JU,Moosig F,Dalhoff K,Gross WL

    更新日期:2011-06-30 00:00:00

  • Triamcinolone acetonide activates an anti-inflammatory and folate receptor-positive macrophage that prevents osteophytosis in vivo.

    abstract:INTRODUCTION:Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by synovial macrophage activation. TA injections might influence macrophage activation and subsequently...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0865-1

    authors: Siebelt M,Korthagen N,Wei W,Groen H,Bastiaansen-Jenniskens Y,Müller C,Waarsing JH,de Jong M,Weinans H

    更新日期:2015-12-05 00:00:00

  • Mechanisms of B cell autoimmunity in SLE.

    abstract::Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyper-reactivity leading to polyclonal B-cell activation wit...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3433

    authors: Dörner T,Giesecke C,Lipsky PE

    更新日期:2011-01-01 00:00:00