Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides.

abstract：INTRODUCTION:Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by synovial macrophage activation. TA injections might influence macrophage activation and subsequently...

journal_title：Arthritis research & therapy

authors： Siebelt M,Korthagen N,Wei W,Groen H,Bastiaansen-Jenniskens Y,Müller C,Waarsing JH,de Jong M,Weinans H

更新日期：2015-12-05 00:00:00

abstract：:Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular e...

journal_title：Arthritis research & therapy

authors： Nurmohamed MT

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced arthritis. This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific ...

journal_title：Arthritis research & therapy

authors： Vadasz Z,Haj T,Halasz K,Rosner I,Slobodin G,Attias D,Kessel A,Kessler O,Neufeld G,Toubi E

更新日期：2012-06-14 00:00:00

abstract：INTRODUCTION:Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects. METHODS:Human Col I...

journal_title：Arthritis research & therapy

authors： El-Bikai R,Welman M,Margaron Y,Côté JF,Macqueen L,Buschmann MD,Fahmi H,Shi Q,Maghni K,Fernandes JC,Benderdour M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to ...

journal_title：Arthritis research & therapy

authors： Hughes C,Sette A,Seed M,D'Acquisto F,Manzo A,Vincent TL,Lim NH,Nissim A

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

journal_title：Arthritis research & therapy

authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

更新日期：2020-07-16 00:00:00

abstract：:Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus an...

journal_title：Arthritis research & therapy

authors： Gray SG

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations in the T lymphocyte compartment and dysregulated cytokine production are key features of SLE pathogenesis and disease progression. Recently...

journal_title：Arthritis research & therapy

authors： Puwipirom H,Hirankarn N,Sodsai P,Avihingsanon Y,Wongpiyabovorn J,Palaga T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype of RA-FLS and attenua...

journal_title：Arthritis research & therapy

authors： Pethő Z,Tanner MR,Tajhya RB,Huq R,Laragione T,Panyi G,Gulko PS,Beeton C

更新日期：2016-05-10 00:00:00

abstract：INTRODUCTION:Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that...

journal_title：Arthritis research & therapy

authors： Klingberg E,Lorentzon M,Göthlin J,Mellström D,Geijer M,Ohlsson C,Atkinson EJ,Khosla S,Carlsten H,Forsblad-d'Elia H

更新日期：2013-01-01 00:00:00

abstract：:The characteristic of a biomarker that makes it a useful surrogate is the ability to identify a high risk of clinically important benefits or harms occurring in the future. A number of definitions or descriptions of surrogate definition have been put forward. Most recently the Institute of Medicine of the National Aca...

journal_title：Arthritis research & therapy

authors： Andrew Moore R

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

journal_title：Arthritis research & therapy

authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS:Fine n...

journal_title：Arthritis research & therapy

authors： Wang DM,Lin L,Peng JH,Gong Y,Hou ZD,Chen SB,Xiao ZY

更新日期：2018-06-08 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：:Human T cell leukaemia virus type I (HTLV-I) is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However, it is unclear whether HTLV-I infection could modify the pathophysiology of osteoarthritis (OA). In this study we compared several inflammatory cytokines, such as C-termina...

journal_title：Arthritis research & therapy

authors： Yoshihara Y,Tsukazaki T,Osaki M,Nakashima M,Hasui K,Shindo H

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Cardiovascular disease (CVD) is the leading cause of death in patients with inflammatory polyarthritis (IP), especially in seropositive disease. In established rheumatoid arthritis (RA), insulin resistance (IR) is increased and associated with CVD. We investigated factors associated with IR in an inception...

journal_title：Arthritis research & therapy

authors： Mirjafari H,Farragher TM,Verstappen SM,Yates A,Bunn D,Marshall T,Lunt M,Symmons DP,Bruce IN

更新日期：2011-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor erythroid 2-related factor 2 (Nrf2) as a major requirement for limiting cartilage destruction. NF-...

journal_title：Arthritis research & therapy

authors： Fragoulis A,Laufs J,Müller S,Soppa U,Siegl S,Reiss LK,Tohidnezhad M,Rosen C,Tenbrock K,Varoga D,Lippross S,Pufe T,Wruck CJ

更新日期：2012-10-27 00:00:00

abstract：BACKGROUND:The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destruction, an...

journal_title：Arthritis research & therapy

authors： Atkinson SM,Bleil J,Maier R,Kühl AA,Thorn M,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A,Syrbe U

更新日期：2016-01-23 00:00:00

abstract：BACKGROUND:The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has been demonstrated to be effective. However, there is still room for improvement. Therefore, we aimed t...

journal_title：Arthritis research & therapy

authors： Regueiro C,Rodríguez-Martínez L,Nuño L,Ortiz AM,Villalba A,Pascual-Salcedo D,Martínez-Feito A,González-Alvaro I,Balsa A,Gonzalez A

更新日期：2019-12-11 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

journal_title：Arthritis research & therapy

authors： Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previously reported that tofacitinib, a JAK inhibitor, facilitates the expansion of myeloid-derived suppres...

journal_title：Arthritis research & therapy

authors： Sendo S,Saegusa J,Yamada H,Nishimura K,Morinobu A

更新日期：2019-08-06 00:00:00

abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

journal_title：Arthritis research & therapy

authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

更新日期：2014-07-10 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

journal_title：Arthritis research & therapy

authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase ...

journal_title：Arthritis research & therapy

authors： Lee SI,Boyle DL,Berdeja A,Firestein GS

更新日期：2012-02-21 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might...

journal_title：Arthritis research & therapy

authors： Berthelot JM,Le Goff B,Maugars Y

更新日期：2019-11-13 00:00:00

abstract：:In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by the associated high rates of psychological distress and somatisation. We address the hypothesis that the latte...

journal_title：Arthritis research & therapy

authors： McBeth J,Chiu YH,Silman AJ,Ray D,Morriss R,Dickens C,Gupta A,Macfarlane GJ

更新日期：2005-01-01 00:00:00