Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis.

abstract：INTRODUCTION:Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microar...

journal_title：Arthritis research & therapy

authors： Nigil Haroon N,Szabo E,Raboud JM,Mcdonald-Blumer H,Fung L,Josse RG,Inman RD,Cheung AM

更新日期：2015-12-24 00:00:00

abstract：BACKGROUND:In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and conflicting. Results similarly conflict regarding its usage in patients with nonspecific chronic low back ...

journal_title：Arthritis research & therapy

authors： Huang Z,Ma J,Chen J,Shen B,Pei F,Kraus VB

更新日期：2015-12-15 00:00:00

abstract：:A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors can be recruited into autoimmune responses underpin this paradigm. The implications of these observ...

journal_title：Arthritis research & therapy

authors： Lafyatis R,Marshak-Rothstein A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE:To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active ...

journal_title：Arthritis research & therapy

authors： Glimm AM,Sprenger LI,Haugen IK,Mansmann U,Hermann S,Häupl T,Hoff P,Burmester GR,Backhaus M,Le L,Ohrndorf S

更新日期：2019-09-18 00:00:00

abstract：:The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been m...

journal_title：Arthritis research & therapy

authors： Lachmann HJ,Hawkins PN

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have be...

journal_title：Arthritis research & therapy

authors： Roubille C,Raynauld JP,Abram F,Paiement P,Dorais M,Delorme P,Bessette L,Beaulieu AD,Martel-Pelletier J,Pelletier JP

更新日期：2014-12-14 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyper-reactivity leading to polyclonal B-cell activation wit...

journal_title：Arthritis research & therapy

authors： Dörner T,Giesecke C,Lipsky PE

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has been well de...

journal_title：Arthritis research & therapy

authors： Mattyasovszky SG,Hofmann A,Brochhausen C,Ritz U,Kuhn S,Wollstädter J,Schulze-Koops H,Müller LP,Watzer B,Rommens PM

更新日期：2010-01-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has not been examined in detail. The purposes of this study were to ex...

journal_title：Arthritis research & therapy

authors： Takegami N,Akeda K,Yamada J,Sano T,Murata K,Huang J,Masuda K,Sudo A

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a plays a central role. In this study, plasma and urinary levels of C5a as well as renal C5a receptors (CD88 and C5L2) expression were investigated in patients wi...

journal_title：Arthritis research & therapy

authors： Yuan J,Gou SJ,Huang J,Hao J,Chen M,Zhao MH

更新日期：2012-06-12 00:00:00

abstract：INTRODUCTION:Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease ...

journal_title：Arthritis research & therapy

authors： Rastogi A,Kim H,Twomey JD,Hsieh AH

更新日期：2013-04-27 00:00:00

abstract：:The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

journal_title：Arthritis research & therapy

authors： Fritzler MJ,Wiik A,Fritzler ML,Barr SG

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：BACKGROUND:The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS:Fine n...

journal_title：Arthritis research & therapy

authors： Wang DM,Lin L,Peng JH,Gong Y,Hou ZD,Chen SB,Xiao ZY

更新日期：2018-06-08 00:00:00

abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

journal_title：Arthritis research & therapy

authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

更新日期：2016-04-12 00:00:00

abstract：:Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect. ...

journal_title：Arthritis research & therapy

authors： Drivelegka P,Sigurdardottir V,Svärd A,Jacobsson LTH,Dehlin M

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：:Pleiotropic effects are now described for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammat...

journal_title：Arthritis research & therapy

authors： McCarey DW,Sattar N,McInnes IB

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these patients, particularly with the widespread use of immunomodulating therapies, including biologic disease-modifying antirheumatic drugs (DMARDs). We...

journal_title：Arthritis research & therapy

authors： Simon TA,Thompson A,Gandhi KK,Hochberg MC,Suissa S

更新日期：2015-08-15 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory find...

journal_title：Arthritis research & therapy

authors： Sugiyama Y,Yoshimi R,Tamura M,Takeno M,Kunishita Y,Kishimoto D,Yoshioka Y,Kobayashi K,Takase-Minegishi K,Watanabe T,Hamada N,Nagai H,Tsuchida N,Soejima Y,Nakano H,Kamiyama R,Uehara T,Kirino Y,Sekiguchi A,Ihata A,O

更新日期：2018-01-11 00:00:00

abstract：INTRODUCTION:Patients with recent-onset rheumatoid arthritis (RA) have impaired brachial artery endothelial function compared with controls matched for age, sex and cardiovascular risk factors. The present study examined endothelium-dependent (flow-mediated dilatation (FMD)) and independent (glyceryl trinitrate (GTN)-m...

journal_title：Arthritis research & therapy

authors： Hannawi S,Marwick TH,Thomas R

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and d...

journal_title：Arthritis research & therapy

authors： Eggleton P,Bremer E,Tarr JM,de Bruyn M,Helfrich W,Kendall A,Haigh RC,Viner NJ,Winyard PG

更新日期：2011-01-01 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：:A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 responses in 54%, 26% and 8% of patients, respectively. A placebo group was not included. Thirty-seven per cent of...

journal_title：Arthritis research & therapy

authors： Walker UA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

journal_title：Arthritis research & therapy

authors： Ota T,Ota SI,Uchino A,Nagano S

更新日期：2020-06-26 00:00:00

abstract：INTRODUCTION:Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS:RA patie...

journal_title：Arthritis research & therapy

authors： Mulleman D,Méric JC,Paintaud G,Ducourau E,Magdelaine-Beuzelin C,Valat JP,Goupille P,Centre National de la Recherche Scientifique UMR 6239 GICC.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived growth factor receptor (PDGFR) activation promote collagen I (Col I) production, leading to fibrosis in SSc. Lipoic acid (LA) and its active metabolite...

journal_title：Arthritis research & therapy

authors： Tsou PS,Balogh B,Pinney AJ,Zakhem G,Lozier A,Amin MA,Stinson WA,Schiopu E,Khanna D,Fox DA,Koch AE

更新日期：2014-01-01 00:00:00