当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

Abstract：

INTRODUCTION:Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and determined if Th17 cells belong to a CD20+ subset of T cells. METHODS:Fluorescence-activated cell sorting and confocal microscopy verified CD3, CD4/CD8 and CD20-staining of T cells. IL-17 secretion was determined using a commercial assay. RESULTS:In healthy subjects and RA patients blood, the median percentage of total CD20+ lymphocytes was similar (7.5%; n = 6 and 10.3%; n = 9, respectively) and comprised predominantly of B cells (~ 86%). However, 2-4% of CD3+ T cells from both healthy subjects (n = 7) and RA (n = 8) individuals co-expressed CD20. The peripheral blood of healthy subjects contained few IL-17-secreting CD20+ T cells (< 0.1%; n = 6). In contrast, in RA blood a median and interquartile range % of, 24.2%; IQR 28.5 of IL-17-secreting T cells were CD20+ (n = 9; p = 0.02). CONCLUSIONS:In the blood of RA patients, a greater proportion of Th17 cells are of a CD20+ phenotype compared to healthy individuals. These cells may represent an additional target for anti-CD20 therapies.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Eggleton P,Bremer E,Tarr JM,de Bruyn M,Helfrich W,Kendall A,Haigh RC,Viner NJ,Winyard PG

doi

10.1186/ar3541

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

R208

issue

6

eissn

1478-6354

issn

1478-6362

pii

ar3541

journal_volume

13

pub_type

杂志文章

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.

    abstract：INTRODUCTION:Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serve...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-014-0414-3

    authors： Snir O,Gomez-Cabrero D,Montes A,Perez-Pampin E,Gómez-Reino JJ,Seddighzadeh M,Klich KU,Israelsson L,Ding B,Catrina AI,Holmdahl R,Alfredsson L,Klareskog L,Tegnér J,Gonzalez A,Malmström V,Padyukov L

    更新日期：2014-08-20 00:00:00

  • Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage.

    abstract：BACKGROUND:Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) in...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-1820-3

    authors： He S,Liu X,Lin Z,Liu Y,Gu L,Zhou H,Tang W,Zuo J

    更新日期：2019-01-29 00:00:00

  • Impact of body weight on the achievement of minimal disease activity in patients with rheumatic diseases: a systematic review and meta-analysis.

    abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s13075-016-1194-8

    authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

    更新日期：2016-12-13 00:00:00

  • The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.

    abstract：INTRODUCTION:The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and potency for IL-6 receptor (IL-6R), combined with an extended half-life by targeting human serum a...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0651-0

    authors： Van Roy M,Ververken C,Beirnaert E,Hoefman S,Kolkman J,Vierboom M,Breedveld E,'t Hart B,Poelmans S,Bontinck L,Hemeryck A,Jacobs S,Baumeister J,Ulrichts H

    更新日期：2015-05-20 00:00:00

  • The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients.

    abstract：INTRODUCTION:HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patients are also characteri...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0881-1

    authors： Lenna S,Assassi S,Farina GA,Mantero JC,Scorza R,Lafyatis R,Farber HW,Trojanowska M

    更新日期：2015-12-16 00:00:00

  • Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.

    abstract：:Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2019

    authors： Kinderlerer AR,Steinberg R,Johns M,Harten SK,Lidington EA,Haskard DO,Maxwell PH,Mason JC

    更新日期：2006-01-01 00:00:00

  • Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

    abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2066-9

    authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

    更新日期：2019-12-16 00:00:00

  • Novel autoantibodies and clinical phenotypes in adult and juvenile myositis.

    abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3275

    authors： Betteridge ZE,Gunawardena H,McHugh NJ

    更新日期：2011-03-18 00:00:00

  • Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs.

    abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3459

    authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

    更新日期：2011-01-01 00:00:00

  • Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment.

    abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2992

    authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

    更新日期：2010-01-01 00:00:00

  • The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis.

    abstract：:As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has be...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar1894

    authors： Pfander D,Swoboda B,Cramer T

    更新日期：2006-01-01 00:00:00

  • Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice.

    abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3481

    authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

    更新日期：2011-01-01 00:00:00

  • TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.

    abstract：:Cartilage damage in osteoarthritis (OA) is considered an imbalance between catabolic and anabolic factors, favoring the catabolic side. We assessed whether adenoviral overexpression of transforming growth factor-beta (TGFbeta) enhanced cartilage repair and whether TGFbeta-induced fibrosis was blocked by local expressi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1931

    authors： Blaney Davidson EN,Vitters EL,van den Berg WB,van der Kraan PM

    更新日期：2006-01-01 00:00:00

  • What can chronic arthritis pain teach about developing new analgesic drugs?

    abstract：:Chronic pain remains an important public health need with greater impact on the US economy than most other chronic conditions. Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs, indicating a gap in the translation of new knowledge to the development of improved pain treatm...

    journal_title：Arthritis research & therapy

    pub_type： 社论

    doi：10.1186/ar1450

    authors： Witter J,Dionne RA

    更新日期：2004-01-01 00:00:00

  • More about masitinib.

    abstract：:A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 responses in 54%, 26% and 8% of patients, respectively. A placebo group was not included. Thirty-seven per cent of...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2734

    authors： Walker UA

    更新日期：2009-01-01 00:00:00

  • Fractional clearance of urate: validation of measurement in spot-urine samples in healthy subjects and gouty patients.

    abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/ar4020

    authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

    更新日期：2012-08-17 00:00:00

  • Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort.

    abstract：BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canad...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2091-8

    authors： Henrey A,Rypdal V,Rypdal M,Loughin T,Nordal E,Guzman J,ReACCh-Out and NoSPeR Investigators.

    更新日期：2020-01-15 00:00:00

  • The synovial proteome: analysis of fibroblast-like synoviocytes.

    abstract：:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1153

    authors： Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

    更新日期：2004-01-01 00:00:00

  • Videoradiographic analysis of the range of motion in unilateral experimental knee joint arthritis in rats.

    abstract：INTRODUCTION:The translational and predictive value of animal models highly depends on the validity of respective readout parameters. In arthritis research, there has been a shift from sole threshold testing for pain-related behavior, as well as from swelling and histology assessment for inflammation, toward an analysi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3342

    authors： Boettger MK,Leuchtweis J,Schaible HG,Schmidt M

    更新日期：2011-05-27 00:00:00

  • Individual and occupational risk factors for knee osteoarthritis: results of a case-control study in Germany.

    abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3015

    authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

    更新日期：2010-01-01 00:00:00

  • A randomized, controlled trial of interferon-beta-1a (Avonex(R)) in patients with rheumatoid arthritis: a pilot study [ISRCTN03626626].

    abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1026

    authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

    更新日期：2004-01-01 00:00:00

  • Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.

    abstract：INTRODUCTION:The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this study was t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2590

    authors： Li Y,Lee PY,Sobel ES,Narain S,Satoh M,Segal MS,Reeves WH,Richards HB

    更新日期：2009-01-01 00:00:00

  • Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.

    abstract：BACKGROUND:Nearly all secreted proteins are glycosylated, and serum glycoproteins that exhibit disease-associated glycosylation changes have potential to be biomarkers. In rheumatoid arthritis (RA), C-reactive protein (CRP), and matrix metalloproteinase-3 (MMP-3) are widely used as serologic biomarkers, but they lack s...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-1013-2

    authors： Takeshita M,Kuno A,Suzuki K,Matsuda A,Shimazaki H,Nakagawa T,Otomo Y,Kabe Y,Suematsu M,Narimatsu H,Takeuchi T

    更新日期：2016-05-21 00:00:00

  • JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix.

    abstract：BACKGROUND:Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensatory response that maintains the necessary resident nucleus pulposus (NP) cell proliferation to repla...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-1990-z

    authors： Long J,Wang X,Du X,Pan H,Wang J,Li Z,Liu H,Li X,Zheng Z

    更新日期：2019-10-16 00:00:00

  • Reproducibility and sensitivity to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval.

    abstract：:Joint space width (JSW) and narrowing (JSN) measurements on radiographs are currently the best way to assess disease severity or progression in hip osteoarthritis, yet we lack data regarding the most accurate and sensitive measurement technique. This study was conducted to determine the optimal radiograph and number o...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/ar1831

    authors： Maheu E,Cadet C,Marty M,Dougados M,Ghabri S,Kerloch I,Mazières B,Spector TD,Vignon E,Lequesne MG

    更新日期：2005-01-01 00:00:00

  • Resistin in idiopathic inflammatory myopathies.

    abstract：INTRODUCTION:The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. METHODS:Serum resistin levels were determin...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3836

    authors： Filková M,Hulejová H,Kuncová K,Pleštilová L,Cerezo LA,Mann H,Klein M,Zámečník J,Gay S,Vencovský J,Senolt L

    更新日期：2012-05-11 00:00:00

  • A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis.

    abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13075-019-1888-9

    authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

    更新日期：2019-04-11 00:00:00

  • Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model.

    abstract：INTRODUCTION:The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have been proven to play an important role in the ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-014-0488-y

    authors： Kawanishi Y,Nakasa T,Shoji T,Hamanishi M,Shimizu R,Kamei N,Usman MA,Ochi M

    更新日期：2014-11-28 00:00:00

  • The changing landscape of the clinical value of the PM/Scl autoantibody system.

    abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2646

    authors： Mahler M,Fritzler MJ

    更新日期：2009-01-01 00:00:00

  • Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis.

    abstract：INTRODUCTION:BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recogniz...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3165

    authors： Charpin C,Martin M,Balandraud N,Roudier J,Auger I

    更新日期：2010-01-01 00:00:00