Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies.

abstract：BACKGROUND:Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. METHODS:For this retrospective cohort analys...

journal_title：Arthritis research & therapy

authors： Grabner M,Boytsov NN,Huang Q,Zhang X,Yan T,Curtis JR

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：BACKGROUND:To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome. METHODS:Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002...

journal_title：Arthritis research & therapy

authors： Heiligenhaus A,Klotsche J,Niewerth M,Horneff G,Ganser G,Haas JP,Minden K

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS. METHODS:The Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDISCUS (through April 2009) and the re...

journal_title：Arthritis research & therapy

authors： Häuser W,Klose P,Langhorst J,Moradi B,Steinbach M,Schiltenwolf M,Busch A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to ...

journal_title：Arthritis research & therapy

authors： Zayed N,Li X,Chabane N,Benderdour M,Martel-Pelletier J,Pelletier JP,Duval N,Fahmi H

更新日期：2008-01-01 00:00:00

abstract：:A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature ...

journal_title：Arthritis research & therapy

authors： Abraham D,Distler O

更新日期：2007-01-01 00:00:00

abstract：:Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the s...

journal_title：Arthritis research & therapy

authors： Buskila D,Sarzi-Puttini P

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition with anakinra, an IL-1 receptor antagonist, improves clinical symptoms and inflammatory markers. Subc...

journal_title：Arthritis research & therapy

authors： Kuemmerle-Deschner JB,Wittkowski H,Tyrrell PN,Koetter I,Lohse P,Ummenhofer K,Reess F,Hansmann S,Koitschev A,Deuter C,Bialkowski A,Foell D,Benseler SM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has been well de...

journal_title：Arthritis research & therapy

authors： Mattyasovszky SG,Hofmann A,Brochhausen C,Ritz U,Kuhn S,Wollstädter J,Schulze-Koops H,Müller LP,Watzer B,Rommens PM

更新日期：2010-01-01 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：:This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (molecular target, isotype, registered indication for JIA, route of administration, half-life, contraindication...

journal_title：Arthritis research & therapy

authors： Swart JF,de Roock S,Wulffraat NM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have been proven to play an important role in the ...

journal_title：Arthritis research & therapy

authors： Kawanishi Y,Nakasa T,Shoji T,Hamanishi M,Shimizu R,Kamei N,Usman MA,Ochi M

更新日期：2014-11-28 00:00:00

abstract：BACKGROUND:In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the steady state level of disease activity (DA) in patients with systemic sclerosis (SSc) when the Europ...

journal_title：Arthritis research & therapy

authors： Pignataro F,Maglione W,Minniti A,Sambataro D,Sambataro G,Campanaro F,Valentini G,Vitali C,Del Papa N

更新日期：2019-11-29 00:00:00

abstract：:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

journal_title：Arthritis research & therapy

authors： Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to examine the expression profiles of IL-29 in blood, synovial fluid (SF) and synovium in RA patients...

journal_title：Arthritis research & therapy

authors： Wang F,Xu L,Feng X,Guo D,Tan W,Zhang M

更新日期：2012-10-19 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice w...

journal_title：Arthritis research & therapy

authors： Li H,Ding X,Terkeltaub R,Lin H,Zhang Y,Zhou B,He K,Li K,Liu Z,Wei J,Yang Y,Xie H,Zeng C,Lei G

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

journal_title：Arthritis research & therapy

authors： Ota T,Ota SI,Uchino A,Nagano S

更新日期：2020-06-26 00:00:00

abstract：INTRODUCTION:In many patients with rheumatoid arthritis (RA) subclinical disease activity can be detected with ultrasound (US), especially using power Doppler US (PDUS). However, PDUS may be highly dependent on the type of machine. This could create problems both in clinical trials and in daily clinical practice. To cl...

journal_title：Arthritis research & therapy

authors： Ten Cate DF,Luime JJ,van der Ven M,Hazes JM,Kooiman K,de Jong N,Bosch JG

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

journal_title：Arthritis research & therapy

authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

更新日期：2016-04-12 00:00:00

abstract：OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who ...

journal_title：Arthritis research & therapy

authors： Chen J,Luo Y,Zhao M,Wu D,Yang Y,Zhang W,Shen M

更新日期：2019-11-12 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

journal_title：Arthritis research & therapy

authors： Moulton VR,Tsokos GC

更新日期：2011-03-17 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

journal_title：Arthritis research & therapy

authors： Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a me...

journal_title：Arthritis research & therapy

authors： Corallo C,Cutolo M,Kahaleh B,Pecetti G,Montella A,Chirico C,Soldano S,Nuti R,Giordano N

更新日期：2016-10-06 00:00:00

abstract：:Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate. We hypothesised that this is due to accelerate...

journal_title：Arthritis research & therapy

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:IL-10 is a very important anti-inflammatory cytokine. However, the role of this cytokine in T cells in the pathogenesis of collagen-induced arthritis is unclear. The purpose of this study was to define the role of IL-10 signaling in T cells in the pathogenesis of collagen-induced arthritis. METHODS:IL-10 ...

journal_title：Arthritis research & therapy

authors： Tao J,Kamanaka M,Hao J,Hao Z,Jiang X,Craft JE,Flavell RA,Wu Z,Hong Z,Zhao L,Yin Z

更新日期：2011-01-01 00:00:00

abstract：:The accumulation of T cells in the synovial membrane is the crucial step in the pathophysiology of the inflammatory processes characterizing juvenile idiopathic arthritis (JIA). In this study, we evaluated the expression and the pathogenetic role in oligoarticular JIA of a CXC chemokine involved in the directional mig...

journal_title：Arthritis research & therapy

authors： Martini G,Zulian F,Calabrese F,Bortoli M,Facco M,Cabrelle A,Valente M,Zacchello F,Agostini C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previously reported that tofacitinib, a JAK inhibitor, facilitates the expansion of myeloid-derived suppres...

journal_title：Arthritis research & therapy

authors： Sendo S,Saegusa J,Yamada H,Nishimura K,Morinobu A

更新日期：2019-08-06 00:00:00