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The synovial proteome: analysis of fibroblast-like synoviocytes.

Abstract：

:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ionization mass spectrometry. A total of 368 spots were examined and 254 identifications were made. The studies identified a number of proteins that have been implicated in the normal or pathological FLS function (e.g. uridine diphosphoglucose dehydrogenase, galectin 1 and galectin 3) or that have been characterized as potential autoantigens in rheumatoid arthritis (e.g. BiP, colligin, HC gp-39). A novel uncharacterized protein product of chromosome 19 open reading frame 10 was also detected as an apparently major component of FLS cells. These results demonstrate the utility of high-content proteomic approaches in the analysis of FLS composition.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

doi

10.1186/ar1153

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

R161-8

issue

2

eissn

1478-6354

issn

1478-6362

pii

ar1153

journal_volume

6

pub_type

杂志文章

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