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How does endothelial cell injury start? The role of endothelin in systemic sclerosis.

Abstract：

:A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Abraham D,Distler O

doi

10.1186/ar2186

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

S2

eissn

1478-6354

issn

1478-6362

pii

ar2186

journal_volume

9 Suppl 2

pub_type

杂志文章,评审

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