Neural immune pathways and their connection to inflammatory diseases.

abstract：INTRODUCTION:It is known that anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we studied ACPA-negative arthralgia patients who were considered prone to progress to RA for local sub...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Huizinga TW,Reijnierse M,van der Helm-van Mil AH

更新日期：2014-04-10 00:00:00

abstract：INTRODUCTION:The effect of low-intensity pulsed ultrasound (LIPUS) on cell growth was examined in three-dimensional-cultured chondrocytes with a collagen sponge. To elucidate the mechanisms underlying the mechanical activation of chondrocytes, intracellular signaling pathways through the Ras/mitogen-activated protein k...

journal_title：Arthritis research & therapy

authors： Takeuchi R,Ryo A,Komitsu N,Mikuni-Takagaki Y,Fukui A,Takagi Y,Shiraishi T,Morishita S,Yamazaki Y,Kumagai K,Aoki I,Saito T

更新日期：2008-01-01 00:00:00

abstract：:There has been some evidence that Behçet's disease (BD) has a significant autoimmune component but the molecular identity of putative autoantigens has not been well characterized. In the initial analysis of the autoantibody profile in 39 Chinese BD patients, autoantibodies to cellular proteins were uncovered in 23% as...

journal_title：Arthritis research & therapy

authors： Lu Y,Ye P,Chen SL,Tan EM,Chan EK

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

journal_title：Arthritis research & therapy

authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

更新日期：2010-01-01 00:00:00

abstract：:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious in...

journal_title：Arthritis research & therapy

authors： Capsoni F,Sarzi-Puttini P,Zanella A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort. METHODS:The magnitude of association for each genotype was assessed in 1,046 RA subjects...

journal_title：Arthritis research & therapy

authors： Morgan AW,Robinson JI,Conaghan PG,Martin SG,Hensor EM,Morgan MD,Steiner L,Erlich HA,Gooi HC,Barton A,Worthington J,Emery P,UKRAG Consortium.,YEAR Consortium.

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to examine data from the Johnston County Osteoarthritis (OA) Project for independent associations of educational attainment, occupation and community poverty with tibiofemoral knee OA. METHODS:A cross-sectional analysis was conducted on 3,591 individuals (66% Caucasian and 34...

journal_title：Arthritis research & therapy

authors： Callahan LF,Cleveland RJ,Shreffler J,Schwartz TA,Schoster B,Randolph R,Renner JB,Jordan JM

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in huma...

journal_title：Arthritis research & therapy

authors： Steinert AF,Weissenberger M,Kunz M,Gilbert F,Ghivizzani SC,Göbel S,Jakob F,Nöth U,Rudert M

更新日期：2012-07-20 00:00:00

abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

journal_title：Arthritis research & therapy

authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

更新日期：2014-07-10 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

journal_title：Arthritis research & therapy

authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

更新日期：2015-08-28 00:00:00

abstract：INTRODUCTION:Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue kne...

journal_title：Arthritis research & therapy

authors： Peat G,Bergknut C,Frobell R,Jöud A,Englund M

更新日期：2014-07-31 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：:Synovial fluid from patients with various arthritides contains procoagulant, cell-derived microparticles. Here we studied whether synovial microparticles modulate the release of chemokines and cytokines by fibroblast-like synoviocytes (FLS). Microparticles, isolated from the synovial fluid of rheumatoid arthritis (RA)...

journal_title：Arthritis research & therapy

authors： Berckmans RJ,Nieuwland R,Kraan MC,Schaap MC,Pots D,Smeets TJ,Sturk A,Tak PP

更新日期：2005-01-01 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and entheses that results in destructive and osteochondral proliferative lesions. There is a need for bio...

journal_title：Arthritis research & therapy

authors： Gudmann NS,Munk HL,Christensen AF,Ejstrup L,Sørensen GL,Loft AG,Karsdal MA,Bay-Jensen AC,He Y,Siebuhr AS,Junker P

更新日期：2016-06-16 00:00:00

abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

journal_title：Arthritis research & therapy

authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Osteoclastogenesis plays an important role in the bone erosion of rheumatoid arthritis (RA). Recently, Notch receptors have been implicated in the development of osteoclasts. However, the responsible Notch ligands have not been identified yet. This study was undertaken to determine the role of individual N...

journal_title：Arthritis research & therapy

authors： Sekine C,Koyanagi A,Koyama N,Hozumi K,Chiba S,Yagita H

更新日期：2012-03-05 00:00:00

abstract：BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

journal_title：Arthritis research & therapy

authors： Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in patients with psoriatic arthritis (PsA) and compare these findings with other radiological scoring ...

journal_title：Arthritis research & therapy

authors： Pfeil A,Krojniak L,Renz DM,Reinhardt L,Franz M,Oelzner P,Wolf G,Böttcher J

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

journal_title：Arthritis research & therapy

authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

更新日期：2020-10-15 00:00:00

abstract：OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who ...

journal_title：Arthritis research & therapy

authors： Chen J,Luo Y,Zhao M,Wu D,Yang Y,Zhang W,Shen M

更新日期：2019-11-12 00:00:00

abstract：INTRODUCTION:Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significantly decreased after treatment. However, little is known about the nature of this cell entity. ...

journal_title：Arthritis research & therapy

authors： Yang HX,Zhang W,Zhao LD,Li Y,Zhang FC,Tang FL,He W,Zhang X

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this study was to investigate the gene expression profiles involved in this process using NP tissue fr...

journal_title：Arthritis research & therapy

authors： Smolders LA,Meij BP,Onis D,Riemers FM,Bergknut N,Wubbolts R,Grinwis GC,Houweling M,Groot Koerkamp MJ,van Leenen D,Holstege FC,Hazewinkel HA,Creemers LB,Penning LC,Tryfonidou MA

更新日期：2013-01-29 00:00:00

abstract：INTRODUCTION:Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell lines or monocytes of ...

journal_title：Arthritis research & therapy

authors： Mylona EE,Mouktaroudi M,Crisan TO,Makri S,Pistiki A,Georgitsi M,Savva A,Netea MG,van der Meer JW,Giamarellos-Bourboulis EJ,Joosten LA

更新日期：2012-07-04 00:00:00

abstract：BACKGROUND:Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore the relationship between multisite pain and falls and to quantify associated risks. METHODS:Bibliog...

journal_title：Arthritis research & therapy

authors： Welsh VK,Clarson LE,Mallen CD,McBeth J

更新日期：2019-02-22 00:00:00

abstract：INTRODUCTION:In this study, we sought to address changes in blood lymphocyte subpopulations and labial salivary gland (LSG) inflammation after belimumab treatment in patients with primary Sjögren's syndrome (pSS) and to identify predictors of response to treatment. METHODS:Sequential blood lymphocyte subsets and LSG b...

journal_title：Arthritis research & therapy

authors： Seror R,Nocturne G,Lazure T,Hendel-Chavez H,Desmoulins F,Belkhir R,Ravaud P,Benbijja M,Poirier-Colame V,Taoufik Y,Mariette X

更新日期：2015-09-04 00:00:00

abstract：INTRODUCTION:There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant anim...

journal_title：Arthritis research & therapy

authors： Vierboom MP,Breedveld E,Kondova I,'t Hart BA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities i...

journal_title：Arthritis research & therapy

authors： Jonsson MK,Hensvold AH,Hansson M,Aga AB,Sexton J,Mathsson-Alm L,Cornillet M,Serre G,Lillegraven S,Fevang BS,Catrina AI,Haavardsholm EA

更新日期：2018-07-13 00:00:00

abstract：:The characteristic of a biomarker that makes it a useful surrogate is the ability to identify a high risk of clinically important benefits or harms occurring in the future. A number of definitions or descriptions of surrogate definition have been put forward. Most recently the Institute of Medicine of the National Aca...

journal_title：Arthritis research & therapy

authors： Andrew Moore R

更新日期：2013-01-01 00:00:00