Identification of kinectin as a novel Behçet's disease autoantigen.

abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

journal_title：Arthritis research & therapy

authors： Mahler M,Fritzler MJ

更新日期：2009-01-01 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：BACKGROUND:In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the steady state level of disease activity (DA) in patients with systemic sclerosis (SSc) when the Europ...

journal_title：Arthritis research & therapy

authors： Pignataro F,Maglione W,Minniti A,Sambataro D,Sambataro G,Campanaro F,Valentini G,Vitali C,Del Papa N

更新日期：2019-11-29 00:00:00

abstract：INTRODUCTION:Inflammatory arthritis is associated with increased bone resorption and suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation and this protein has been proposed to be a master regulator of bone remodelling in inflammatory arthritis. ...

journal_title：Arthritis research & therapy

authors： Hardy R,Juarez M,Naylor A,Tu J,Rabbitt EH,Filer A,Stewart PM,Buckley CD,Raza K,Cooper MS

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

journal_title：Arthritis research & therapy

authors： Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

更新日期：2015-10-23 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：:One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of carbon monoxide) is recommended to detect PAH at a less severe stage. However, real-world screening programs ha...

journal_title：Arthritis research & therapy

authors： Pope JE

更新日期：2017-06-06 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

journal_title：Arthritis research & therapy

authors： Rutgers M,Saris DB,Dhert WJ,Creemers LB

更新日期：2010-01-01 00:00:00

abstract：:Cartilage damage in osteoarthritis (OA) is considered an imbalance between catabolic and anabolic factors, favoring the catabolic side. We assessed whether adenoviral overexpression of transforming growth factor-beta (TGFbeta) enhanced cartilage repair and whether TGFbeta-induced fibrosis was blocked by local expressi...

journal_title：Arthritis research & therapy

authors： Blaney Davidson EN,Vitters EL,van den Berg WB,van der Kraan PM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell lines or monocytes of ...

journal_title：Arthritis research & therapy

authors： Mylona EE,Mouktaroudi M,Crisan TO,Makri S,Pistiki A,Georgitsi M,Savva A,Netea MG,van der Meer JW,Giamarellos-Bourboulis EJ,Joosten LA

更新日期：2012-07-04 00:00:00

abstract：BACKGROUND:With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant ...

journal_title：Arthritis research & therapy

authors： Ochi S,Saito K,Mizoguchi F,Kato S,Tanaka Y

更新日期：2020-03-04 00:00:00

abstract：INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

journal_title：Arthritis research & therapy

authors： De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

更新日期：2011-01-01 00:00:00

abstract：:The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990...

journal_title：Arthritis research & therapy

authors： Boyce BF,Xing L

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：:Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus an...

journal_title：Arthritis research & therapy

authors： Gray SG

更新日期：2013-03-14 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progressi...

journal_title：Arthritis research & therapy

authors： Chapoval SP

更新日期：2015-11-06 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with partic...

journal_title：Arthritis research & therapy

authors： Zhang Z,Ding Y,Li W,Song B,Yang R

更新日期：2013-10-29 00:00:00

abstract：INTRODUCTION:Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serve...

journal_title：Arthritis research & therapy

authors： Snir O,Gomez-Cabrero D,Montes A,Perez-Pampin E,Gómez-Reino JJ,Seddighzadeh M,Klich KU,Israelsson L,Ding B,Catrina AI,Holmdahl R,Alfredsson L,Klareskog L,Tegnér J,Gonzalez A,Malmström V,Padyukov L

更新日期：2014-08-20 00:00:00

abstract：:Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have p...

journal_title：Arthritis research & therapy

authors： Villanueva J,Lee S,Giannini EH,Graham TB,Passo MH,Filipovich A,Grom AA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nu...

journal_title：Arthritis research & therapy

authors： TenBroek EM,Yunker L,Nies MF,Bendele AM

更新日期：2016-01-21 00:00:00

abstract：INTRODUCTION:The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis. METHODS:Human CD14+ cells were isolated fro...

journal_title：Arthritis research & therapy

authors： Adamopoulos IE,Chao CC,Geissler R,Laface D,Blumenschein W,Iwakura Y,McClanahan T,Bowman EP

更新日期：2010-01-01 00:00:00

abstract：:Recent genome-wide association studies have implicated the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor-kappa-B activator 1 (Act1), in the development of psoriatic arthritis (PsA). The high level of sequence homology of the TRAF3IP2 (Act1) gen...

journal_title：Arthritis research & therapy

authors： Doyle MS,Collins ES,FitzGerald OM,Pennington SR

更新日期：2012-10-31 00:00:00

abstract：BACKGROUND:Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and symptoms, including HRQoL, among patients with active PsA. This analysis evaluates the effect of se...

journal_title：Arthritis research & therapy

authors： McInnes IB,Mease PJ,Schett G,Kirkham B,Strand V,Williams N,Fox T,Pricop L,Jugl SM,Gandhi KK,FUTURE 2 Study Group.

更新日期：2018-06-07 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：:Pleiotropic effects are now described for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammat...

journal_title：Arthritis research & therapy

authors： McCarey DW,Sattar N,McInnes IB

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim of this study was to detect the levels of ...

journal_title：Arthritis research & therapy

authors： Wu Y,Zhang F,Ma J,Zhang X,Wu L,Qu B,Xia S,Chen S,Tang Y,Shen N

更新日期：2015-05-21 00:00:00