The changing landscape of the clinical value of the PM/Scl autoantibody system.

abstract：BACKGROUND:Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and symptoms, including HRQoL, among patients with active PsA. This analysis evaluates the effect of se...

journal_title：Arthritis research & therapy

authors： McInnes IB,Mease PJ,Schett G,Kirkham B,Strand V,Williams N,Fox T,Pricop L,Jugl SM,Gandhi KK,FUTURE 2 Study Group.

更新日期：2018-06-07 00:00:00

abstract：INTRODUCTION:Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim of this study was to detect the levels of ...

journal_title：Arthritis research & therapy

authors： Wu Y,Zhang F,Ma J,Zhang X,Wu L,Qu B,Xia S,Chen S,Tang Y,Shen N

更新日期：2015-05-21 00:00:00

abstract：OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who ...

journal_title：Arthritis research & therapy

authors： Chen J,Luo Y,Zhao M,Wu D,Yang Y,Zhang W,Shen M

更新日期：2019-11-12 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the effects of L-4F, an apolipoprotein A-1 mimetic peptide, alone or with pravastatin, in apoE-/-Fas-/-C57BL/6 mice that spontaneously develop immunoglobulin G (IgG) autoantibodies, glomerulonephritis, osteopenia, and atherosclerotic lesions on a normal chow diet. ...

journal_title：Arthritis research & therapy

authors： Woo JM,Lin Z,Navab M,Van Dyck C,Trejo-Lopez Y,Woo KM,Li H,Castellani LW,Wang X,Iikuni N,Rullo OJ,Wu H,La Cava A,Fogelman AM,Lusis AJ,Tsao BP

更新日期：2010-01-01 00:00:00

abstract：:Recent genome-wide association studies have implicated the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor-kappa-B activator 1 (Act1), in the development of psoriatic arthritis (PsA). The high level of sequence homology of the TRAF3IP2 (Act1) gen...

journal_title：Arthritis research & therapy

authors： Doyle MS,Collins ES,FitzGerald OM,Pennington SR

更新日期：2012-10-31 00:00:00

abstract：INTRODUCTION:Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions in ECM degradation and prevents ECM synthesis by down-regulating the key transcription factor, Sox9, and consequently inhibiting ECM gene expressio...

journal_title：Arthritis research & therapy

authors： Dai L,Zhang X,Hu X,Zhou C,Ao Y

更新日期：2012-12-10 00:00:00

abstract：:Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsi...

journal_title：Arthritis research & therapy

authors： Jain V,Gordon C

更新日期：2011-02-25 00:00:00

abstract：INTRODUCTION:The purpose of this study was the evaluation of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (IA) tumor necrosis factor (TNF)-α blockers in psoriatic arthritis (PsA). METHODS:Systemic and lo...

journal_title：Arthritis research & therapy

authors： Fiocco U,Sfriso P,Oliviero F,Roux-Lombard P,Scagliori E,Cozzi L,Lunardi F,Calabrese F,Vezzù M,Dainese S,Molena B,Scanu A,Nardacchione R,Rubaltelli L,Dayer JM,Punzi L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are ...

journal_title：Arthritis research & therapy

authors： Nakagawa J,Koyama Y,Kawakami A,Ueki Y,Tsukamoto H,Horiuchi T,Nagano S,Uchino A,Ota T,Akahoshi M,Akashi K

更新日期：2017-08-11 00:00:00

abstract：INTRODUCTION:Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume measurement in clinically stable patients with tophaceous gout. METHODS:Seventy-three patients wi...

journal_title：Arthritis research & therapy

authors： Rajan A,Aati O,Kalluru R,Gamble GD,Horne A,Doyle AJ,McQueen FM,Dalbeth N

更新日期：2013-10-23 00:00:00

abstract：OBJECTIVE:To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). PATIENTS AND METHODS:This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose...

journal_title：Arthritis research & therapy

authors： Li R,Zhu WJ,Wang F,Tang X,Luo F

更新日期：2020-09-20 00:00:00

abstract：INTRODUCTION:Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA). METHODS:Arthritis was induced by intraperitoneal injection of a collagen antibody cocktail into properdin-deficient (KO) and w...

journal_title：Arthritis research & therapy

authors： Dimitrova P,Ivanovska N,Belenska L,Milanova V,Schwaeble W,Stover C

更新日期：2012-07-25 00:00:00

abstract：:The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA) remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently, murine models of arthritis are induced by imm...

journal_title：Arthritis research & therapy

authors： Kamradt T,Schubert D

更新日期：2005-01-01 00:00:00

abstract：:Human T cell leukaemia virus type I (HTLV-I) is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However, it is unclear whether HTLV-I infection could modify the pathophysiology of osteoarthritis (OA). In this study we compared several inflammatory cytokines, such as C-termina...

journal_title：Arthritis research & therapy

authors： Yoshihara Y,Tsukazaki T,Osaki M,Nakashima M,Hasui K,Shindo H

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Osteoclastogenesis plays an important role in the bone erosion of rheumatoid arthritis (RA). Recently, Notch receptors have been implicated in the development of osteoclasts. However, the responsible Notch ligands have not been identified yet. This study was undertaken to determine the role of individual N...

journal_title：Arthritis research & therapy

authors： Sekine C,Koyanagi A,Koyama N,Hozumi K,Chiba S,Yagita H

更新日期：2012-03-05 00:00:00

abstract：INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 ...

journal_title：Arthritis research & therapy

authors： Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

更新日期：2012-01-18 00:00:00

abstract：:Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review ...

journal_title：Arthritis research & therapy

authors： Ramiro S,Machado P,Singh JA,Landewé RB,da Silva JA

更新日期：2010-01-01 00:00:00

abstract：:Autoantibodies to neutrophil cytoplasmic antigen-associated vasculitis (AAV) is characterised by inflammation of blood vessels. The introduction of immunosuppressive therapy with glucocorticoids and cyclophosphamide transformed AAV from a fatal condition to a largely treatable condition. Over the past 30 years, consid...

journal_title：Arthritis research & therapy

authors： Smith RM,Jones RB,Jayne DR

更新日期：2012-04-30 00:00:00

abstract：INTRODUCTION:The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host-pathogen interactions are involv...

journal_title：Arthritis research & therapy

authors： Jaen O,Petit-Teixeira E,Kirsten H,Ahnert P,Semerano L,Pierlot C,Cornelis F,Boissier MC,Falgarone G,European Consortium on Rheumatoid Arthritis Families.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with partic...

journal_title：Arthritis research & therapy

authors： Zhang Z,Ding Y,Li W,Song B,Yang R

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

journal_title：Arthritis research & therapy

authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

更新日期：2020-10-15 00:00:00

abstract：INTRODUCTION:The objective of this study was to assess natural microbial agents, history and risk factors for total joint arthroplasty (TJA) infections in patients receiving tumor necrosis factor (TNF)α-blockers, through the French RATIO registry and a case-control study. METHODS:Cases were TJA infections during TNFα-...

journal_title：Arthritis research & therapy

authors： Gilson M,Gossec L,Mariette X,Gherissi D,Guyot MH,Berthelot JM,Wendling D,Michelet C,Dellamonica P,Tubach F,Dougados M,Salmon D

更新日期：2010-01-01 00:00:00

abstract：:Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the s...

journal_title：Arthritis research & therapy

authors： Buskila D,Sarzi-Puttini P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

journal_title：Arthritis research & therapy

authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

更新日期：2015-04-15 00:00:00

abstract：INTRODUCTION:BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recogniz...

journal_title：Arthritis research & therapy

authors： Charpin C,Martin M,Balandraud N,Roudier J,Auger I

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, we examined whether C/EBPβ mediates the expression of receptor activator of nuclear factor-kappa-B ...

journal_title：Arthritis research & therapy

authors： Tsushima H,Okazaki K,Ishihara K,Ushijima T,Iwamoto Y

更新日期：2015-02-17 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

journal_title：Arthritis research & therapy

authors： Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

更新日期：2021-01-13 00:00:00

abstract：INTRODUCTION:There is a suspicion of increased risk of Epstein-Barr virus (EBV)-associated lymphoproliferations in patients with inflammatory arthritides receiving immunosuppressive drugs. We investigated the EBV load and EBV-specific T-cell response in patients treated with methotrexate (MTX) or anti-TNF therapy. MET...

journal_title：Arthritis research & therapy

authors： Miceli-Richard C,Gestermann N,Amiel C,Sellam J,Ittah M,Pavy S,Urrutia A,Girauld I,Carcelain G,Venet A,Mariette X

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

journal_title：Arthritis research & therapy

authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

更新日期：2010-01-01 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00