A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study.

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：:Cartilage damage in osteoarthritis (OA) is considered an imbalance between catabolic and anabolic factors, favoring the catabolic side. We assessed whether adenoviral overexpression of transforming growth factor-beta (TGFbeta) enhanced cartilage repair and whether TGFbeta-induced fibrosis was blocked by local expressi...

journal_title：Arthritis research & therapy

authors： Blaney Davidson EN,Vitters EL,van den Berg WB,van der Kraan PM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations in the T lymphocyte compartment and dysregulated cytokine production are key features of SLE pathogenesis and disease progression. Recently...

journal_title：Arthritis research & therapy

authors： Puwipirom H,Hirankarn N,Sodsai P,Avihingsanon Y,Wongpiyabovorn J,Palaga T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes during OA pathogenesis....

journal_title：Arthritis research & therapy

authors： Li J,Huang J,Dai L,Yu D,Chen Q,Zhang X,Dai K

更新日期：2012-04-16 00:00:00

abstract：:Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

journal_title：Arthritis research & therapy

authors： Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:Rituximab (RTX) therapy of rheumatoid arthritis (RA) exhibits enhanced effectiveness in seropositive patients. Using patient sera, we tested if this improved efficacy was associated with enhanced RTX mediated complement-dependent cytotoxicity (RTX-CDC). METHODS:We developed an in vitro assay for RTX-CDC u...

journal_title：Arthritis research & therapy

authors： Jones JD,Shyu I,Newkirk MM,Rigby WF

更新日期：2013-01-25 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) antagonists reduce the signs and symptoms of spondyloarthritides, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Our objective was to evaluate the effectiveness and safety of adalimumab, 40 mg every other week, for patients with AS or PsA and prior treatmen...

journal_title：Arthritis research & therapy

authors： Rudwaleit M,Van den Bosch F,Kron M,Kary S,Kupper H

更新日期：2010-01-01 00:00:00

abstract：:Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of com...

journal_title：Arthritis research & therapy

authors： Cortes A,Brown MA

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to examine data from the Johnston County Osteoarthritis (OA) Project for independent associations of educational attainment, occupation and community poverty with tibiofemoral knee OA. METHODS:A cross-sectional analysis was conducted on 3,591 individuals (66% Caucasian and 34...

journal_title：Arthritis research & therapy

authors： Callahan LF,Cleveland RJ,Shreffler J,Schwartz TA,Schoster B,Randolph R,Renner JB,Jordan JM

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE ...

journal_title：Arthritis research & therapy

authors： Meyer PW,Hodkinson B,Ally M,Musenge E,Wadee AA,Fickl H,Tikly M,Anderson R

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

journal_title：Arthritis research & therapy

authors： Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

更新日期：2020-08-12 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

journal_title：Arthritis research & therapy

authors： Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

更新日期：2014-10-30 00:00:00

abstract：:Experimental arthritis models are considered valuable tools for delineating mechanisms of inflammation and autoimmune phenomena. Use of microarray-based methods represents a new and challenging approach that allows molecular dissection of complex autoimmune diseases such as arthritis. In order to characterize the temp...

journal_title：Arthritis research & therapy

authors： Rioja I,Clayton CL,Graham SJ,Life PF,Dickson MC

更新日期：2005-01-01 00:00:00

abstract：:Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7alpha-hydroxy-dehydroepiandrosterone (7alpha-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone, can block glucocorticoid-induced immune suppression. Formation of 7alpha-OH-DHEA is catalyzed by act...

journal_title：Arthritis research & therapy

authors： Dulos J,Kaptein A,Kavelaars A,Heijnen C,Boots A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：:With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a cen...

journal_title：Arthritis research & therapy

authors： Walmsley SR,Chilvers ER,Whyte MK

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tightly orchestrated process dependent on several factors, including the balance between receptor acti...

journal_title：Arthritis research & therapy

authors： Carmona-Fernandes D,Santos MJ,Perpétuo IP,Fonseca JE,Canhão H

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. METHODS:Serum resistin levels were determin...

journal_title：Arthritis research & therapy

authors： Filková M,Hulejová H,Kuncová K,Pleštilová L,Cerezo LA,Mann H,Klein M,Zámečník J,Gay S,Vencovský J,Senolt L

更新日期：2012-05-11 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00

abstract：:Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the influence of epigenetic processes on the development of rheumatic diseases is probably as strong as the genetic ...

journal_title：Arthritis research & therapy

authors： Strietholt S,Maurer B,Peters MA,Pap T,Gay S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE:To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active ...

journal_title：Arthritis research & therapy

authors： Glimm AM,Sprenger LI,Haugen IK,Mansmann U,Hermann S,Häupl T,Hoff P,Burmester GR,Backhaus M,Le L,Ohrndorf S

更新日期：2019-09-18 00:00:00

abstract：INTRODUCTION:Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sl...

journal_title：Arthritis research & therapy

authors： Lee YC,Chibnik LB,Lu B,Wasan AD,Edwards RR,Fossel AH,Helfgott SM,Solomon DH,Clauw DJ,Karlson EW

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model. METHODS:Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg oral spironolactone or vehicle. Proteinuria...

journal_title：Arthritis research & therapy

authors： Monrad SU,Killen PD,Anderson MR,Bradke A,Kaplan MJ

更新日期：2008-01-01 00:00:00

abstract：:The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990...

journal_title：Arthritis research & therapy

authors： Boyce BF,Xing L

更新日期：2007-01-01 00:00:00

abstract：:Synovial biomarker analysis in rheumatoid arthritis can be used to evaluate drug effect in clinical trials of novel therapeutic agents. Previous studies of synovial gene expression for these studies have mainly relied on histological methods including immunohistochemistry and in situ hybridization. To increase the rel...

journal_title：Arthritis research & therapy

authors： Boyle DL,Rosengren S,Bugbee W,Kavanaugh A,Firestein GS

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis in a cohort of Mexican Mestizo early RA patients, and to define a causal association between MetS...

journal_title：Arthritis research & therapy

authors： Parra-Salcedo F,Contreras-Yáñez I,Elías-López D,Aguilar-Salinas CA,Pascual-Ramos V

更新日期：2015-02-20 00:00:00