Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project.

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

journal_title：Arthritis research & therapy

authors： Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

更新日期：2020-08-12 00:00:00

abstract：INTRODUCTION:It is known that anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we studied ACPA-negative arthralgia patients who were considered prone to progress to RA for local sub...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Huizinga TW,Reijnierse M,van der Helm-van Mil AH

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE:To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active ...

journal_title：Arthritis research & therapy

authors： Glimm AM,Sprenger LI,Haugen IK,Mansmann U,Hermann S,Häupl T,Hoff P,Burmester GR,Backhaus M,Le L,Ohrndorf S

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：BACKGROUND:The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the 2010 classification criteria for rheumatoid arthritis (RA). However, a considerable number of RA pa...

journal_title：Arthritis research & therapy

authors： Boeters DM,Trouw LA,van der Helm-van Mil AHM,van Steenbergen HW

更新日期：2018-05-03 00:00:00

abstract：:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

journal_title：Arthritis research & therapy

authors： Krane SM

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destruction, an...

journal_title：Arthritis research & therapy

authors： Atkinson SM,Bleil J,Maier R,Kühl AA,Thorn M,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A,Syrbe U

更新日期：2016-01-23 00:00:00

abstract：INTRODUCTION:The patient's perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication attributes, and to establish how patients trade between these attributes. METHODS:A discrete choic...

journal_title：Arthritis research & therapy

authors： Hiligsmann M,Dellaert BG,Dirksen CD,van der Weijden T,Goemaere S,Reginster JY,Watson V,Boonen A

更新日期：2014-01-31 00:00:00

abstract：BACKGROUND:Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destruction. The objective of this study was to decipher the link between autophagy and regulatory mechanism o...

journal_title：Arthritis research & therapy

authors： Wang F,Liu J,Chen X,Zheng X,Qu N,Zhang B,Xia C

更新日期：2019-07-10 00:00:00

abstract：BACKGROUND:To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome. METHODS:Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002...

journal_title：Arthritis research & therapy

authors： Heiligenhaus A,Klotsche J,Niewerth M,Horneff G,Ganser G,Haas JP,Minden K

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

journal_title：Arthritis research & therapy

authors： Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

更新日期：2012-04-30 00:00:00

abstract：:It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of th...

journal_title：Arthritis research & therapy

authors： Sherlock JP,Filer AD,Isaacs JD,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant ...

journal_title：Arthritis research & therapy

authors： Bagnato G,Bitto A,Irrera N,Pizzino G,Sangari D,Cinquegrani M,Roberts W,Atteritano M,Altavilla D,Squadrito F,Bagnato G,Saitta A

更新日期：2013-09-16 00:00:00

abstract：:Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial h...

journal_title：Arthritis research & therapy

authors： Bauer K,Knipper A,Tu-Rapp H,Koczan D,Kreutzer HJ,Nizze H,Mix E,Thiesen HJ,Holmdahl R,Ibrahim SM

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 + CXCR3-CCR6- (Tfh-Th2) and CXCR5 + CXCR3-CCR6+ (Tfh-Th17). Our objective was to study the B cell ...

journal_title：Arthritis research & therapy

authors： Arroyo-Villa I,Bautista-Caro MB,Balsa A,Aguado-Acín P,Bonilla-Hernán MG,Plasencia C,Villalba A,Nuño L,Puig-Kröger A,Martín-Mola E,Miranda-Carús ME

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies have investigated the long-term stru...

journal_title：Arthritis research & therapy

authors： Wu D,Griffith JF,Lam SHM,Wong PCH,Shi L,Li EK,Cheng IT,Li TK,Hung VW,Qin L,Tam LS

更新日期：2019-12-04 00:00:00

abstract：INTRODUCTION:Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS...

journal_title：Arthritis research & therapy

authors： Duijnisveld BJ,Bigot A,Beenakker KG,Portilho DM,Raz V,van der Heide HJ,Visser CP,Chaouch S,Mamchaoui K,Westendorp RG,Mouly V,Butler-Browne GS,Nelissen RG,Maier AB

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

journal_title：Arthritis research & therapy

authors： Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. METHODS:Serum resistin levels were determin...

journal_title：Arthritis research & therapy

authors： Filková M,Hulejová H,Kuncová K,Pleštilová L,Cerezo LA,Mann H,Klein M,Zámečník J,Gay S,Vencovský J,Senolt L

更新日期：2012-05-11 00:00:00

abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

journal_title：Arthritis research & therapy

authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

更新日期：2021-01-19 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：:Recent genome-wide association studies have implicated the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor-kappa-B activator 1 (Act1), in the development of psoriatic arthritis (PsA). The high level of sequence homology of the TRAF3IP2 (Act1) gen...

journal_title：Arthritis research & therapy

authors： Doyle MS,Collins ES,FitzGerald OM,Pennington SR

更新日期：2012-10-31 00:00:00

abstract：:We analyzed the clinical response and the time to relapse after discontinuation of continuous long-term infliximab therapy in patients with ankylosing spondylitis (AS). After 3 years of infliximab therapy, all AS patients (n = 42) discontinued treatment (time point (TP)1) and were visited regularly for 1 year in order...

journal_title：Arthritis research & therapy

authors： Baraliakos X,Listing J,Brandt J,Zink A,Alten R,Burmester G,Gromnica-Ihle E,Kellner H,Schneider M,Sörensen H,Zeidler H,Rudwaleit M,Sieper J,Braun J

更新日期：2005-01-01 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progressi...

journal_title：Arthritis research & therapy

authors： Chapoval SP

更新日期：2015-11-06 00:00:00

abstract：INTRODUCTION:In this study, we sought to address changes in blood lymphocyte subpopulations and labial salivary gland (LSG) inflammation after belimumab treatment in patients with primary Sjögren's syndrome (pSS) and to identify predictors of response to treatment. METHODS:Sequential blood lymphocyte subsets and LSG b...

journal_title：Arthritis research & therapy

authors： Seror R,Nocturne G,Lazure T,Hendel-Chavez H,Desmoulins F,Belkhir R,Ravaud P,Benbijja M,Poirier-Colame V,Taoufik Y,Mariette X

更新日期：2015-09-04 00:00:00

abstract：:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

journal_title：Arthritis research & therapy

authors： Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) antagonists reduce the signs and symptoms of spondyloarthritides, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Our objective was to evaluate the effectiveness and safety of adalimumab, 40 mg every other week, for patients with AS or PsA and prior treatmen...

journal_title：Arthritis research & therapy

authors： Rudwaleit M,Van den Bosch F,Kron M,Kary S,Kupper H

更新日期：2010-01-01 00:00:00

abstract：:The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased synovial vascularity, and henc...

journal_title：Arthritis research & therapy

authors： Bainbridge J,Madden L,Essex D,Binks M,Malhotra R,Paleolog EM

更新日期：2007-01-01 00:00:00