What can rheumatologists learn from translational cancer therapy?

abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

journal_title：Arthritis research & therapy

authors： Gaffo AL,Saag KG

更新日期：2008-01-01 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canad...

journal_title：Arthritis research & therapy

authors： Henrey A,Rypdal V,Rypdal M,Loughin T,Nordal E,Guzman J,ReACCh-Out and NoSPeR Investigators.

更新日期：2020-01-15 00:00:00

abstract：INTRODUCTION:Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats-suggesting it may be a potent drug for rheumatoid arthritis (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocyte...

journal_title：Arthritis research & therapy

authors： Ma JD,Jing J,Wang JW,Yan T,Li QH,Mo YQ,Zheng DH,Gao JL,Nguyen KA,Dai L

更新日期：2019-06-24 00:00:00

abstract：INTRODUCTION:NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflammasome. Although some ...

journal_title：Arthritis research & therapy

authors： Ito S,Hara Y,Kubota T

更新日期：2014-02-12 00:00:00

abstract：:The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased synovial vascularity, and henc...

journal_title：Arthritis research & therapy

authors： Bainbridge J,Madden L,Essex D,Binks M,Malhotra R,Paleolog EM

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase ...

journal_title：Arthritis research & therapy

authors： Lee SI,Boyle DL,Berdeja A,Firestein GS

更新日期：2012-02-21 00:00:00

abstract：BACKGROUND:The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the 2010 classification criteria for rheumatoid arthritis (RA). However, a considerable number of RA pa...

journal_title：Arthritis research & therapy

authors： Boeters DM,Trouw LA,van der Helm-van Mil AHM,van Steenbergen HW

更新日期：2018-05-03 00:00:00

abstract：INTRODUCTION:Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that...

journal_title：Arthritis research & therapy

authors： Klingberg E,Lorentzon M,Göthlin J,Mellström D,Geijer M,Ohlsson C,Atkinson EJ,Khosla S,Carlsten H,Forsblad-d'Elia H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory find...

journal_title：Arthritis research & therapy

authors： Sugiyama Y,Yoshimi R,Tamura M,Takeno M,Kunishita Y,Kishimoto D,Yoshioka Y,Kobayashi K,Takase-Minegishi K,Watanabe T,Hamada N,Nagai H,Tsuchida N,Soejima Y,Nakano H,Kamiyama R,Uehara T,Kirino Y,Sekiguchi A,Ihata A,O

更新日期：2018-01-11 00:00:00

abstract：:Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have p...

journal_title：Arthritis research & therapy

authors： Villanueva J,Lee S,Giannini EH,Graham TB,Passo MH,Filipovich A,Grom AA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

journal_title：Arthritis research & therapy

authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:Studies in the spontaneous ankylosis model in aging male DBA/1 mice and in patients with ankylosing spondylitis provide evidence that inflammation and new tissue formation leading to joint or spine ankylosis are likely linked but largely uncoupled processes. We previously proposed the 'entheseal stress' hy...

journal_title：Arthritis research & therapy

authors： Braem K,Deroose CM,Luyten FP,Lories RJ

更新日期：2012-03-12 00:00:00

abstract：:The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4...

journal_title：Arthritis research & therapy

authors： McCormack WJ,Parker AE,O'Neill LA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis in a cohort of Mexican Mestizo early RA patients, and to define a causal association between MetS...

journal_title：Arthritis research & therapy

authors： Parra-Salcedo F,Contreras-Yáñez I,Elías-López D,Aguilar-Salinas CA,Pascual-Ramos V

更新日期：2015-02-20 00:00:00

abstract：:Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic factors, particularly the presence of HLA-B27, are major contributors to the susceptibility for AS. Despite s...

journal_title：Arthritis research & therapy

authors： Peloso PM,Braun J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00

abstract：INTRODUCTION:The patient's perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication attributes, and to establish how patients trade between these attributes. METHODS:A discrete choic...

journal_title：Arthritis research & therapy

authors： Hiligsmann M,Dellaert BG,Dirksen CD,van der Weijden T,Goemaere S,Reginster JY,Watson V,Boonen A

更新日期：2014-01-31 00:00:00

abstract：:One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of carbon monoxide) is recommended to detect PAH at a less severe stage. However, real-world screening programs ha...

journal_title：Arthritis research & therapy

authors： Pope JE

更新日期：2017-06-06 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：:As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has be...

journal_title：Arthritis research & therapy

authors： Pfander D,Swoboda B,Cramer T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are involved in IIM, and the functional relationship between autoantib...

journal_title：Arthritis research & therapy

authors： Parkes JE,Rothwell S,Day PJ,McHugh NJ,Betteridge ZE,Cooper RG,Ollier WE,Chinoy H,Lamb JA,Myositis Genetics Consortium (MYOGEN).

更新日期：2016-07-07 00:00:00

abstract：INTRODUCTION:High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The ai...

journal_title：Arthritis research & therapy

authors： Svensson B,Hafström I,Erlandsson MC,Forslind K,Bokarewa MI

更新日期：2014-01-16 00:00:00

abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

journal_title：Arthritis research & therapy

authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in gout medication use. METHODS:We analyzed annual visit and drug utilization data from national sa...

journal_title：Arthritis research & therapy

authors： Krishnan E,Chen L

更新日期：2013-11-06 00:00:00

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Desp...

journal_title：Arthritis research & therapy

authors： Lee HR,Yoo SJ,Kim J,Yoo IS,Park CK,Kang SW

更新日期：2020-05-15 00:00:00