The autoimmune tautology.

abstract：INTRODUCTION:The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have been proven to play an important role in the ...

journal_title：Arthritis research & therapy

authors： Kawanishi Y,Nakasa T,Shoji T,Hamanishi M,Shimizu R,Kamei N,Usman MA,Ochi M

更新日期：2014-11-28 00:00:00

abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

journal_title：Arthritis research & therapy

authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are ...

journal_title：Arthritis research & therapy

authors： Nakagawa J,Koyama Y,Kawakami A,Ueki Y,Tsukamoto H,Horiuchi T,Nagano S,Uchino A,Ota T,Akahoshi M,Akashi K

更新日期：2017-08-11 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. METHODS:Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1...

journal_title：Arthritis research & therapy

authors： Yamada K,Yamamoto M,Saeki T,Mizushima I,Matsui S,Fujisawa Y,Hara S,Takahashi H,Nomura H,Kawa S,Kawano M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune responses to it in SLE, we investigated whether an HSP90 DNA vacc...

journal_title：Arthritis research & therapy

authors： Liu A,Shi FD,Cohen IR,Castaldo G,Matarese G,Quintana FJ,La Cava A

更新日期：2020-06-22 00:00:00

abstract：:TNF inhibitors are currently considered both effective and cost-effective in patients with active rheumatoid arthritis (RA), particularly in patients who have not responded fully to methotrexate. There is substantial doubt about the cost-effectiveness of TNF inhibitors as initial treatment for active RA. New data from...

journal_title：Arthritis research & therapy

authors： Scott DL,Kingsley G

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S) has been implicated in mineralization but has never been studied in OA. Here, we investigated t...

journal_title：Arthritis research & therapy

authors： Nasi S,Ehirchiou D,Chatzianastasiou A,Nagahara N,Papapetropoulos A,Bertrand J,Cirino G,So A,Busso N

更新日期：2020-03-17 00:00:00

abstract：INTRODUCTION:The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS:The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of...

journal_title：Arthritis research & therapy

authors： Franklin J,Ingvarsson T,Englund M,Lohmander S

更新日期：2010-01-01 00:00:00

abstract：:The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been m...

journal_title：Arthritis research & therapy

authors： Lachmann HJ,Hawkins PN

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

journal_title：Arthritis research & therapy

authors： Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated in representing a novel therapy for rheumatoid arthritis. However, evidence of anti-inflammatory effects of VNS in humans is very scarc...

journal_title：Arthritis research & therapy

authors： Kox M,van Eijk LT,Verhaak T,Frenzel T,Kiers HD,Gerretsen J,van der Hoeven JG,Kornet L,Scheiner A,Pickkers P

更新日期：2015-06-07 00:00:00

abstract：:Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular e...

journal_title：Arthritis research & therapy

authors： Nurmohamed MT

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are involved in IIM, and the functional relationship between autoantib...

journal_title：Arthritis research & therapy

authors： Parkes JE,Rothwell S,Day PJ,McHugh NJ,Betteridge ZE,Cooper RG,Ollier WE,Chinoy H,Lamb JA,Myositis Genetics Consortium (MYOGEN).

更新日期：2016-07-07 00:00:00

abstract：:There has been a therapeutic revolution in rheumatology over the past 15 years, characterised by a move away from oral immuno-suppressive drugs toward parenteral targeted biological therapies. The potency and relative safety of the newer agents has facilitated a more aggressive approach to treatment, with many more pa...

journal_title：Arthritis research & therapy

authors： Isaacs JD

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we studied in detail the Flt3L/CD135 axis in RA patients. METHODS:The levels of Flt...

journal_title：Arthritis research & therapy

authors： Ramos MI,Perez SG,Aarrass S,Helder B,Broekstra P,Gerlag DM,Reedquist KA,Tak PP,Lebre MC

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) in...

journal_title：Arthritis research & therapy

authors： He S,Liu X,Lin Z,Liu Y,Gu L,Zhou H,Tang W,Zuo J

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

journal_title：Arthritis research & therapy

authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

更新日期：2019-12-16 00:00:00

abstract：OBJECTIVES:Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition with anakinra, an IL-1 receptor antagonist, improves clinical symptoms and inflammatory markers. Subc...

journal_title：Arthritis research & therapy

authors： Kuemmerle-Deschner JB,Wittkowski H,Tyrrell PN,Koetter I,Lohse P,Ummenhofer K,Reess F,Hansmann S,Koitschev A,Deuter C,Bialkowski A,Foell D,Benseler SM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) plays a pathogenic role in several rheumatic diseases including spondyloarthritis and, paradoxically, has been described to both promote and protect from bone formation. We therefore examined the effects of IL-17A on osteoblast differentiation in vitro and on periosteal bone formatio...

journal_title：Arthritis research & therapy

authors： Shaw AT,Maeda Y,Gravallese EM

更新日期：2016-05-10 00:00:00

abstract：INTRODUCTION:Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS:RA patie...

journal_title：Arthritis research & therapy

authors： Mulleman D,Méric JC,Paintaud G,Ducourau E,Magdelaine-Beuzelin C,Valat JP,Goupille P,Centre National de la Recherche Scientifique UMR 6239 GICC.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targeting the 16S rRNA gene in patients with reactive and other forms of arthritis and to screen for th...

journal_title：Arthritis research & therapy

authors： Siala M,Gdoura R,Fourati H,Rihl M,Jaulhac B,Younes M,Sibilia J,Baklouti S,Bargaoui N,Sellami S,Sghir A,Hammami A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA). METHODS:A self-reported questionnaire containing 12 items potentially relevant to PD and dentists' semiquantitative assessment of PD (no/mild/modera...

journal_title：Arthritis research & therapy

authors： Callhoff J,Dietrich T,Chubrieva M,Klotsche J,Zink A

更新日期：2019-08-29 00:00:00

abstract：INTRODUCTION:There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant anim...

journal_title：Arthritis research & therapy

authors： Vierboom MP,Breedveld E,Kondova I,'t Hart BA

更新日期：2010-01-01 00:00:00

abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

journal_title：Arthritis research & therapy

authors： MacMullan PA,McCarthy GM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

journal_title：Arthritis research & therapy

authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

更新日期：2012-01-08 00:00:00