Abstract:
INTRODUCTION:Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated in representing a novel therapy for rheumatoid arthritis. However, evidence of anti-inflammatory effects of VNS in humans is very scarce. Transvenous VNS (tVNS) is a newly developed and less invasive method to stimulate the vagus nerve. In the present study, we determined whether tVNS is a feasible and safe procedure and investigated its putative anti-inflammatory effects during experimental human endotoxemia. METHODS:We performed a randomized double-blind sham-controlled study in healthy male volunteers. A stimulation catheter was inserted in the left internal jugular vein at spinal level C5-C7, adjacent to the vagus nerve. In the tVNS group (n = 10), stimulation was continuously performed for 30 minutes (0-10 V, 1 ms, 20 Hz), starting 10 minutes before intravenous administration of 2 ng kg(-1) Escherichia coli lipopolysaccharide (LPS). Sham-instrumented subjects (n = 10) received no electrical stimulation. RESULTS:No serious adverse events occurred throughout the study. In the tVNS group, stimulation of the vagus nerve was achieved as indicated by laryngeal vibration. Endotoxemia resulted in fever, flu-like symptoms, and hemodynamic changes that were unaffected by tVNS. Furthermore, plasma levels of inflammatory cytokines increased sharply during endotoxemia, but responses were similar between groups. Finally, cytokine production by leukocytes stimulated with LPS ex vivo, as well as neutrophil phagocytosis capacity, were not influenced by tVNS. CONCLUSIONS:tVNS is feasible and safe, but does not modulate the innate immune response in humans in vivo during experimental human endotoxemia. TRIAL REGISTRATION:Clinicaltrials.gov NCT01944228. Registered 12 September 2013.
journal_name
Arthritis Res Therjournal_title
Arthritis research & therapyauthors
Kox M,van Eijk LT,Verhaak T,Frenzel T,Kiers HD,Gerretsen J,van der Hoeven JG,Kornet L,Scheiner A,Pickkers Pdoi
10.1186/s13075-015-0667-5subject
Has Abstractpub_date
2015-06-07 00:00:00pages
150eissn
1478-6354issn
1478-6362pii
10.1186/s13075-015-0667-5journal_volume
17pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To investigate dependencies in more detail, we compared IgG hypogalactosylation between patients with RA,...
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pub_type: 社论
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journal_title:Arthritis research & therapy
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pub_type: 临床试验,杂志文章
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pub_type: 评论,社论
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pub_type: 评论,社论
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journal_title:Arthritis research & therapy
pub_type: 杂志文章,随机对照试验
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pub_type: 评论,社论
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pub_type: 杂志文章,评审
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pub_type: 已发布勘误
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pub_type: 杂志文章
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