Progression of coronary artery atherosclerosis in rheumatoid arthritis: comparison with participants from the Multi-Ethnic Study of Atherosclerosis.

abstract：BACKGROUND:Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. Cross-re...

journal_title：Arthritis research & therapy

authors： Deng H,Wang C,Chang DY,Hu N,Chen M,Zhao MH

更新日期：2017-06-06 00:00:00

abstract：INTRODUCTION:The foot is largely overlooked in calls for better characterisation of clinical phenotypes in osteoarthritis (OA). Yet the midfoot complex in particular has the potential to provide important insights into OA pathogenesis given its central role in lower limb load transmission and alignment. Its recent incl...

journal_title：Arthritis research & therapy

authors： Thomas MJ,Peat G,Rathod T,Marshall M,Moore A,Menz HB,Roddy E

更新日期：2015-07-13 00:00:00

abstract：BACKGROUND:In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to ...

journal_title：Arthritis research & therapy

authors： Esposito J,Brown Z,Stevens W,Sahhar J,Rabusa C,Zochling J,Roddy J,Walker J,Proudman SM,Nikpour M

更新日期：2016-10-22 00:00:00

abstract：INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

journal_title：Arthritis research & therapy

authors： Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

更新日期：2015-11-13 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a me...

journal_title：Arthritis research & therapy

authors： Corallo C,Cutolo M,Kahaleh B,Pecetti G,Montella A,Chirico C,Soldano S,Nuti R,Giordano N

更新日期：2016-10-06 00:00:00

abstract：:A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 responses in 54%, 26% and 8% of patients, respectively. A placebo group was not included. Thirty-seven per cent of...

journal_title：Arthritis research & therapy

authors： Walker UA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) plays a pathogenic role in several rheumatic diseases including spondyloarthritis and, paradoxically, has been described to both promote and protect from bone formation. We therefore examined the effects of IL-17A on osteoblast differentiation in vitro and on periosteal bone formatio...

journal_title：Arthritis research & therapy

authors： Shaw AT,Maeda Y,Gravallese EM

更新日期：2016-05-10 00:00:00

abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

journal_title：Arthritis research & therapy

authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

更新日期：2003-01-01 00:00:00

abstract：:The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40/CD40 ligand (CD40/CD40L) receptor-ligand dyad. The therapeutic efficacy of a synthet...

journal_title：Arthritis research & therapy

authors： Hückel M,Schurigt U,Wagner AH,Stöckigt R,Petrow PK,Thoss K,Gajda M,Henzgen S,Hecker M,Bräuer R

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The human monoclonal antibody adalimumab is known to induce an anti-globulin response in some adalimumab-treated patients. Antibodies against adalimumab (AAA) are associated with non-response to treatment. Immunoglobulins, such as adalimumab, carry allotypes which represent slight differences in the amino ...

journal_title：Arthritis research & therapy

authors： Bartelds GM,de Groot E,Nurmohamed MT,Hart MH,van Eede PH,Wijbrandts CA,Crusius JB,Dijkmans BA,Tak PP,Aarden L,Wolbink GJ

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). METHODS:Serum from patients with RA and osteoarthritis (OA), and healthy controls, and synov...

journal_title：Arthritis research & therapy

authors： Min HK,Won JY,Kim BM,Lee KA,Lee SJ,Lee SH,Kim HR,Kim KW

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor in RA progression, which promotes fibroblast-like synoviocyte (FLS) proliferation, pannus formation, ...

journal_title：Arthritis research & therapy

authors： Sun W,Ma J,Zhao H,Xiao C,Zhong H,Ling H,Xie Z,Tian Q,Chen H,Zhang T,Chen M,Jin S,Wang J

更新日期：2020-03-27 00:00:00

abstract：INTRODUCTION:To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in huma...

journal_title：Arthritis research & therapy

authors： Steinert AF,Weissenberger M,Kunz M,Gilbert F,Ghivizzani SC,Göbel S,Jakob F,Nöth U,Rudert M

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of phosphorylated signal transd...

journal_title：Arthritis research & therapy

authors： McInnes IB,Byers NL,Higgs RE,Lee J,Macias WL,Na S,Ortmann RA,Rocha G,Rooney TP,Wehrman T,Zhang X,Zuckerman SH,Taylor PC

更新日期：2019-08-02 00:00:00

abstract：INTRODUCTION:Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim of this study was to detect the levels of ...

journal_title：Arthritis research & therapy

authors： Wu Y,Zhang F,Ma J,Zhang X,Wu L,Qu B,Xia S,Chen S,Tang Y,Shen N

更新日期：2015-05-21 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

journal_title：Arthritis research & therapy

authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

更新日期：2012-02-15 00:00:00

abstract：:The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990...

journal_title：Arthritis research & therapy

authors： Boyce BF,Xing L

更新日期：2007-01-01 00:00:00

abstract：:Osteoporosis results from a loss of bone mass and bone structure such that the bone becomes weak and fractures with very little trauma. Until recently, the approved osteoporosis therapies prevented more bone loss by altering osteoclast activity and lifespan. Recently, attention has turned away from osteoclast inhibiti...

journal_title：Arthritis research & therapy

authors： Lane NE,Kelman A

更新日期：2003-01-01 00:00:00

abstract：:It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of th...

journal_title：Arthritis research & therapy

authors： Sherlock JP,Filer AD,Isaacs JD,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

journal_title：Arthritis research & therapy

authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

更新日期：2012-01-08 00:00:00

abstract：:Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have p...

journal_title：Arthritis research & therapy

authors： Villanueva J,Lee S,Giannini EH,Graham TB,Passo MH,Filipovich A,Grom AA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have be...

journal_title：Arthritis research & therapy

authors： Roubille C,Raynauld JP,Abram F,Paiement P,Dorais M,Delorme P,Bessette L,Beaulieu AD,Martel-Pelletier J,Pelletier JP

更新日期：2014-12-14 00:00:00

abstract：:Anti-Sa antibodies are detected in the serum of 20-47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed th...

journal_title：Arthritis research & therapy

authors： El-Gabalawy HS,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the effects of risedronate (Ris) in the modulation of bone formation in rats with glucocorticoid (GC)-induced osteoporosis by histomorphometric, immunohistochemical and gene expression analyses. METHODS:We analyzed structure, turnover and microarchitecture, cycloo...

journal_title：Arthritis research & therapy

authors： Valenti MT,Giannini S,Donatelli L,Zanatta M,Bertoldo F,Sella S,Vilei MT,Ossi E,Realdi G,Lo Cascio V,Dalle Carbonare L

更新日期：2010-01-01 00:00:00

abstract：:Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular e...

journal_title：Arthritis research & therapy

authors： Nurmohamed MT

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Costochondral cells may be isolated with minimal donor site morbidity and are unaffected by pathologies of the diarthrodial joints. Identification of optimal exogenous stimuli will allow abundant and robust hyaline articular cartilage to be formed from this cell source. METHODS:In a three factor, two leve...

journal_title：Arthritis research & therapy

authors： Murphy MK,DuRaine GD,Reddi A,Hu JC,Athanasiou KA

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations in the T lymphocyte compartment and dysregulated cytokine production are key features of SLE pathogenesis and disease progression. Recently...

journal_title：Arthritis research & therapy

authors： Puwipirom H,Hirankarn N,Sodsai P,Avihingsanon Y,Wongpiyabovorn J,Palaga T

更新日期：2010-01-01 00:00:00