Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway.

abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these patients, particularly with the widespread use of immunomodulating therapies, including biologic disease-modifying antirheumatic drugs (DMARDs). We...

journal_title：Arthritis research & therapy

authors： Simon TA,Thompson A,Gandhi KK,Hochberg MC,Suissa S

更新日期：2015-08-15 00:00:00

abstract：:Inhibition of NF-kappaB is known to be effective in reducing both inflammation and bone destruction in animal models of arthritis. Our previous study demonstrated that a small cell-permeable NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses expression of proinflammatory cytokines and ameliorates ...

journal_title：Arthritis research & therapy

authors： Kubota T,Hoshino M,Aoki K,Ohya K,Komano Y,Nanki T,Miyasaka N,Umezawa K

更新日期：2007-01-01 00:00:00

abstract：:We analyzed the clinical response and the time to relapse after discontinuation of continuous long-term infliximab therapy in patients with ankylosing spondylitis (AS). After 3 years of infliximab therapy, all AS patients (n = 42) discontinued treatment (time point (TP)1) and were visited regularly for 1 year in order...

journal_title：Arthritis research & therapy

authors： Baraliakos X,Listing J,Brandt J,Zink A,Alten R,Burmester G,Gromnica-Ihle E,Kellner H,Schneider M,Sörensen H,Zeidler H,Rudwaleit M,Sieper J,Braun J

更新日期：2005-01-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondr...

journal_title：Arthritis research & therapy

authors： Brochhausen C,Neuland P,Kirkpatrick CJ,Nüsing RM,Klaus G

更新日期：2006-01-01 00:00:00

abstract：:Following publication of the original article [1], the authors reported a typesetting error. ...

journal_title：Arthritis research & therapy

authors： Orsolini G,Adami G,Rossini M,Fassio A,Giollo A,Caimmi C,Idolazzi L,Gatti D,Viapiana O

更新日期：2018-11-05 00:00:00

abstract：:Dysregulated psychophysiological responses have been observed in patients with fibromyalgia syndrome (FMS), although the results are inconsistent. Surface electromyographic (EMG), systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels (SCLs) were continuously recorded at baseline, and duri...

journal_title：Arthritis research & therapy

authors： Thieme K,Turk DC

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significantly decreased after treatment. However, little is known about the nature of this cell entity. ...

journal_title：Arthritis research & therapy

authors： Yang HX,Zhang W,Zhao LD,Li Y,Zhang FC,Tang FL,He W,Zhang X

更新日期：2009-01-01 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different BALB/c colonies develop proteoglycan-induced arthritis and proteoglycan-induced spondylitis in res...

journal_title：Arthritis research & therapy

authors： Farkas B,Boldizsar F,Tarjanyi O,Laszlo A,Lin SM,Hutas G,Tryniszewska B,Mangold A,Nagyeri G,Rosenzweig HL,Finnegan A,Mikecz K,Glant TT

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4+ T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the...

journal_title：Arthritis research & therapy

authors： Kuuliala K,Kuuliala A,Koivuniemi R,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2017-04-11 00:00:00

abstract：INTRODUCTION:Since current treatment options for patients suffering from active rheumatoid arthritis (RA) remain inadequate, especially for those unresponsive to disease-modifying antirheumatic drugs (DMARDs), new and improved medication is needed. This study evaluates the safety and efficacy of masitinib (AB1010), a p...

journal_title：Arthritis research & therapy

authors： Tebib J,Mariette X,Bourgeois P,Flipo RM,Gaudin P,Le Loët X,Gineste P,Guy L,Mansfield CD,Moussy A,Dubreuil P,Hermine O,Sibilia J

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:We sought to assess vascularity in wrist tenosynovitis by using power Doppler ultrasound (PDUS) and to compare detection of intra- and peritendinous vascularity with that of contrast-enhanced grey-scale ultrasound (CEUS). METHODS:Twenty-six tendons of 24 patients (nine men, 15 women; mean age ± SD, 54.4 ±...

journal_title：Arthritis research & therapy

authors： Klauser AS,Franz M,Arora R,Feuchtner GM,Gruber J,Schirmer M,Jaschke WR,Gabl MF

更新日期：2010-01-01 00:00:00

abstract：:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction distur...

journal_title：Arthritis research & therapy

authors： Fritsch C,Hoebeke J,Dali H,Ricchiuti V,Isenberg DA,Meyer O,Muller S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. METHODS:Thirty-one female subjects with OA ...

journal_title：Arthritis research & therapy

authors： Helmark IC,Mikkelsen UR,Børglum J,Rothe A,Petersen MC,Andersen O,Langberg H,Kjaer M

更新日期：2010-01-01 00:00:00

abstract：:Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsi...

journal_title：Arthritis research & therapy

authors： Jain V,Gordon C

更新日期：2011-02-25 00:00:00

abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

journal_title：Arthritis research & therapy

authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

更新日期：2003-01-01 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：:Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic factors, particularly the presence of HLA-B27, are major contributors to the susceptibility for AS. Despite s...

journal_title：Arthritis research & therapy

authors： Peloso PM,Braun J

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE ...

journal_title：Arthritis research & therapy

authors： Meyer PW,Hodkinson B,Ally M,Musenge E,Wadee AA,Fickl H,Tikly M,Anderson R

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with partic...

journal_title：Arthritis research & therapy

authors： Zhang Z,Ding Y,Li W,Song B,Yang R

更新日期：2013-10-29 00:00:00

abstract：INTRODUCTION:Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypo...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Ruyssen-Witrand A,Huizinga TW,Cantagrel A,Berenbaum F,van der Helm-van Mil AH

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expres...

journal_title：Arthritis research & therapy

authors： Alivernini S,Bruno D,Tolusso B,Bui L,Petricca L,Gigante MR,Birra D,Fedele AL,Peluso G,Federico F,Ferraccioli G,Gremese E

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

journal_title：Arthritis research & therapy

authors： Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

更新日期：2020-12-10 00:00:00

abstract：BACKGROUND:It is currently impossible to predict the prognosis of patients with juvenile dermatomyositis (JDM). The aim of this study was to find clinical features most strongly associated with outcome variables in JDM as a first step towards tailor-made treatment. METHODS:In a large, prospectively followed, multicent...

journal_title：Arthritis research & therapy

authors： van Dijkhuizen EHP,De Iorio M,Wedderburn LR,Deakin CT,JDRG.

更新日期：2018-08-15 00:00:00

abstract：INTRODUCTION:Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced arthritis. This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific ...

journal_title：Arthritis research & therapy

authors： Vadasz Z,Haj T,Halasz K,Rosner I,Slobodin G,Attias D,Kessel A,Kessler O,Neufeld G,Toubi E

更新日期：2012-06-14 00:00:00

abstract：INTRODUCTION:Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor κ B Ligand) to RANK results in the activation of TRAF6 (tumor necros...

journal_title：Arthritis research & therapy

authors： Knevel R,de Rooy DP,Saxne T,Lindqvist E,Leijsma MK,Daha NA,Koeleman BP,Tsonaka R,Houwing-Duistermaat JJ,Schonkeren JJ,Toes RE,Huizinga TW,Brouwer E,Wilson AG,van der Helm-van Mil AH

更新日期：2014-05-07 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might...

journal_title：Arthritis research & therapy

authors： Berthelot JM,Le Goff B,Maugars Y

更新日期：2019-11-13 00:00:00