Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis?

abstract：BACKGROUND:Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. METHODS:Patients in PREDICT were randomiz...

journal_title：Arthritis research & therapy

authors： Curtis JR,Herrem C,Ndlovu 'N,O'Brien C,Yazici Y

更新日期：2017-09-29 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor erythroid 2-related factor 2 (Nrf2) as a major requirement for limiting cartilage destruction. NF-...

journal_title：Arthritis research & therapy

authors： Fragoulis A,Laufs J,Müller S,Soppa U,Siegl S,Reiss LK,Tohidnezhad M,Rosen C,Tenbrock K,Varoga D,Lippross S,Pufe T,Wruck CJ

更新日期：2012-10-27 00:00:00

abstract：INTRODUCTION:Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate wh...

journal_title：Arthritis research & therapy

authors： Lee SY,Kwok SK,Son HJ,Ryu JG,Kim EK,Oh HJ,Cho ML,Ju JH,Park SH,Kim HY

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model. METHODS:Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg oral spironolactone or vehicle. Proteinuria...

journal_title：Arthritis research & therapy

authors： Monrad SU,Killen PD,Anderson MR,Bradke A,Kaplan MJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

journal_title：Arthritis research & therapy

authors： Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

更新日期：2012-04-30 00:00:00

abstract：INTRODUCTION:This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort. METHODS:The magnitude of association for each genotype was assessed in 1,046 RA subjects...

journal_title：Arthritis research & therapy

authors： Morgan AW,Robinson JI,Conaghan PG,Martin SG,Hensor EM,Morgan MD,Steiner L,Erlich HA,Gooi HC,Barton A,Worthington J,Emery P,UKRAG Consortium.,YEAR Consortium.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of the present study was to evaluate the relationship between baseline CXCL4 level and extent of ILD i...

journal_title：Arthritis research & therapy

authors： Volkmann ER,Tashkin DP,Roth MD,Clements PJ,Khanna D,Furst DE,Mayes M,Charles J,Tseng CH,Elashoff RM,Assassi S

更新日期：2016-12-30 00:00:00

abstract：INTRODUCTION:Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is available for...

journal_title：Arthritis research & therapy

authors： Mahmood Z,Muhammad K,Schmalzing M,Roll P,Dörner T,Tony HP

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype. METHODS:A total of 116 RA patients and 31 ag...

journal_title：Arthritis research & therapy

authors： Fujita Y,Asano T,Matsuoka N,Temmoku J,Sato S,Matsumoto H,Furuya MY,Suzuki E,Watanabe H,Kawakami A,Migita K

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

journal_title：Arthritis research & therapy

authors： Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS:A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography...

journal_title：Arthritis research & therapy

authors： Guillén-Del-Castillo A,Simeón-Aznar CP,Callejas-Moraga EL,Tolosa-Vilella C,Alonso-Vila S,Fonollosa-Pla V,Selva-O'Callaghan A

更新日期：2018-12-19 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：INTRODUCTION:A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little information as to the gene activity changes occurring during the disease process. Transcriptional profiling generates a 'snapshot' of the sampled cells...

journal_title：Arthritis research & therapy

authors： Pimentel-Santos FM,Ligeiro D,Matos M,Mourão AF,Costa J,Santos H,Barcelos A,Godinho F,Pinto P,Cruz M,Fonseca JE,Guedes-Pinto H,Branco JC,Brown MA,Thomas GP

更新日期：2011-04-07 00:00:00

abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

journal_title：Arthritis research & therapy

authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

更新日期：2013-01-01 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

journal_title：Arthritis research & therapy

authors： Krane SM

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

journal_title：Arthritis research & therapy

authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) in...

journal_title：Arthritis research & therapy

authors： He S,Liu X,Lin Z,Liu Y,Gu L,Zhou H,Tang W,Zuo J

更新日期：2019-01-29 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：INTRODUCTION:Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced arthritis. This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific ...

journal_title：Arthritis research & therapy

authors： Vadasz Z,Haj T,Halasz K,Rosner I,Slobodin G,Attias D,Kessel A,Kessler O,Neufeld G,Toubi E

更新日期：2012-06-14 00:00:00

abstract：INTRODUCTION:Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume measurement in clinically stable patients with tophaceous gout. METHODS:Seventy-three patients wi...

journal_title：Arthritis research & therapy

authors： Rajan A,Aati O,Kalluru R,Gamble GD,Horne A,Doyle AJ,McQueen FM,Dalbeth N

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, both in vivo and in vitro. However, few studies have shed light on degenerative nucleus pulposus cells...

journal_title：Arthritis research & therapy

authors： Han Z,Wang J,Gao L,Wang Q,Wu J

更新日期：2018-08-16 00:00:00

abstract：:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contributi...

journal_title：Arthritis research & therapy

authors： Youinou P,Pers JO

更新日期：2011-07-06 00:00:00

abstract：BACKGROUND:Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), suggest a disease activity (DA) phase in systemic sclerosis (SSc). In a previous paper, we showed that...

journal_title：Arthritis research & therapy

authors： Andracco R,Irace R,Zaccara E,Vettori S,Maglione W,Riccardi A,Pignataro F,Ferrara R,Sambataro D,Sambataro G,Vitali C,Valentini G,Del Papa N

更新日期：2017-06-13 00:00:00

abstract：INTRODUCTION:The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS:The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of...

journal_title：Arthritis research & therapy

authors： Franklin J,Ingvarsson T,Englund M,Lohmander S

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort. METHODS:All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Sp...

journal_title：Arthritis research & therapy

authors： Narváez J,Borrell H,Sánchez-Alonso F,Rúa-Figueroa I,López-Longo FJ,Galindo-Izquierdo M,Calvo-Alén J,Fernández-Nebro A,Olivé A,Andreu JL,Martínez-Taboada V,Nolla JM,Pego-Reigosa JM,RELESSER Study Group.

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

journal_title：Arthritis research & therapy

authors： Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement. METHOD:We searched for available observational studies up to January 2015 in Medline and Embase accordin...

journal_title：Arthritis research & therapy

authors： Bastick AN,Runhaar J,Belo JN,Bierma-Zeinstra SM

更新日期：2015-06-08 00:00:00

abstract：:With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a cen...

journal_title：Arthritis research & therapy

authors： Walmsley SR,Chilvers ER,Whyte MK

更新日期：2009-01-01 00:00:00