High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route.

abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

journal_title：Arthritis research & therapy

authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. METHODS:Patients in PREDICT were randomiz...

journal_title：Arthritis research & therapy

authors： Curtis JR,Herrem C,Ndlovu 'N,O'Brien C,Yazici Y

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction distur...

journal_title：Arthritis research & therapy

authors： Fritsch C,Hoebeke J,Dali H,Ricchiuti V,Isenberg DA,Meyer O,Muller S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune responses to it in SLE, we investigated whether an HSP90 DNA vacc...

journal_title：Arthritis research & therapy

authors： Liu A,Shi FD,Cohen IR,Castaldo G,Matarese G,Quintana FJ,La Cava A

更新日期：2020-06-22 00:00:00

abstract：INTRODUCTION:Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose-derived stromal cell (ASC) injection in the healing process on cartilage, synovial membrane and menisci in an experimental rabbit model. ME...

journal_title：Arthritis research & therapy

authors： Desando G,Cavallo C,Sartoni F,Martini L,Parrilli A,Veronesi F,Fini M,Giardino R,Facchini A,Grigolo B

更新日期：2013-01-29 00:00:00

abstract：INTRODUCTION:The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). METHODS:Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy controls (HCs) were stimulated in vitro, and the frequencies of IL-21 p...

journal_title：Arthritis research & therapy

authors： Abdulahad WH,Lepse N,Stegeman CA,Huitema MG,Doornbos-van der Meer B,Tadema H,Rutgers A,Limburg PC,Kallenberg CG,Heeringa P

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

journal_title：Arthritis research & therapy

authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

更新日期：2012-08-17 00:00:00

abstract：:The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes. The cells were isolated from human articular cartilage obtained at surgery and were cultured in the absence or presence of ET-1 with or without inhibi...

journal_title：Arthritis research & therapy

authors： Manacu CA,Martel-Pelletier J,Roy-Beaudry M,Pelletier JP,Fernandes JC,Shipkolye FS,Mitrovic DR,Moldovan F

更新日期：2005-01-01 00:00:00

abstract：:B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of c...

journal_title：Arthritis research & therapy

authors： Dörner T,Jacobi AM,Lipsky PE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in patients with psoriatic arthritis (PsA) and compare these findings with other radiological scoring ...

journal_title：Arthritis research & therapy

authors： Pfeil A,Krojniak L,Renz DM,Reinhardt L,Franz M,Oelzner P,Wolf G,Böttcher J

更新日期：2016-10-25 00:00:00

abstract：INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

journal_title：Arthritis research & therapy

authors： Rutgers M,Saris DB,Dhert WJ,Creemers LB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the role of hand bone mineral density (BMD) loss analyzed with digital X-ray radiogrammetry (DXR) in early rheumatoid arthritis (RA) as a predictor for progression of joint damage. METHODS:In 379 patients with early RA, baseline and one-year hand BMD was measured w...

journal_title：Arthritis research & therapy

authors： Forslind K,Kälvesten J,Hafström I,Svensson B,BARFOT Study Group.

更新日期：2012-10-15 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype. METHODS:A total of 116 RA patients and 31 ag...

journal_title：Arthritis research & therapy

authors： Fujita Y,Asano T,Matsuoka N,Temmoku J,Sato S,Matsumoto H,Furuya MY,Suzuki E,Watanabe H,Kawakami A,Migita K

更新日期：2020-04-15 00:00:00

abstract：:Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET)...

journal_title：Arthritis research & therapy

authors： Yamashita H,Kubota K,Mimori A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might...

journal_title：Arthritis research & therapy

authors： Berthelot JM,Le Goff B,Maugars Y

更新日期：2019-11-13 00:00:00

abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

journal_title：Arthritis research & therapy

authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Desp...

journal_title：Arthritis research & therapy

authors： Lee HR,Yoo SJ,Kim J,Yoo IS,Park CK,Kang SW

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore the relationship between multisite pain and falls and to quantify associated risks. METHODS:Bibliog...

journal_title：Arthritis research & therapy

authors： Welsh VK,Clarson LE,Mallen CD,McBeth J

更新日期：2019-02-22 00:00:00

abstract：INTRODUCTION:In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atherosclerosis, in a series of Spanish patients with rheumatoid arthritis (RA) without clinically evident ca...

journal_title：Arthritis research & therapy

authors： González-Juanatey C,Llorca J,González-Gay MA

更新日期：2011-06-22 00:00:00

abstract：INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

journal_title：Arthritis research & therapy

authors： Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

更新日期：2011-02-03 00:00:00

abstract：INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

journal_title：Arthritis research & therapy

authors： Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Abneg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expres...

journal_title：Arthritis research & therapy

authors： Alivernini S,Bruno D,Tolusso B,Bui L,Petricca L,Gigante MR,Birra D,Fedele AL,Peluso G,Federico F,Ferraccioli G,Gremese E

更新日期：2019-05-09 00:00:00

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chro...

journal_title：Arthritis research & therapy

authors： Barsalou J,Bradley TJ,Silverman ED

更新日期：2013-01-01 00:00:00

abstract：:It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of th...

journal_title：Arthritis research & therapy

authors： Sherlock JP,Filer AD,Isaacs JD,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of mycophenolate sodium (MPS) in patients with primary Sjögren syndrome (pSS) refractory to other immunosuppressive agents. Eleven patients with pSS were treated with MPS up to 1,440 mg daily for an observation period of 6 months in this single-center, open...

journal_title：Arthritis research & therapy

authors： Willeke P,Schlüter B,Becker H,Schotte H,Domschke W,Gaubitz M

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:IL-10 is a very important anti-inflammatory cytokine. However, the role of this cytokine in T cells in the pathogenesis of collagen-induced arthritis is unclear. The purpose of this study was to define the role of IL-10 signaling in T cells in the pathogenesis of collagen-induced arthritis. METHODS:IL-10 ...

journal_title：Arthritis research & therapy

authors： Tao J,Kamanaka M,Hao J,Hao Z,Jiang X,Craft JE,Flavell RA,Wu Z,Hong Z,Zhao L,Yin Z

更新日期：2011-01-01 00:00:00

abstract：:The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA) remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently, murine models of arthritis are induced by imm...

journal_title：Arthritis research & therapy

authors： Kamradt T,Schubert D

更新日期：2005-01-01 00:00:00