当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > Mycophenolate sodium treatment in patients with primary Sjögren syndrome: a pilot trial.

Mycophenolate sodium treatment in patients with primary Sjögren syndrome: a pilot trial.

Abstract：

:The aim of this study was to evaluate the efficacy and safety of mycophenolate sodium (MPS) in patients with primary Sjögren syndrome (pSS) refractory to other immunosuppressive agents. Eleven patients with pSS were treated with MPS up to 1,440 mg daily for an observation period of 6 months in this single-center, open-label pilot trial. At baseline, after 3 months, and after 6 months, we examined the clinical status, including glandular function tests, as well as different laboratory parameters associated with pSS. In addition, subjective parameters were determined on the basis of different questionnaires. Treatment with MPS was well tolerated in 8 of 11 patients. Due to vertigo or gastrointestinal discomfort, two patients did not complete the trial. One patient developed pneumonia 2 weeks after treatment and was withdrawn. In the remaining patients, MPS treatment resulted in subjective improvement of ocular dryness on a visual analogue scale and a reduced demand for artificial tear supplementations. However, no significant alterations of objective parameters for dryness of eyes and mouth were observed, although a substantial improvement of glandular functions occurred in two patients with short disease duration. In addition, treatment with MPS resulted in significant reduction of hypergammaglobulinemia and rheumatoid factors as well as an increase of complement levels and white blood cells. MPS promises to be an additional therapeutic option for patients with pSS, at least in those with shorter disease duration. Further investigations about the efficacy and safety of MPS in pSS have to be performed in larger numbers of patients.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Willeke P,Schlüter B,Becker H,Schotte H,Domschke W,Gaubitz M

doi

10.1186/ar2322

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

R115

issue

6

eissn

1478-6354

issn

1478-6362

pii

ar2322

journal_volume

9

pub_type

临床试验,杂志文章

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitinib.

    abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02324-7

    authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

    更新日期：2020-10-15 00:00:00

  • A Dose-response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine.

    abstract：INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0820-1

    authors： Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

    更新日期：2015-10-23 00:00:00

  • Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study.

    abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1242-z

    authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

    更新日期：2017-02-10 00:00:00

  • Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature.

    abstract：INTRODUCTION:Mutations in the NLRP3 gene are associated with the dominantly inherited cryopyrin-associated periodic syndrome (CAPS). The significance of the V198M variant is unclear; it has been reported in association with various CAPS phenotypes and as a variant of uncertain consequence. The aim of this study was to ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4171

    authors： Rowczenio DM,Trojer H,Russell T,Baginska A,Lane T,Stewart NM,Gillmore JD,Hawkins PN,Woo P,Mikoluc B,Lachmann HJ

    更新日期：2013-02-19 00:00:00

  • Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

    abstract：BACKGROUND:In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13 and ADAMTS-5. The activation of the hedgehog signalling pathway has been established in osteoarthritis and is thought to influence both of these proces...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0891-z

    authors： Thompson CL,Patel R,Kelly TA,Wann AK,Hung CT,Chapple JP,Knight MM

    更新日期：2015-12-24 00:00:00

  • Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis.

    abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1323-z

    authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

    更新日期：2017-05-31 00:00:00

  • Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis.

    abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar610

    authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

    更新日期：2003-01-01 00:00:00

  • Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proin

    abstract：INTRODUCTION:The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metal...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2844

    authors： Choi HM,Lee YA,Lee SH,Hong SJ,Hahm DH,Choi SY,Yang HI,Yoo MC,Kim KS

    更新日期：2009-01-01 00:00:00

  • Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

    abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2066-9

    authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

    更新日期：2019-12-16 00:00:00

  • Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and d...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3541

    authors： Eggleton P,Bremer E,Tarr JM,de Bruyn M,Helfrich W,Kendall A,Haigh RC,Viner NJ,Winyard PG

    更新日期：2011-01-01 00:00:00

  • Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus.

    abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-018-1561-8

    authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

    更新日期：2018-04-10 00:00:00

  • The new era of autoimmune disease research.

    abstract：:Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3335

    authors： Koike T

    更新日期：2011-05-31 00:00:00

  • Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis.

    abstract：INTRODUCTION:Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial fluid sampling offers the potential to examine local mechanisms and identify proteins expressed withi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0575-8

    authors： Clark KE,Lopez H,Abdi BA,Guerra SG,Shiwen X,Khan K,Etomi O,Martin GR,Abraham DJ,Denton CP,Stratton RJ

    更新日期：2015-03-23 00:00:00

  • Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis.

    abstract：INTRODUCTION:Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial cit...

    journal_title：Arthritis research & therapy

    pub_type： 临床试验,杂志文章

    doi：10.1186/ar3702

    authors： Makrygiannakis D,Revu S,Engström M,af Klint E,Nicholas AP,Pruijn GJ,Catrina AI

    更新日期：2012-01-27 00:00:00

  • Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.

    abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disea...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13075-018-1604-1

    authors： Julià A,López-Longo FJ,Pérez Venegas JJ,Bonàs-Guarch S,Olivé À,Andreu JL,Aguirre-Zamorano MÁ,Vela P,Nolla JM,de la Fuente JLM,Zea A,Pego-Reigosa JM,Freire M,Díez E,Rodríguez-Almaraz E,Carreira P,Blanco R,Taboada VM,Ló

    更新日期：2018-05-30 00:00:00

  • A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis.

    abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13075-019-1888-9

    authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

    更新日期：2019-04-11 00:00:00

  • Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study.

    abstract：INTRODUCTION:Cardiovascular disease (CVD) is the leading cause of death in patients with inflammatory polyarthritis (IP), especially in seropositive disease. In established rheumatoid arthritis (RA), insulin resistance (IR) is increased and associated with CVD. We investigated factors associated with IR in an inception...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3476

    authors： Mirjafari H,Farragher TM,Verstappen SM,Yates A,Bunn D,Marshall T,Lunt M,Symmons DP,Bruce IN

    更新日期：2011-01-01 00:00:00

  • Patients' preferences for osteoporosis drug treatment: a discrete-choice experiment.

    abstract：INTRODUCTION:The patient's perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication attributes, and to establish how patients trade between these attributes. METHODS:A discrete choic...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4465

    authors： Hiligsmann M,Dellaert BG,Dirksen CD,van der Weijden T,Goemaere S,Reginster JY,Watson V,Boonen A

    更新日期：2014-01-31 00:00:00

  • Fetal microchimerism in kidney biopsies of lupus nephritis patients may be associated with a beneficial effect.

    abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0615-4

    authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

    更新日期：2015-04-15 00:00:00

  • Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients.

    abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tightly orchestrated process dependent on several factors, including the balance between receptor acti...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究

    doi：10.1186/ar3500

    authors： Carmona-Fernandes D,Santos MJ,Perpétuo IP,Fonseca JE,Canhão H

    更新日期：2011-01-01 00:00:00

  • Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis.

    abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02279-9

    authors： Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

    更新日期：2020-08-12 00:00:00

  • Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study.

    abstract：INTRODUCTION:Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow therapeutic index and the considerable interpatient variability in clinical response, monitoring of a...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0814-z

    authors： Hawwa AF,AlBawab A,Rooney M,Wedderburn LR,Beresford MW,McElnay JC

    更新日期：2015-10-22 00:00:00

  • A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.

    abstract：:Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1802

    authors： Matsumoto I,Zhang H,Muraki Y,Hayashi T,Yasukochi T,Kori Y,Goto D,Ito S,Tsutsumi A,Sumida T

    更新日期：2005-01-01 00:00:00

  • IgG anti-hinge antibodies against IgG4 F(ab')2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes.

    abstract：BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02251-7

    authors： Ota T,Ota SI,Uchino A,Nagano S

    更新日期：2020-06-26 00:00:00

  • Reduced pro-inflammatory profile of γδT cells in pregnant patients with rheumatoid arthritis.

    abstract：BACKGROUND:During pregnancy, many patients with rheumatoid arthritis (RA) experience disease improvement, whereas patients with ankylosing spondylitis often suffer from persistent active disease. Here we investigated whether pregnancy-related changes in disease activity were associated with changes in the proportion an...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-0925-1

    authors： Tham M,Schlör GR,Yerly D,Mueller C,Surbek D,Villiger PM,Förger F

    更新日期：2016-01-22 00:00:00

  • Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers.

    abstract：:The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta₂ glycoprotein I (anti-β₂GPI) and lupus anticoagulant (LA) assays are not only ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar4549

    authors： Meroni PL,Chighizola CB,Rovelli F,Gerosa M

    更新日期：2014-01-01 00:00:00

  • Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis.

    abstract：INTRODUCTION:Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 + CXCR3-CCR6- (Tfh-Th2) and CXCR5 + CXCR3-CCR6+ (Tfh-Th17). Our objective was to study the B cell ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-014-0500-6

    authors： Arroyo-Villa I,Bautista-Caro MB,Balsa A,Aguado-Acín P,Bonilla-Hernán MG,Plasencia C,Villalba A,Nuño L,Puig-Kröger A,Martín-Mola E,Miranda-Carús ME

    更新日期：2014-12-05 00:00:00

  • Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases.

    abstract：INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3330

    authors： O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

    更新日期：2011-04-26 00:00:00

  • Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint.

    abstract：INTRODUCTION:The purpose of this study was the evaluation of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (IA) tumor necrosis factor (TNF)-α blockers in psoriatic arthritis (PsA). METHODS:Systemic and lo...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3090

    authors： Fiocco U,Sfriso P,Oliviero F,Roux-Lombard P,Scagliori E,Cozzi L,Lunardi F,Calabrese F,Vezzù M,Dainese S,Molena B,Scanu A,Nardacchione R,Rubaltelli L,Dayer JM,Punzi L

    更新日期：2010-01-01 00:00:00

  • Treatment persistence of biologics among patients with psoriatic arthritis.

    abstract：BACKGROUND:Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development. OBJECTIVE:To estimate the persistence of biologic agents prescribed to PsA patients in a real-life setting as well as fac...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-021-02417-x

    authors： Haddad A,Gazitt T,Feldhamer I,Feld J,Cohen AD,Lavi I,Tatour F,Bergman I,Zisman D

    更新日期：2021-01-29 00:00:00