Suppression of endothelial cell activity by inhibition of TNFα.

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a me...

journal_title：Arthritis research & therapy

authors： Corallo C,Cutolo M,Kahaleh B,Pecetti G,Montella A,Chirico C,Soldano S,Nuti R,Giordano N

更新日期：2016-10-06 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS:Arthroscopic assessment of articular cartilage damage was performed twice ...

journal_title：Arthritis research & therapy

authors： Sobue Y,Kojima T,Kurokouchi K,Takahashi S,Yoshida H,Poole R,Ishiguro N

更新日期：2017-12-06 00:00:00

abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

journal_title：Arthritis research & therapy

authors： MacMullan PA,McCarthy GM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：INTRODUCTION:NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflammasome. Although some ...

journal_title：Arthritis research & therapy

authors： Ito S,Hara Y,Kubota T

更新日期：2014-02-12 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：INTRODUCTION:Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by synovial macrophage activation. TA injections might influence macrophage activation and subsequently...

journal_title：Arthritis research & therapy

authors： Siebelt M,Korthagen N,Wei W,Groen H,Bastiaansen-Jenniskens Y,Müller C,Waarsing JH,de Jong M,Weinans H

更新日期：2015-12-05 00:00:00

abstract：INTRODUCTION:Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to develop a platform for clinical translation, we created a series of fully r...

journal_title：Arthritis research & therapy

authors： Jain A,Olsen HS,Vyzasatya R,Burch E,Sakoda Y,Mérigeon EY,Cai L,Lu C,Tan M,Tamada K,Schulze D,Block DS,Strome SE

更新日期：2012-08-20 00:00:00

abstract：INTRODUCTION:The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and consequently displays an ...

journal_title：Arthritis research & therapy

authors： Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J

更新日期：2010-01-01 00:00:00

abstract：:The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been m...

journal_title：Arthritis research & therapy

authors： Lachmann HJ,Hawkins PN

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional role in the pathogenesis in SLE. METHODS:Gene expression levels in peripheral blood cells (PBLs)...

journal_title：Arthritis research & therapy

authors： Feng X,Li R,Huang J,Zhang H,Zhu L,Hua B,Tsao BP,Sun L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Sulfur compounds isolated from garlic exert anti-inflammatory properties. We recently isolated thiacremonone, a novel sulfur compound from garlic. Here, we investigated the anti-inflammatory and arthritis properties of thiacremonone through inhibition of NF-kappaB since NF-kappaB is known to be a target mo...

journal_title：Arthritis research & therapy

authors： Ban JO,Oh JH,Kim TM,Kim DJ,Jeong HS,Han SB,Hong JT

更新日期：2009-01-01 00:00:00

abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

journal_title：Arthritis research & therapy

authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

更新日期：2003-01-01 00:00:00

abstract：:The development of spontaneous autoimmunity in inbred strains of rodents has allowed us to investigate the molecular basis of chronic inflammatory disease in ways that would not be possible in humans. Recently, two new mouse models of autoimmune inflammatory polyarthritis have been reported that demonstrate how altera...

journal_title：Arthritis research & therapy

authors： Cope AP

更新日期：2004-01-01 00:00:00

abstract：:Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding ...

journal_title：Arthritis research & therapy

authors： Youinou P,Putterman C

更新日期：2009-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：INTRODUCTION:Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of ...

journal_title：Arthritis research & therapy

authors： Dalbeth N,Pool B,Smith T,Callon KE,Lobo M,Taylor WJ,Jones PB,Cornish J,McQueen FM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

journal_title：Arthritis research & therapy

authors： Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

journal_title：Arthritis research & therapy

authors： Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:The effect of low-intensity pulsed ultrasound (LIPUS) on cell growth was examined in three-dimensional-cultured chondrocytes with a collagen sponge. To elucidate the mechanisms underlying the mechanical activation of chondrocytes, intracellular signaling pathways through the Ras/mitogen-activated protein k...

journal_title：Arthritis research & therapy

authors： Takeuchi R,Ryo A,Komitsu N,Mikuni-Takagaki Y,Fukui A,Takagi Y,Shiraishi T,Morishita S,Yamazaki Y,Kumagai K,Aoki I,Saito T

更新日期：2008-01-01 00:00:00

abstract：:An impaired differentiation of naive CD4+ T cells towards Th2 cells may contribute to the chronic tissue-destructive T-cell activity in rheumatoid arthritis (RA). The differentiation of naive CD4+ T cells into memory Th2 cells by IL-7 in comparison with that by IL-4 was studied in RA patients and in healthy controls. ...

journal_title：Arthritis research & therapy

authors： van Roon JA,Glaudemans CA,Bijlsma JW,Lafeber FP

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic risk in RA, and explore whether these relationships were similar to those for persons without RA....

journal_title：Arthritis research & therapy

authors： Bartlett DB,Connelly MA,AbouAssi H,Bateman LA,Tune KN,Huebner JL,Kraus VB,Winegar DA,Otvos JD,Kraus WE,Huffman KM

更新日期：2016-04-12 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified. METHODS:We recruited patients with at least 1 SARD ...

journal_title：Arthritis research & therapy

authors： Reynolds JA,Briggs TA,Rice GI,Darmalinggam S,Bondet V,Bruce E,Khan M,Haque S,Chinoy H,Herrick AL,McCarthy EM,Zeef L,Hayes A,Duffy D,Parker B,Bruce IN

更新日期：2019-06-14 00:00:00

abstract：INTRODUCTION:Interleukin-1 (IL-1) blockade is the treatment of choice of cryopyrin associated periodic syndromes (CAPS). Anti-IL-1 monoclonal antibody (canakinumab) was recently registered. However no clear data are available on the optimal schedule of administration of this drug. The aim of the present study was to an...

journal_title：Arthritis research & therapy

authors： Caorsi R,Lepore L,Zulian F,Alessio M,Stabile A,Insalaco A,Finetti M,Battagliese A,Martini G,Bibalo C,Martini A,Gattorno M

更新日期：2013-02-26 00:00:00

abstract：:This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alterna...

journal_title：Arthritis research & therapy

authors： Goldkind L,Simon LS

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). METHODS:All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA,...

journal_title：Arthritis research & therapy

authors： Vela P,Sanchez-Piedra C,Perez-Garcia C,Castro-Villegas MC,Freire M,Mateo L,Díaz-Torné C,Bohorquez C,Blanco-Madrigal JM,Ros-Vilamajo I,Gómez S,Caño R,Sánchez-Alonso F,Díaz-González F,Gómez-Reino JJ

更新日期：2020-06-15 00:00:00

abstract：:B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of c...

journal_title：Arthritis research & therapy

authors： Dörner T,Jacobi AM,Lipsky PE

更新日期：2009-01-01 00:00:00