Impact of body weight on the achievement of minimal disease activity in patients with rheumatic diseases: a systematic review and meta-analysis.

abstract：:Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the ...

journal_title：Arthritis research & therapy

authors： Masi AT

更新日期：2014-01-01 00:00:00

abstract：:Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat severe pain according to the WHO three-step ladder. To examine the incidence of common adverse events of opioi...

journal_title：Arthritis research & therapy

authors： Moore RA,McQuay HJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

journal_title：Arthritis research & therapy

authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

更新日期：2015-08-28 00:00:00

abstract：INTRODUCTION:The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. METHODS:Thirty-one female subjects with OA ...

journal_title：Arthritis research & therapy

authors： Helmark IC,Mikkelsen UR,Børglum J,Rothe A,Petersen MC,Andersen O,Langberg H,Kjaer M

更新日期：2010-01-01 00:00:00

abstract：:Cardiovascular event rates are markedly increased in rheumatoid arthritis (RA), and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to cardiovascular disease in RA await elucidation. The present study comprises three components. First, we compared b...

journal_title：Arthritis research & therapy

authors： Dessein PH,Joffe BI,Singh S

更新日期：2005-01-01 00:00:00

abstract：:Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell ...

journal_title：Arthritis research & therapy

authors： Gillespie MT

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metal...

journal_title：Arthritis research & therapy

authors： Choi HM,Lee YA,Lee SH,Hong SJ,Hahm DH,Choi SY,Yang HI,Yoo MC,Kim KS

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recogniz...

journal_title：Arthritis research & therapy

authors： Charpin C,Martin M,Balandraud N,Roudier J,Auger I

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who ...

journal_title：Arthritis research & therapy

authors： Chen J,Luo Y,Zhao M,Wu D,Yang Y,Zhang W,Shen M

更新日期：2019-11-12 00:00:00

abstract：:Osteoporosis results from a loss of bone mass and bone structure such that the bone becomes weak and fractures with very little trauma. Until recently, the approved osteoporosis therapies prevented more bone loss by altering osteoclast activity and lifespan. Recently, attention has turned away from osteoclast inhibiti...

journal_title：Arthritis research & therapy

authors： Lane NE,Kelman A

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered arthritis. To understand this tolerogenic mechanism, we performed a descripti...

journal_title：Arthritis research & therapy

authors： Chalise J,Narendra S,Paudyal B,Magnusson M

更新日期：2013-10-03 00:00:00

abstract：:Inhibition of NF-kappaB is known to be effective in reducing both inflammation and bone destruction in animal models of arthritis. Our previous study demonstrated that a small cell-permeable NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses expression of proinflammatory cytokines and ameliorates ...

journal_title：Arthritis research & therapy

authors： Kubota T,Hoshino M,Aoki K,Ohya K,Komano Y,Nanki T,Miyasaka N,Umezawa K

更新日期：2007-01-01 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different BALB/c colonies develop proteoglycan-induced arthritis and proteoglycan-induced spondylitis in res...

journal_title：Arthritis research & therapy

authors： Farkas B,Boldizsar F,Tarjanyi O,Laszlo A,Lin SM,Hutas G,Tryniszewska B,Mangold A,Nagyeri G,Rosenzweig HL,Finnegan A,Mikecz K,Glant TT

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the share...

journal_title：Arthritis research & therapy

authors： Ferreiro-Iglesias A,Calaza M,Perez-Pampin E,Lopez Longo FJ,Marenco JL,Blanco FJ,Narvaez J,Navarro F,Cañete JD,de la Serna AR,Gonzalez-Alvaro I,Herrero-Beaumont G,Pablos JL,Balsa A,Fernandez-Gutierrez B,Caliz R,Gomez-Reino

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS:A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography...

journal_title：Arthritis research & therapy

authors： Guillén-Del-Castillo A,Simeón-Aznar CP,Callejas-Moraga EL,Tolosa-Vilella C,Alonso-Vila S,Fonollosa-Pla V,Selva-O'Callaghan A

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawal of the bDMARD. Results from published studies indicate that some patients will maintain remission;...

journal_title：Arthritis research & therapy

authors： Tanaka Y,Smolen JS,Jones H,Szumski A,Marshall L,Emery P

更新日期：2019-07-05 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：INTRODUCTION:A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little information as to the gene activity changes occurring during the disease process. Transcriptional profiling generates a 'snapshot' of the sampled cells...

journal_title：Arthritis research & therapy

authors： Pimentel-Santos FM,Ligeiro D,Matos M,Mourão AF,Costa J,Santos H,Barcelos A,Godinho F,Pinto P,Cruz M,Fonseca JE,Guedes-Pinto H,Branco JC,Brown MA,Thomas GP

更新日期：2011-04-07 00:00:00

abstract：INTRODUCTION:Data from clinical studies on the long-term efficacy and safety of anti-tumor necrosis factor (TNF)-α therapy in patients with ankylosing spondylitis (AS) are scarce. This is the first report on continuous treatment with the TNFα fusion protein etanercept over seven years (y). METHODS:Overall, 26 patients...

journal_title：Arthritis research & therapy

authors： Baraliakos X,Haibel H,Fritz C,Listing J,Heldmann F,Braun J,Sieper J

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Pathological bone changes differ considerably between inflammatory arthritic diseases and most studies have focused on bone erosion. Collagen-induced arthritis (CIA) is a model for rheumatoid arthritis, which, in addition to bone erosion, demonstrates bone formation at the time of clinical manifestations. ...

journal_title：Arthritis research & therapy

authors： Denninger KC,Litman T,Marstrand T,Moller K,Svensson L,Labuda T,Andersson Å

更新日期：2015-03-05 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support...

journal_title：Arthritis research & therapy

authors： Sato M,Uchida K,Nakajima H,Miyazaki T,Guerrero AR,Watanabe S,Roberts S,Baba H

更新日期：2012-02-07 00:00:00

abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

journal_title：Arthritis research & therapy

authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

更新日期：2018-04-10 00:00:00

abstract：INTRODUCTION:Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose-derived stromal cell (ASC) injection in the healing process on cartilage, synovial membrane and menisci in an experimental rabbit model. ME...

journal_title：Arthritis research & therapy

authors： Desando G,Cavallo C,Sartoni F,Martini L,Parrilli A,Veronesi F,Fini M,Giardino R,Facchini A,Grigolo B

更新日期：2013-01-29 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-α) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis (AS). ...

journal_title：Arthritis research & therapy

authors： Arends S,Spoorenberg A,Houtman PM,Leijsma MK,Bos R,Kallenberg CG,Groen H,Brouwer E,van der Veer E

更新日期：2012-04-30 00:00:00

abstract：:This prospective study examined the association between physical activity and the incidence of self-reported stiff or painful joints (SPJ) among mid-age women and older women over a 3-year period. Data were collected from cohorts of mid-age (48-55 years at Time 1; n = 4,780) and older women (72-79 years at Time 1; n =...

journal_title：Arthritis research & therapy

authors： Heesch KC,Miller YD,Brown WJ

更新日期：2007-01-01 00:00:00

abstract：:There is increasing recognition that central pain sensitivity plays an important role in pain severity among patients with osteoarthritis. Murphy and colleagues identified clusters of patients with osteoarthritis according to pain severity and accompanying symptoms, and one of these groups appeared to have a greater d...

journal_title：Arthritis research & therapy

authors： Allen K

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional role in the pathogenesis in SLE. METHODS:Gene expression levels in peripheral blood cells (PBLs)...

journal_title：Arthritis research & therapy

authors： Feng X,Li R,Huang J,Zhang H,Zhu L,Hua B,Tsao BP,Sun L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim of this study was to detect the levels of ...

journal_title：Arthritis research & therapy

authors： Wu Y,Zhang F,Ma J,Zhang X,Wu L,Qu B,Xia S,Chen S,Tang Y,Shen N

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. METHODS:To generate expression of the CII-peptide sp...

journal_title：Arthritis research & therapy

authors： Andersson SE,Eneljung T,Tengvall S,Jirholt P,Stern A,Henningsson L,Liang B,Thorarinsdottir K,Kihlberg J,Holmdahl R,Mårtensson IL,Gustafsson K,Gjertsson I

更新日期：2016-06-14 00:00:00