Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests.

abstract：BACKGROUND:The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis. METHODS:Fine n...

journal_title：Arthritis research & therapy

authors： Wang DM,Lin L,Peng JH,Gong Y,Hou ZD,Chen SB,Xiao ZY

更新日期：2018-06-08 00:00:00

abstract：:Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7alpha-hydroxy-dehydroepiandrosterone (7alpha-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone, can block glucocorticoid-induced immune suppression. Formation of 7alpha-OH-DHEA is catalyzed by act...

journal_title：Arthritis research & therapy

authors： Dulos J,Kaptein A,Kavelaars A,Heijnen C,Boots A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

journal_title：Arthritis research & therapy

authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

更新日期：2015-08-28 00:00:00

abstract：:The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and, in particular, a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have special mer...

journal_title：Arthritis research & therapy

authors： Smolen JS,Aletaha D

更新日期：2009-01-01 00:00:00

abstract：:In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by the associated high rates of psychological distress and somatisation. We address the hypothesis that the latte...

journal_title：Arthritis research & therapy

authors： McBeth J,Chiu YH,Silman AJ,Ray D,Morriss R,Dickens C,Gupta A,Macfarlane GJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and potency for IL-6 receptor (IL-6R), combined with an extended half-life by targeting human serum a...

journal_title：Arthritis research & therapy

authors： Van Roy M,Ververken C,Beirnaert E,Hoefman S,Kolkman J,Vierboom M,Breedveld E,'t Hart B,Poelmans S,Bontinck L,Hemeryck A,Jacobs S,Baumeister J,Ulrichts H

更新日期：2015-05-20 00:00:00

abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

journal_title：Arthritis research & therapy

authors： Mahler M,Fritzler MJ

更新日期：2009-01-01 00:00:00

abstract：:Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review ...

journal_title：Arthritis research & therapy

authors： Ramiro S,Machado P,Singh JA,Landewé RB,da Silva JA

更新日期：2010-01-01 00:00:00

abstract：:Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the ...

journal_title：Arthritis research & therapy

authors： Masi AT

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to contribute to arthritic pain is ectopic nerve sprouting; however, neu...

journal_title：Arthritis research & therapy

authors： Jimenez-Andrade JM,Mantyh PW

更新日期：2012-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

journal_title：Arthritis research & therapy

authors： Moulton VR,Tsokos GC

更新日期：2011-03-17 00:00:00

abstract：INTRODUCTION:Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affect patients' overall quality of life. A consensus regarding the best patient outcomes to be measur...

journal_title：Arthritis research & therapy

authors： Wallen GR,Middleton KR,Rivera-Goba MV,Mittleman BB

更新日期：2011-01-05 00:00:00

abstract：BACKGROUND:The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). METHODS:Serum from patients with RA and osteoarthritis (OA), and healthy controls, and synov...

journal_title：Arthritis research & therapy

authors： Min HK,Won JY,Kim BM,Lee KA,Lee SJ,Lee SH,Kim HR,Kim KW

更新日期：2020-09-23 00:00:00

abstract：INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

journal_title：Arthritis research & therapy

authors： O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). METHODS:A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography...

journal_title：Arthritis research & therapy

authors： Guillén-Del-Castillo A,Simeón-Aznar CP,Callejas-Moraga EL,Tolosa-Vilella C,Alonso-Vila S,Fonollosa-Pla V,Selva-O'Callaghan A

更新日期：2018-12-19 00:00:00

abstract：INTRODUCTION:Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue kne...

journal_title：Arthritis research & therapy

authors： Peat G,Bergknut C,Frobell R,Jöud A,Englund M

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

journal_title：Arthritis research & therapy

authors： Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

journal_title：Arthritis research & therapy

authors： Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

更新日期：2019-12-04 00:00:00

abstract：:Experimental arthritis models are considered valuable tools for delineating mechanisms of inflammation and autoimmune phenomena. Use of microarray-based methods represents a new and challenging approach that allows molecular dissection of complex autoimmune diseases such as arthritis. In order to characterize the temp...

journal_title：Arthritis research & therapy

authors： Rioja I,Clayton CL,Graham SJ,Life PF,Dickson MC

更新日期：2005-01-01 00:00:00

abstract：:B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of c...

journal_title：Arthritis research & therapy

authors： Dörner T,Jacobi AM,Lipsky PE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawal of the bDMARD. Results from published studies indicate that some patients will maintain remission;...

journal_title：Arthritis research & therapy

authors： Tanaka Y,Smolen JS,Jones H,Szumski A,Marshall L,Emery P

更新日期：2019-07-05 00:00:00

abstract：:The characteristic of a biomarker that makes it a useful surrogate is the ability to identify a high risk of clinically important benefits or harms occurring in the future. A number of definitions or descriptions of surrogate definition have been put forward. Most recently the Institute of Medicine of the National Aca...

journal_title：Arthritis research & therapy

authors： Andrew Moore R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus cultured under conditions of increased osmolarity. BDNF is now known to be involved in a number of biologic functions, including regula...

journal_title：Arthritis research & therapy

authors： Gruber HE,Ingram JA,Hoelscher G,Zinchenko N,Norton HJ,Hanley EN Jr

更新日期：2008-01-01 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：:Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding ...

journal_title：Arthritis research & therapy

authors： Youinou P,Putterman C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort. METHODS:All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Sp...

journal_title：Arthritis research & therapy

authors： Narváez J,Borrell H,Sánchez-Alonso F,Rúa-Figueroa I,López-Longo FJ,Galindo-Izquierdo M,Calvo-Alén J,Fernández-Nebro A,Olivé A,Andreu JL,Martínez-Taboada V,Nolla JM,Pego-Reigosa JM,RELESSER Study Group.

更新日期：2018-12-19 00:00:00