Antibody engineering to develop new antirheumatic therapies.

Abstract:

:There has been a therapeutic revolution in rheumatology over the past 15 years, characterised by a move away from oral immuno-suppressive drugs toward parenteral targeted biological therapies. The potency and relative safety of the newer agents has facilitated a more aggressive approach to treatment, with many more patients achieving disease remission. There is even a prevailing sense that disease 'cure' may be a realistic goal in the future. These developments were underpinned by an earlier revolution in molecular biology and protein engineering as well as key advances in our understanding of rheumatoid arthritis pathogenesis. This review will focus on antibody engineering as the key driver behind our current and developing range of antirheumatic treatments.

journal_name

Arthritis Res Ther

authors

Isaacs JD

doi

10.1186/ar2594

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

225

issue

3

eissn

1478-6354

issn

1478-6362

pii

ar2594

journal_volume

11

pub_type

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