Antibody engineering to develop new antirheumatic therapies.


:There has been a therapeutic revolution in rheumatology over the past 15 years, characterised by a move away from oral immuno-suppressive drugs toward parenteral targeted biological therapies. The potency and relative safety of the newer agents has facilitated a more aggressive approach to treatment, with many more patients achieving disease remission. There is even a prevailing sense that disease 'cure' may be a realistic goal in the future. These developments were underpinned by an earlier revolution in molecular biology and protein engineering as well as key advances in our understanding of rheumatoid arthritis pathogenesis. This review will focus on antibody engineering as the key driver behind our current and developing range of antirheumatic treatments.


Arthritis Res Ther


Isaacs JD




Has Abstract


2009-01-01 00:00:00














  • Low-intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis.

    abstract:INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

    更新日期:2015-10-07 00:00:00

  • Signaling by STATs.

    abstract::A variety of cytokines and growth factors use the Janus kinase (Jak)-STAT signaling pathway to transmit extracellular signals to the nucleus. STATs (signal transducers and activators of transcription) are latent cytoplasmic transcription factors. There are seven mammalian STATs and they have critical, nonredundant rol...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审


    authors: Ivashkiv LB,Hu X

    更新日期:2004-01-01 00:00:00

  • Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis.

    abstract:INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

    更新日期:2012-04-30 00:00:00

  • Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects.

    abstract:INTRODUCTION:A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little information as to the gene activity changes occurring during the disease process. Transcriptional profiling generates a 'snapshot' of the sampled cells...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Pimentel-Santos FM,Ligeiro D,Matos M,Mourão AF,Costa J,Santos H,Barcelos A,Godinho F,Pinto P,Cruz M,Fonseca JE,Guedes-Pinto H,Branco JC,Brown MA,Thomas GP

    更新日期:2011-04-07 00:00:00

  • Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.

    abstract:INTRODUCTION:The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this study was t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Li Y,Lee PY,Sobel ES,Narain S,Satoh M,Segal MS,Reeves WH,Richards HB

    更新日期:2009-01-01 00:00:00

  • Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.

    abstract:BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

    更新日期:2021-01-19 00:00:00

  • Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes.

    abstract:INTRODUCTION:Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Klingberg E,Lorentzon M,Göthlin J,Mellström D,Geijer M,Ohlsson C,Atkinson EJ,Khosla S,Carlsten H,Forsblad-d'Elia H

    更新日期:2013-01-01 00:00:00

  • Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.

    abstract:INTRODUCTION:The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Lee SI,Boyle DL,Berdeja A,Firestein GS

    更新日期:2012-02-21 00:00:00

  • Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis.

    abstract:INTRODUCTION:Inflammatory arthritis is associated with increased bone resorption and suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation and this protein has been proposed to be a master regulator of bone remodelling in inflammatory arthritis. ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Hardy R,Juarez M,Naylor A,Tu J,Rabbitt EH,Filer A,Stewart PM,Buckley CD,Raza K,Cooper MS

    更新日期:2012-10-18 00:00:00

  • Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.

    abstract::Reports of the use of HLA-B27/peptide tetrameric complexes to study peptide-specific CD8+ T cells in HLA-B27+-related diseases are rare. To establish HLA-B27 tetramers we first compared the function of HLA-B27 tetramers with HLA-A2 tetramers by using viral epitopes. HLA-B27 and HLA-A2 tetramers loaded with immunodomin...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Appel H,Kuon W,Kuhne M,Wu P,Kuhlmann S,Kollnberger S,Thiel A,Bowness P,Sieper J

    更新日期:2004-01-01 00:00:00

  • Inducing articular cartilage phenotype in costochondral cells.

    abstract:INTRODUCTION:Costochondral cells may be isolated with minimal donor site morbidity and are unaffected by pathologies of the diarthrodial joints. Identification of optimal exogenous stimuli will allow abundant and robust hyaline articular cartilage to be formed from this cell source. METHODS:In a three factor, two leve...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Murphy MK,DuRaine GD,Reddi A,Hu JC,Athanasiou KA

    更新日期:2013-01-01 00:00:00

  • Clinical predictors of multiple failure to biological therapy in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

    更新日期:2020-12-09 00:00:00

  • Patients' preferences for osteoporosis drug treatment: a discrete-choice experiment.

    abstract:INTRODUCTION:The patient's perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication attributes, and to establish how patients trade between these attributes. METHODS:A discrete choic...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Hiligsmann M,Dellaert BG,Dirksen CD,van der Weijden T,Goemaere S,Reginster JY,Watson V,Boonen A

    更新日期:2014-01-31 00:00:00

  • Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis.

    abstract:INTRODUCTION:Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5 + CXCR3 + CCR6- (Tfh-Th1), CXCR5 + CXCR3-CCR6- (Tfh-Th2) and CXCR5 + CXCR3-CCR6+ (Tfh-Th17). Our objective was to study the B cell ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Arroyo-Villa I,Bautista-Caro MB,Balsa A,Aguado-Acín P,Bonilla-Hernán MG,Plasencia C,Villalba A,Nuño L,Puig-Kröger A,Martín-Mola E,Miranda-Carús ME

    更新日期:2014-12-05 00:00:00

  • Post-traumatic osteoarthritis following ACL injury.

    abstract::Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审


    authors: Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

    更新日期:2020-03-24 00:00:00

  • Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials.

    abstract:INTRODUCTION:The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS. METHODS:The Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDISCUS (through April 2009) and the re...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,meta分析,评审


    authors: Häuser W,Klose P,Langhorst J,Moradi B,Steinbach M,Schiltenwolf M,Busch A

    更新日期:2010-01-01 00:00:00

  • The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy.

    abstract:BACKGROUND:Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities i...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验


    authors: Jonsson MK,Hensvold AH,Hansson M,Aga AB,Sexton J,Mathsson-Alm L,Cornillet M,Serre G,Lillegraven S,Fevang BS,Catrina AI,Haavardsholm EA

    更新日期:2018-07-13 00:00:00

  • A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease.

    abstract:BACKGROUND:Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis. In this study, we evaluated how these TLR4 ligands may drive pathogenic processes and whether the fine profiling of anti-citrullinated protein antibodies (ACPA) based on t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Hatterer E,Shang L,Simonet P,Herren S,Daubeuf B,Teixeira S,Reilly J,Elson G,Nelson R,Gabay C,Sokolove J,McInnes IB,Kosco-Vilbois M,Ferlin W,Monnet E,De Min C

    更新日期:2016-10-06 00:00:00

  • Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20).

    abstract:: ...

    journal_title:Arthritis research & therapy

    pub_type: 信件


    authors: Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

    更新日期:2018-12-10 00:00:00

  • Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register.

    abstract:OBJECTIVES:To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). METHODS:All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA,...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Vela P,Sanchez-Piedra C,Perez-Garcia C,Castro-Villegas MC,Freire M,Mateo L,Díaz-Torné C,Bohorquez C,Blanco-Madrigal JM,Ros-Vilamajo I,Gómez S,Caño R,Sánchez-Alonso F,Díaz-González F,Gómez-Reino JJ

    更新日期:2020-06-15 00:00:00

  • The use and abuse of commercial kits used to detect autoantibodies.

    abstract::The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审


    authors: Fritzler MJ,Wiik A,Fritzler ML,Barr SG

    更新日期:2003-01-01 00:00:00

  • Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population.

    abstract:BACKGROUND:Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not been thoroughly examined. In this study, we carried out genome-wide association study (GWAS) in the Tha...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Tangtanatakul P,Thumarat C,Satproedprai N,Kunhapan P,Chaiyasung T,Klinchanhom S,Wang YF,Wei W,Wongshinsri J,Chiewchengchol D,Rodsaward P,Ngamjanyaporn P,Suangtamai T,Mahasirimongkol S,Pisitkun P,Hirankarn N

    更新日期:2020-08-08 00:00:00

  • Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Cardiovascular disease (CVD) is common and a major cause of mortality. Studies on cardiovascular morbidity are abundant, whereas mortality studies focusing on cardiovascular outcomes are scarce. The aim of this study was to investigate cau...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Gustafsson JT,Simard JF,Gunnarsson I,Elvin K,Lundberg IE,Hansson LO,Larsson A,Svenungsson E

    更新日期:2012-01-01 00:00:00

  • A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.

    abstract::Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Matsumoto I,Zhang H,Muraki Y,Hayashi T,Yasukochi T,Kori Y,Goto D,Ito S,Tsutsumi A,Sumida T

    更新日期:2005-01-01 00:00:00

  • Validating English- and Spanish-language patient-reported outcome measures in underserved patients with rheumatic disease.

    abstract:INTRODUCTION:Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affect patients' overall quality of life. A consensus regarding the best patient outcomes to be measur...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Wallen GR,Middleton KR,Rivera-Goba MV,Mittleman BB

    更新日期:2011-01-05 00:00:00

  • BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.

    abstract:INTRODUCTION:The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different BALB/c colonies develop proteoglycan-induced arthritis and proteoglycan-induced spondylitis in res...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Farkas B,Boldizsar F,Tarjanyi O,Laszlo A,Lin SM,Hutas G,Tryniszewska B,Mangold A,Nagyeri G,Rosenzweig HL,Finnegan A,Mikecz K,Glant TT

    更新日期:2009-01-01 00:00:00

  • Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model.

    abstract::Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

    journal_title:Arthritis research & therapy

    pub_type: 评论,社论


    authors: van der Kraan PM

    更新日期:2010-01-01 00:00:00

  • Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model.

    abstract:BACKGROUND:The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destruction, an...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Atkinson SM,Bleil J,Maier R,Kühl AA,Thorn M,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A,Syrbe U

    更新日期:2016-01-23 00:00:00

  • Regenerative potential of human muscle stem cells in chronic inflammation.

    abstract:INTRODUCTION:Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Duijnisveld BJ,Bigot A,Beenakker KG,Portilho DM,Raz V,van der Heide HJ,Visser CP,Chaouch S,Mamchaoui K,Westendorp RG,Mouly V,Butler-Browne GS,Nelissen RG,Maier AB

    更新日期:2011-01-01 00:00:00

  • Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis.

    abstract:BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章


    authors: Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

    更新日期:2016-04-12 00:00:00