Pulmonary arterial hypertension in scleroderma: care gaps in screening.

abstract：INTRODUCTION:Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial cit...

journal_title：Arthritis research & therapy

authors： Makrygiannakis D,Revu S,Engström M,af Klint E,Nicholas AP,Pruijn GJ,Catrina AI

更新日期：2012-01-27 00:00:00

abstract：:Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported t...

journal_title：Arthritis research & therapy

authors： Kinderlerer AR,Steinberg R,Johns M,Harten SK,Lidington EA,Haskard DO,Maxwell PH,Mason JC

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis. METHODS:Human CD14+ cells were isolated fro...

journal_title：Arthritis research & therapy

authors： Adamopoulos IE,Chao CC,Geissler R,Laface D,Blumenschein W,Iwakura Y,McClanahan T,Bowman EP

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:It is known that anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we studied ACPA-negative arthralgia patients who were considered prone to progress to RA for local sub...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Huizinga TW,Reijnierse M,van der Helm-van Mil AH

更新日期：2014-04-10 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by synovial macrophage activation. TA injections might influence macrophage activation and subsequently...

journal_title：Arthritis research & therapy

authors： Siebelt M,Korthagen N,Wei W,Groen H,Bastiaansen-Jenniskens Y,Müller C,Waarsing JH,de Jong M,Weinans H

更新日期：2015-12-05 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

journal_title：Arthritis research & therapy

authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of RA are largely unknown. We investigated the role of Dickkopf-related protein 1 (DKK1) produced by syn...

journal_title：Arthritis research & therapy

authors： Juarez M,McGettrick HM,Scheel-Toellner D,Yeo L,Spengler J,de Paz B,Hardy R,Cooper M,Raza K,Buckley CD,Filer A

更新日期：2016-01-19 00:00:00

abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc). Screening guidelines for PAH recommend multiple investigations, including annual echocardiography, which together have low specificity and may not be cost-effective. We sought to evaluate the predictive accurac...

journal_title：Arthritis research & therapy

authors： Thakkar V,Stevens W,Prior D,Youssef P,Liew D,Gabbay E,Roddy J,Walker JG,Zochling J,Sahhar J,Nash P,Lester S,Rischmueller M,Proudman SM,Nikpour M

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of patients diagnosed with RA do not use DMARDs, little is known about this group. We explored the char...

journal_title：Arthritis research & therapy

authors： Brown EM,Garneau KL,Tsao H,Solomon DH

更新日期：2014-01-29 00:00:00

abstract：INTRODUCTION:In many patients with rheumatoid arthritis (RA) subclinical disease activity can be detected with ultrasound (US), especially using power Doppler US (PDUS). However, PDUS may be highly dependent on the type of machine. This could create problems both in clinical trials and in daily clinical practice. To cl...

journal_title：Arthritis research & therapy

authors： Ten Cate DF,Luime JJ,van der Ven M,Hazes JM,Kooiman K,de Jong N,Bosch JG

更新日期：2013-10-24 00:00:00

abstract：INTRODUCTION:The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS. METHODS:The Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDISCUS (through April 2009) and the re...

journal_title：Arthritis research & therapy

authors： Häuser W,Klose P,Langhorst J,Moradi B,Steinbach M,Schiltenwolf M,Busch A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

journal_title：Arthritis research & therapy

authors： De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of A...

journal_title：Arthritis research & therapy

authors： Moxey J,Huq M,Proudman S,Sahhar J,Ngian GS,Walker J,Strickland G,Wilson M,Ross L,Major G,Roddy J,Stevens W,Nikpour M

更新日期：2019-02-14 00:00:00

abstract：:As translational clinical researchers familiar with the risk-benefit of hematopoietic stem cell transplantation in autoimmune diseases, we are intrigued by the recent report of umbilical cord mesenchymal stem cell (UC-MSC) transplantation in treatment-refractory systemic lupus erythematosus nephritis by Wang and colle...

journal_title：Arthritis research & therapy

authors： Woodworth TG,Furst DE

更新日期：2014-07-30 00:00:00

abstract：BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

journal_title：Arthritis research & therapy

authors： Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease ...

journal_title：Arthritis research & therapy

authors： Rastogi A,Kim H,Twomey JD,Hsieh AH

更新日期：2013-04-27 00:00:00

abstract：:Cartilage damage in osteoarthritis (OA) is considered an imbalance between catabolic and anabolic factors, favoring the catabolic side. We assessed whether adenoviral overexpression of transforming growth factor-beta (TGFbeta) enhanced cartilage repair and whether TGFbeta-induced fibrosis was blocked by local expressi...

journal_title：Arthritis research & therapy

authors： Blaney Davidson EN,Vitters EL,van den Berg WB,van der Kraan PM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional role in the pathogenesis in SLE. METHODS:Gene expression levels in peripheral blood cells (PBLs)...

journal_title：Arthritis research & therapy

authors： Feng X,Li R,Huang J,Zhang H,Zhu L,Hua B,Tsao BP,Sun L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share genetic and clinical features. IBD is associated with the presence of antibodies to a variety of commensal microorganisms including anti-Saccharomyces cerevesiae antibodies (ASCA), antineutrophil cytoplasmic antibodies (ANCA), anti-I2 (...

journal_title：Arthritis research & therapy

authors： Wallis D,Asaduzzaman A,Weisman M,Haroon N,Anton A,McGovern D,Targan S,Inman R

更新日期：2013-10-26 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serve...

journal_title：Arthritis research & therapy

authors： Snir O,Gomez-Cabrero D,Montes A,Perez-Pampin E,Gómez-Reino JJ,Seddighzadeh M,Klich KU,Israelsson L,Ding B,Catrina AI,Holmdahl R,Alfredsson L,Klareskog L,Tegnér J,Gonzalez A,Malmström V,Padyukov L

更新日期：2014-08-20 00:00:00

abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

journal_title：Arthritis research & therapy

authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

更新日期：2012-08-17 00:00:00

abstract：BACKGROUND:Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies have investigated the long-term stru...

journal_title：Arthritis research & therapy

authors： Wu D,Griffith JF,Lam SHM,Wong PCH,Shi L,Li EK,Cheng IT,Li TK,Hung VW,Qin L,Tam LS

更新日期：2019-12-04 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclear, but potential candidates include (a) intrinsic hyper-reactivity leading to polyclonal B-cell activation wit...

journal_title：Arthritis research & therapy

authors： Dörner T,Giesecke C,Lipsky PE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE:To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active ...

journal_title：Arthritis research & therapy

authors： Glimm AM,Sprenger LI,Haugen IK,Mansmann U,Hermann S,Häupl T,Hoff P,Burmester GR,Backhaus M,Le L,Ohrndorf S

更新日期：2019-09-18 00:00:00

abstract：INTRODUCTION:The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a plays a central role. In this study, plasma and urinary levels of C5a as well as renal C5a receptors (CD88 and C5L2) expression were investigated in patients wi...

journal_title：Arthritis research & therapy

authors： Yuan J,Gou SJ,Huang J,Hao J,Chen M,Zhao MH

更新日期：2012-06-12 00:00:00

abstract：:A variety of cytokines and growth factors use the Janus kinase (Jak)-STAT signaling pathway to transmit extracellular signals to the nucleus. STATs (signal transducers and activators of transcription) are latent cytoplasmic transcription factors. There are seven mammalian STATs and they have critical, nonredundant rol...

journal_title：Arthritis research & therapy

authors： Ivashkiv LB,Hu X

更新日期：2004-01-01 00:00:00

abstract：:A growing body of literature has demonstrated that the multifunctional glycoprotein osteopontin (OPN), has a role in type I interferon (IFN) production and may be involved in systemic lupus erythematosus (SLE) pathogenesis. A recent report has provided further support for this, demonstrating an association between rai...

journal_title：Arthritis research & therapy

authors： Briggs TA

更新日期：2013-03-08 00:00:00