当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > DMARD non-use in low-income, elderly rheumatoid arthritis patients: results of 86 structured interviews.

DMARD non-use in low-income, elderly rheumatoid arthritis patients: results of 86 structured interviews.

Abstract：

INTRODUCTION:Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of patients diagnosed with RA do not use DMARDs, little is known about this group. We explored the characteristics, experiences, and knowledge of a low-income, elderly RA population not currently using DMARDs, or receiving care from a rheumatologist. METHODS:We administered structured telephone interviews to participants enrolled in a large pharmacy benefits program for the elderly who had two diagnoses of RA ≥7 days apart and no DMARD prescriptions or rheumatologist visits in the prior year. The interview contained questions concerning each participant's sociodemographic information, disease activity, DMARD experiences, and the Modified Health Assessment Questionnaire (MHAQ). We described responses and compared prior users with never users. RESULTS:A total of 86 people completed the interview. The mean age was 80 years and 89% were female. On average, disease duration was 20 years. Mean MHAQ score was 0.55 (SD = 0.55). Of 86 participants, 19 had previously used DMARDs, 10 of whom discontinued them because of side effects or safety concerns. Among 67 never-users, 35 (52.2%) reported that their physicians had never offered them DMARDs, 13 (19.4%) described fear of side effects, and 49 (73.1%) knew nothing about them. Prior-users reported experiencing more-severe RA symptoms than never-users. CONCLUSIONS:We found that side effects or safety concerns were the primary cause for DMARD cessation among prior-users. Among never-users, most reported never discussing or being offered DMARDs, suggesting that an educational gap may deter patients with RA from using them.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Brown EM,Garneau KL,Tsao H,Solomon DH

doi

10.1186/ar4459

subject

Has Abstract

pub_date

2014-01-29 00:00:00

pages

R30

issue

1

eissn

1478-6354

issn

1478-6362

pii

ar4459

journal_volume

16

pub_type

杂志文章

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • The use and abuse of commercial kits used to detect autoantibodies.

    abstract：:The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar782

    authors： Fritzler MJ,Wiik A,Fritzler ML,Barr SG

    更新日期：2003-01-01 00:00:00

  • A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin.

    abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2018-4

    authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

    更新日期：2019-11-27 00:00:00

  • Epigenetic modifications in rheumatoid arthritis.

    abstract：:Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the influence of epigenetic processes on the development of rheumatic diseases is probably as strong as the genetic ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar2500

    authors： Strietholt S,Maurer B,Peters MA,Pap T,Gay S

    更新日期：2008-01-01 00:00:00

  • Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases.

    abstract：INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3330

    authors： O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

    更新日期：2011-04-26 00:00:00

  • Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.

    abstract：BACKGROUND:Nearly all secreted proteins are glycosylated, and serum glycoproteins that exhibit disease-associated glycosylation changes have potential to be biomarkers. In rheumatoid arthritis (RA), C-reactive protein (CRP), and matrix metalloproteinase-3 (MMP-3) are widely used as serologic biomarkers, but they lack s...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-1013-2

    authors： Takeshita M,Kuno A,Suzuki K,Matsuda A,Shimazaki H,Nakagawa T,Otomo Y,Kabe Y,Suematsu M,Narimatsu H,Takeuchi T

    更新日期：2016-05-21 00:00:00

  • Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis.

    abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3038

    authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

    更新日期：2010-01-01 00:00:00

  • ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.

    abstract：:Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor precursor and extracellular matrix components such as procollagen, ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1783

    authors： Jones GC,Riley GP

    更新日期：2005-01-01 00:00:00

  • A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study.

    abstract：BACKGROUND:Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s13075-017-1387-9

    authors： Nakagawa J,Koyama Y,Kawakami A,Ueki Y,Tsukamoto H,Horiuchi T,Nagano S,Uchino A,Ota T,Akahoshi M,Akashi K

    更新日期：2017-08-11 00:00:00

  • Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus.

    abstract：INTRODUCTION:The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional role in the pathogenesis in SLE. METHODS:Gene expression levels in peripheral blood cells (PBLs)...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2972

    authors： Feng X,Li R,Huang J,Zhang H,Zhu L,Hua B,Tsao BP,Sun L

    更新日期：2010-01-01 00:00:00

  • Rheumatoid arthritis patients on persistent moderate disease activity on biologics have adverse 5-year outcome compared to persistent low-remission status and represent a heterogeneous group.

    abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02313-w

    authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

    更新日期：2020-09-29 00:00:00

  • Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.

    abstract：INTRODUCTION:The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this study was t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2590

    authors： Li Y,Lee PY,Sobel ES,Narain S,Satoh M,Segal MS,Reeves WH,Richards HB

    更新日期：2009-01-01 00:00:00

  • Toll-like receptors and NOD-like receptors in rheumatic diseases.

    abstract：:The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar2729

    authors： McCormack WJ,Parker AE,O'Neill LA

    更新日期：2009-01-01 00:00:00

  • TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype.

    abstract：BACKGROUND:Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1447-1

    authors： Quero L,Hanser E,Manigold T,Tiaden AN,Kyburz D

    更新日期：2017-11-02 00:00:00

  • Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

    abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4086

    authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

    更新日期：2012-11-08 00:00:00

  • Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.

    abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disea...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13075-018-1604-1

    authors： Julià A,López-Longo FJ,Pérez Venegas JJ,Bonàs-Guarch S,Olivé À,Andreu JL,Aguirre-Zamorano MÁ,Vela P,Nolla JM,de la Fuente JLM,Zea A,Pego-Reigosa JM,Freire M,Díez E,Rodríguez-Almaraz E,Carreira P,Blanco R,Taboada VM,Ló

    更新日期：2018-05-30 00:00:00

  • Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody-negative arthralgia patients at risk for rheumatoid arthritis.

    abstract：INTRODUCTION:It is known that anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) has a preclinical phase. Whether this phase is also present in ACPA-negative RA is unknown. To determine this, we studied ACPA-negative arthralgia patients who were considered prone to progress to RA for local sub...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4536

    authors： van Steenbergen HW,van Nies JA,Huizinga TW,Reijnierse M,van der Helm-van Mil AH

    更新日期：2014-04-10 00:00:00

  • Novel autoantibodies and clinical phenotypes in adult and juvenile myositis.

    abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3275

    authors： Betteridge ZE,Gunawardena H,McHugh NJ

    更新日期：2011-03-18 00:00:00

  • Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.

    abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2795

    authors： Lundy SK,Fox DA

    更新日期：2009-01-01 00:00:00

  • Broad-range PCR, cloning and sequencing of the full 16S rRNA gene for detection of bacterial DNA in synovial fluid samples of Tunisian patients with reactive and undifferentiated arthritis.

    abstract：INTRODUCTION:Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targeting the 16S rRNA gene in patients with reactive and other forms of arthritis and to screen for th...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2748

    authors： Siala M,Gdoura R,Fourati H,Rihl M,Jaulhac B,Younes M,Sibilia J,Baklouti S,Bargaoui N,Sellami S,Sghir A,Hammami A

    更新日期：2009-01-01 00:00:00

  • Low back pain precedes the development of new knee pain in the elderly population; a novel predictive score from a longitudinal cohort study.

    abstract：BACKGROUND:To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data. METHODS:We collected a questionnaire on self-reported knee pain and demographic data in a systema...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-1884-0

    authors： Ito H,Tominari S,Tabara Y,Nakayama T,Furu M,Kawata T,Azukizawa M,Setoh K,Kawaguchi T,Matsuda F,Matsuda S,Nagahama Study group.

    更新日期：2019-04-15 00:00:00

  • Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?

    abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3657

    authors： Henrotin Y,Mobasheri A,Marty M

    更新日期：2012-01-30 00:00:00

  • Time to achieve remission determines time to be in remission.

    abstract：INTRODUCTION:Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the associatio...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3027

    authors： Schipper LG,Fransen J,den Broeder AA,Van Riel PL

    更新日期：2010-01-01 00:00:00

  • Suppression of endothelial cell activity by inhibition of TNFα.

    abstract：INTRODUCTION:TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function and angiogenesis. METHODS:Human dermal microvascular endothelial cells (HMVECs) were stimulated wit...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3812

    authors： Shu Q,Amin MA,Ruth JH,Campbell PL,Koch AE

    更新日期：2012-04-25 00:00:00

  • Applying science in practice: the optimization of biological therapy in rheumatoid arthritis.

    abstract：:Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3149

    authors： Ramiro S,Machado P,Singh JA,Landewé RB,da Silva JA

    更新日期：2010-01-01 00:00:00

  • Rule-based and machine learning algorithms identify patients with systemic sclerosis accurately in the electronic health record.

    abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2092-7

    authors： Jamian L,Wheless L,Crofford LJ,Barnado A

    更新日期：2019-12-30 00:00:00

  • Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

    abstract：INTRODUCTION:Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects. METHODS:Human Col I...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3173

    authors： El-Bikai R,Welman M,Margaron Y,Côté JF,Macqueen L,Buschmann MD,Fahmi H,Shi Q,Maghni K,Fernandes JC,Benderdour M

    更新日期：2010-01-01 00:00:00

  • Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation.

    abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2963

    authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

    更新日期：2010-01-01 00:00:00

  • Giant cell arteritis: immune and vascular aging as disease risk factors.

    abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3358

    authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

    更新日期：2011-08-02 00:00:00

  • Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising.

    abstract：BACKGROUND:Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. METHODS:The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory ar...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1251-y

    authors： Curtis JR,Chen L,Higginbotham P,Nowell WB,Gal-Levy R,Willig J,Safford M,Coe J,O'Hara K,Sa'adon R

    更新日期：2017-03-07 00:00:00

  • Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study.

    abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1242-z

    authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

    更新日期：2017-02-10 00:00:00