Signaling by STATs.

abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

journal_title：Arthritis research & therapy

authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 ...

journal_title：Arthritis research & therapy

authors： Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

更新日期：2012-01-18 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

journal_title：Arthritis research & therapy

authors： Jamian L,Wheless L,Crofford LJ,Barnado A

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

journal_title：Arthritis research & therapy

authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

更新日期：2020-10-15 00:00:00

abstract：INTRODUCTION:In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atherosclerosis, in a series of Spanish patients with rheumatoid arthritis (RA) without clinically evident ca...

journal_title：Arthritis research & therapy

authors： González-Juanatey C,Llorca J,González-Gay MA

更新日期：2011-06-22 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the role of hand bone mineral density (BMD) loss analyzed with digital X-ray radiogrammetry (DXR) in early rheumatoid arthritis (RA) as a predictor for progression of joint damage. METHODS:In 379 patients with early RA, baseline and one-year hand BMD was measured w...

journal_title：Arthritis research & therapy

authors： Forslind K,Kälvesten J,Hafström I,Svensson B,BARFOT Study Group.

更新日期：2012-10-15 00:00:00

abstract：:Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it provides the diagnostic procedures required to asses a patient with vascul...

journal_title：Arthritis research & therapy

authors： Holle JU,Moosig F,Dalhoff K,Gross WL

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of phosphorylated signal transd...

journal_title：Arthritis research & therapy

authors： McInnes IB,Byers NL,Higgs RE,Lee J,Macias WL,Na S,Ortmann RA,Rocha G,Rooney TP,Wehrman T,Zhang X,Zuckerman SH,Taylor PC

更新日期：2019-08-02 00:00:00

abstract：INTRODUCTION:Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sl...

journal_title：Arthritis research & therapy

authors： Lee YC,Chibnik LB,Lu B,Wasan AD,Edwards RR,Fossel AH,Helfgott SM,Solomon DH,Clauw DJ,Karlson EW

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor in RA progression, which promotes fibroblast-like synoviocyte (FLS) proliferation, pannus formation, ...

journal_title：Arthritis research & therapy

authors： Sun W,Ma J,Zhao H,Xiao C,Zhong H,Ling H,Xie Z,Tian Q,Chen H,Zhang T,Chen M,Jin S,Wang J

更新日期：2020-03-27 00:00:00

abstract：INTRODUCTION:Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity. We hypothesize that augmented pain processing, fibromyalgic features, poorer menta...

journal_title：Arthritis research & therapy

authors： Joharatnam N,McWilliams DF,Wilson D,Wheeler M,Pande I,Walsh DA

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

journal_title：Arthritis research & therapy

authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

更新日期：2016-04-12 00:00:00

abstract：INTRODUCTION:Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of ...

journal_title：Arthritis research & therapy

authors： Happonen KE,Saxne T,Geborek P,Andersson M,Bengtsson AA,Hesselstrand R,Heinegård D,Blom AM

更新日期：2012-01-20 00:00:00

abstract：:The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and, in particular, a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have special mer...

journal_title：Arthritis research & therapy

authors： Smolen JS,Aletaha D

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE ...

journal_title：Arthritis research & therapy

authors： Meyer PW,Hodkinson B,Ally M,Musenge E,Wadee AA,Fickl H,Tikly M,Anderson R

更新日期：2011-01-01 00:00:00

abstract：:This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alterna...

journal_title：Arthritis research & therapy

authors： Goldkind L,Simon LS

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：:Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial h...

journal_title：Arthritis research & therapy

authors： Bauer K,Knipper A,Tu-Rapp H,Koczan D,Kreutzer HJ,Nizze H,Mix E,Thiesen HJ,Holmdahl R,Ibrahim SM

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Patients with recent-onset rheumatoid arthritis (RA) have impaired brachial artery endothelial function compared with controls matched for age, sex and cardiovascular risk factors. The present study examined endothelium-dependent (flow-mediated dilatation (FMD)) and independent (glyceryl trinitrate (GTN)-m...

journal_title：Arthritis research & therapy

authors： Hannawi S,Marwick TH,Thomas R

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The metabolic syndrome (MetS) may contribute to the excess cardiovascular burden observed in rheumatoid arthritis (RA). The prevalence and associations of the MetS in RA remain uncertain: systemic inflammation and anti-rheumatic therapy may contribute. Methotrexate (MTX) use has recently been linked to a r...

journal_title：Arthritis research & therapy

authors： Toms TE,Panoulas VF,John H,Douglas KM,Kitas GD

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Physical activity has been recommended to patients with knee osteoarthritis for improving their symptoms. However, it is still controversial if physical activity has effects on joint structures including cartilage volume. The aim of this study was to describe the associations between physical activity and ...

journal_title：Arthritis research & therapy

authors： Antony B,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Jones G,Ding C

更新日期：2015-10-26 00:00:00

abstract：INTRODUCTION:A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis in a cohort of Mexican Mestizo early RA patients, and to define a causal association between MetS...

journal_title：Arthritis research & therapy

authors： Parra-Salcedo F,Contreras-Yáñez I,Elías-López D,Aguilar-Salinas CA,Pascual-Ramos V

更新日期：2015-02-20 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might...

journal_title：Arthritis research & therapy

authors： Berthelot JM,Le Goff B,Maugars Y

更新日期：2019-11-13 00:00:00

abstract：:A dose-escalating phase II trial studied masitinib, an oral tyrosine kinase inhibitor, in 43 patients with rheumatoid arthritis. Masitinib induced American College of Rheumatology (ACR)20, ACR50 and ACR70 responses in 54%, 26% and 8% of patients, respectively. A placebo group was not included. Thirty-seven per cent of...

journal_title：Arthritis research & therapy

authors： Walker UA

更新日期：2009-01-01 00:00:00

abstract：:We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant mouse IFN-beta or saline for 7 days. Disease...

journal_title：Arthritis research & therapy

authors： van Holten J,Reedquist K,Sattonet-Roche P,Smeets TJ,Plater-Zyberk C,Vervoordeldonk MJ,Tak PP

更新日期：2004-01-01 00:00:00

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

journal_title：Arthritis research & therapy

authors： Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

更新日期：2012-04-30 00:00:00

abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

journal_title：Arthritis research & therapy

authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

更新日期：2012-01-08 00:00:00