Perforin deficiency attenuates collagen-induced arthritis.

abstract：:T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate effector cells involved in the destruction of cartilage and bone, and by contributing to osteoclast differentiation. There are murine models of arthritis, most notably collagen-...

journal_title：Arthritis research & therapy

authors： Kamradt T,Frey O

更新日期：2010-01-01 00:00:00

abstract：:Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines an...

journal_title：Arthritis research & therapy

authors： Raza K,Falciani F,Curnow SJ,Ross EJ,Lee CY,Akbar AN,Lord JM,Gordon C,Buckley CD,Salmon M

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:In cross-sectional studies, patients with rheumatoid arthritis (RA) have higher coronary artery calcium (CAC) than controls. However, their rate of progression of CAC and the predictors of CAC progression have heretofore remained unknown. METHODS:Incidence and progression of CAC were compared in 155 patie...

journal_title：Arthritis research & therapy

authors： Chung CP,Giles JT,Kronmal RA,Post WS,Gelber AC,Petri M,Szklo M,Detrano R,Budoff MJ,Blumenthal RS,Ouyang P,Bush D,Bathon JM

更新日期：2013-09-25 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory find...

journal_title：Arthritis research & therapy

authors： Sugiyama Y,Yoshimi R,Tamura M,Takeno M,Kunishita Y,Kishimoto D,Yoshioka Y,Kobayashi K,Takase-Minegishi K,Watanabe T,Hamada N,Nagai H,Tsuchida N,Soejima Y,Nakano H,Kamiyama R,Uehara T,Kirino Y,Sekiguchi A,Ihata A,O

更新日期：2018-01-11 00:00:00

abstract：INTRODUCTION:Monocytic cells play a central role in the aetiology of rheumatoid arthritis, and manipulation of the activation of these cells is an approach currently under investigation to discover new therapies for this and associated diseases. CD148 is a transmembrane tyrosine phosphatase that is highly expressed in ...

journal_title：Arthritis research & therapy

authors： Dave RK,Naylor AJ,Young SP,Bayley R,Hardie DL,Haworth O,Rider DA,Cook AD,Buckley CD,Kellie S

更新日期：2013-01-01 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

journal_title：Arthritis research & therapy

authors： Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

更新日期：2012-04-30 00:00:00

abstract：:Synovial fluid from patients with various arthritides contains procoagulant, cell-derived microparticles. Here we studied whether synovial microparticles modulate the release of chemokines and cytokines by fibroblast-like synoviocytes (FLS). Microparticles, isolated from the synovial fluid of rheumatoid arthritis (RA)...

journal_title：Arthritis research & therapy

authors： Berckmans RJ,Nieuwland R,Kraan MC,Schaap MC,Pots D,Smeets TJ,Sturk A,Tak PP

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The foot is largely overlooked in calls for better characterisation of clinical phenotypes in osteoarthritis (OA). Yet the midfoot complex in particular has the potential to provide important insights into OA pathogenesis given its central role in lower limb load transmission and alignment. Its recent incl...

journal_title：Arthritis research & therapy

authors： Thomas MJ,Peat G,Rathod T,Marshall M,Moore A,Menz HB,Roddy E

更新日期：2015-07-13 00:00:00

abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

journal_title：Arthritis research & therapy

authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. METHODS:The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory ar...

journal_title：Arthritis research & therapy

authors： Curtis JR,Chen L,Higginbotham P,Nowell WB,Gal-Levy R,Willig J,Safford M,Coe J,O'Hara K,Sa'adon R

更新日期：2017-03-07 00:00:00

abstract：INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were r...

journal_title：Arthritis research & therapy

authors： Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to examine the expression profiles of IL-29 in blood, synovial fluid (SF) and synovium in RA patients...

journal_title：Arthritis research & therapy

authors： Wang F,Xu L,Feng X,Guo D,Tan W,Zhang M

更新日期：2012-10-19 00:00:00

abstract：INTRODUCTION:Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that...

journal_title：Arthritis research & therapy

authors： Klingberg E,Lorentzon M,Göthlin J,Mellström D,Geijer M,Ohlsson C,Atkinson EJ,Khosla S,Carlsten H,Forsblad-d'Elia H

更新日期：2013-01-01 00:00:00

abstract：:Mammalian immune responses are intended to eradicate microbial pathogens and thus protect individuals from the harmful effects of such infections. However, unresolved inflammation can be devastating to the host and cause tissue damage and organ malfunction. Immune responses can even mistakenly target self-antigens and...

journal_title：Arthritis research & therapy

authors： Hu R,O'Connell RM

更新日期：2013-01-25 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：INTRODUCTION:Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of ...

journal_title：Arthritis research & therapy

authors： Dalbeth N,Pool B,Smith T,Callon KE,Lobo M,Taylor WJ,Jones PB,Cornish J,McQueen FM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent self-limiting fever and serositis that mainly affects Mediterranean populations. Many patients with FMF have been reported in Japan due to increasing recognition of this condition and the availability of ...

journal_title：Arthritis research & therapy

authors： Kishida D,Nakamura A,Yazaki M,Tsuchiya-Suzuki A,Matsuda M,Ikeda S

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targeting the 16S rRNA gene in patients with reactive and other forms of arthritis and to screen for th...

journal_title：Arthritis research & therapy

authors： Siala M,Gdoura R,Fourati H,Rihl M,Jaulhac B,Younes M,Sibilia J,Baklouti S,Bargaoui N,Sellami S,Sghir A,Hammami A

更新日期：2009-01-01 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：: ...

journal_title：Arthritis research & therapy

authors： Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

更新日期：2018-12-10 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

journal_title：Arthritis research & therapy

authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation ...

journal_title：Arthritis research & therapy

authors： Quero L,Hanser E,Manigold T,Tiaden AN,Kyburz D

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：:Joint space width (JSW) and narrowing (JSN) measurements on radiographs are currently the best way to assess disease severity or progression in hip osteoarthritis, yet we lack data regarding the most accurate and sensitive measurement technique. This study was conducted to determine the optimal radiograph and number o...

journal_title：Arthritis research & therapy

authors： Maheu E,Cadet C,Marty M,Dougados M,Ghabri S,Kerloch I,Mazières B,Spector TD,Vignon E,Lequesne MG

更新日期：2005-01-01 00:00:00

abstract：:Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect. ...

journal_title：Arthritis research & therapy

authors： Drivelegka P,Sigurdardottir V,Svärd A,Jacobsson LTH,Dehlin M

更新日期：2018-09-10 00:00:00

abstract：:Rheumatoid arthritis is a complex disease where predetermined and stochastic factors conspire to confer disease susceptibility. In light of the diverse responses to targeted therapies, rheumatoid arthritis might represent a final common clinical phenotype that reflects many pathogenic pathways. Therefore, it might be ...

journal_title：Arthritis research & therapy

authors： Firestein GS

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. METHODS:Thirty-one female subjects with OA ...

journal_title：Arthritis research & therapy

authors： Helmark IC,Mikkelsen UR,Børglum J,Rothe A,Petersen MC,Andersen O,Langberg H,Kjaer M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype. METHODS:A total of 116 RA patients and 31 ag...

journal_title：Arthritis research & therapy

authors： Fujita Y,Asano T,Matsuoka N,Temmoku J,Sato S,Matsumoto H,Furuya MY,Suzuki E,Watanabe H,Kawakami A,Migita K

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhib...

journal_title：Arthritis research & therapy

authors： Rice DA,Graven-Nielsen T,Lewis GN,McNair PJ,Dalbeth N

更新日期：2015-08-12 00:00:00