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Primary and secondary autoimmune neutropenia.

Abstract：

:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious infections and exhibits a self-limited course. Chronic idiopathic neutropenia of adults is characterized by occurrence in late childhood or adulthood, greater prevalence among females than among males, and rare spontaneous remission. Secondary AIN is more commonly seen in adults and underlying causes include collagen disorders, drugs, viruses and lymphoproliferative disorders. In most patients with AIN, antibodies recognize antigens located on the IgG Fc receptor type 3b but other target antigens have been recently identified in secondary AIN. Granulocyte colony-stimulating factor is a proven treatment in patients with AIN of all types and is now preferred to other possible therapies.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Capsoni F,Sarzi-Puttini P,Zanella A

doi

10.1186/ar1803

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

208-14

issue

5

eissn

1478-6354

issn

1478-6362

pii

ar1803

journal_volume

7

pub_type

杂志文章,评审

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