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Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus.

Abstract：

:Systematic lupus erythematosus (SLE) is a complex disease for which molecular diagnostics are limited and pathogenesis is not clearly understood. Important information is provided in this regard by identification and characterization of more specific molecular and cellular targets in SLE immune cells and target tissue and markers of early-onset and effective response to treatment of SLE complications. In recent years, advances in proteomic technologies and applications have facilitated such discoveries. Here we provide a review of insights into SLE pathogenesis, diagnosis and treatment that have been provided by mass spectrometry-based proteomic approaches.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Korte EA,Gaffney PM,Powell DW

doi

10.1186/ar3701

subject

Has Abstract

pub_date

2012-02-20 00:00:00

pages

204

issue

1

eissn

1478-6354

issn

1478-6362

pii

ar3701

journal_volume

14

pub_type

杂志文章,评审

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