An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

abstract：:In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B c...

journal_title：Arthritis research & therapy

authors： Weyand CM,Seyler TM,Goronzy JJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in gout medication use. METHODS:We analyzed annual visit and drug utilization data from national sa...

journal_title：Arthritis research & therapy

authors： Krishnan E,Chen L

更新日期：2013-11-06 00:00:00

abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

journal_title：Arthritis research & therapy

authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

更新日期：2010-01-01 00:00:00

abstract：:The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4...

journal_title：Arthritis research & therapy

authors： McCormack WJ,Parker AE,O'Neill LA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) has been known to be associated with increased risk of cardiovascular disease (CVD). The aim of this study was to investigate the effects of Tai Chi exercise on CVD risk in elderly women with RA. METHOD:In total, 56 female patients with RA were assigned to either a Tai Chi exercise...

journal_title：Arthritis research & therapy

authors： Shin JH,Lee Y,Kim SG,Choi BY,Lee HS,Bang SY

更新日期：2015-12-24 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：:Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial h...

journal_title：Arthritis research & therapy

authors： Bauer K,Knipper A,Tu-Rapp H,Koczan D,Kreutzer HJ,Nizze H,Mix E,Thiesen HJ,Holmdahl R,Ibrahim SM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis is an autoimmune arthritis characterized by joint destruction. Anti-citrullinated protein antibodies are pathologic in rheumatoid arthritis, but the role of the citrullinated proteins themselves is much less clear. Citrullination is the conversion of the arginine residues of a protein ...

journal_title：Arthritis research & therapy

authors： Shelef MA,Bennin DA,Mosher DF,Huttenlocher A

更新日期：2012-11-05 00:00:00

abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

journal_title：Arthritis research & therapy

authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

更新日期：2020-10-15 00:00:00

abstract：INTRODUCTION:The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and consequently displays an ...

journal_title：Arthritis research & therapy

authors： Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

journal_title：Arthritis research & therapy

authors： Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

更新日期：2021-01-13 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived growth factor receptor (PDGFR) activation promote collagen I (Col I) production, leading to fibrosis in SSc. Lipoic acid (LA) and its active metabolite...

journal_title：Arthritis research & therapy

authors： Tsou PS,Balogh B,Pinney AJ,Zakhem G,Lozier A,Amin MA,Stinson WA,Schiopu E,Khanna D,Fox DA,Koch AE

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

journal_title：Arthritis research & therapy

authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

更新日期：2010-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

journal_title：Arthritis research & therapy

authors： De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

更新日期：2011-01-01 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities i...

journal_title：Arthritis research & therapy

authors： Jonsson MK,Hensvold AH,Hansson M,Aga AB,Sexton J,Mathsson-Alm L,Cornillet M,Serre G,Lillegraven S,Fevang BS,Catrina AI,Haavardsholm EA

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional care is effective in improving self-care and quality of life as well as reducing rehospitalization ...

journal_title：Arthritis research & therapy

authors： Xie X,Song Y,Yang H,Nie A,Chen H,Li JP

更新日期：2018-08-16 00:00:00

abstract：INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

journal_title：Arthritis research & therapy

authors： Rutgers M,Saris DB,Dhert WJ,Creemers LB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Cardiovascular disease (CVD) is common and a major cause of mortality. Studies on cardiovascular morbidity are abundant, whereas mortality studies focusing on cardiovascular outcomes are scarce. The aim of this study was to investigate cau...

journal_title：Arthritis research & therapy

authors： Gustafsson JT,Simard JF,Gunnarsson I,Elvin K,Lundberg IE,Hansson LO,Larsson A,Svenungsson E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with different lung intercostal spaces (LIS). The purpose of this meta-analysis was to find a simplified LUS meth...

journal_title：Arthritis research & therapy

authors： Xie HQ,Zhang WW,Sun S,Chen XM,Yuan SF,Gong ZH,Liu L

更新日期：2019-04-11 00:00:00

abstract：:The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. While the debate continues about which of the involved tissues--cartilage, bone or synovium--is the most important in OA aetiology, there is no doubt...

journal_title：Arthritis research & therapy

authors： Williams FM

更新日期：2009-01-01 00:00:00

abstract：:The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta₂ glycoprotein I (anti-β₂GPI) and lupus anticoagulant (LA) assays are not only ...

journal_title：Arthritis research & therapy

authors： Meroni PL,Chighizola CB,Rovelli F,Gerosa M

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Bone morphogenetic proteins (BMPs) are critical growth factors in the osteogenic differentiation of progenitor cells during development in embryos and fracture repair in adults. Although recombinant BMPs are in use clinically, their clinical efficiency needs to be improved. The biological activities of BMP...

journal_title：Arthritis research & therapy

authors： Kwong FN,Richardson SM,Evans CH

更新日期：2008-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

journal_title：Arthritis research & therapy

authors： Moulton VR,Tsokos GC

更新日期：2011-03-17 00:00:00

abstract：:The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes. The cells were isolated from human articular cartilage obtained at surgery and were cultured in the absence or presence of ET-1 with or without inhibi...

journal_title：Arthritis research & therapy

authors： Manacu CA,Martel-Pelletier J,Roy-Beaudry M,Pelletier JP,Fernandes JC,Shipkolye FS,Mitrovic DR,Moldovan F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, both in vivo and in vitro. However, few studies have shed light on degenerative nucleus pulposus cells...

journal_title：Arthritis research & therapy

authors： Han Z,Wang J,Gao L,Wang Q,Wu J

更新日期：2018-08-16 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the disease contributing to joint damage is synovial hyperplasia. The factors responsible for the hyperplasia are u...

journal_title：Arthritis research & therapy

authors： Tu-Rapp H,Hammermüller A,Mix E,Kreutzer HJ,Goerlich R,Köhler H,Nizze H,Thiesen HJ,Ibrahim SM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

journal_title：Arthritis research & therapy

authors： Jamian L,Wheless L,Crofford LJ,Barnado A

更新日期：2019-12-30 00:00:00