Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

abstract：INTRODUCTION:Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine the protective role of carnosine (CAR) treatment in preventing these effects. METHODS:Human Col I...

journal_title：Arthritis research & therapy

authors： El-Bikai R,Welman M,Margaron Y,Côté JF,Macqueen L,Buschmann MD,Fahmi H,Shi Q,Maghni K,Fernandes JC,Benderdour M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Interleukin-1 (IL-1) blockade is the treatment of choice of cryopyrin associated periodic syndromes (CAPS). Anti-IL-1 monoclonal antibody (canakinumab) was recently registered. However no clear data are available on the optimal schedule of administration of this drug. The aim of the present study was to an...

journal_title：Arthritis research & therapy

authors： Caorsi R,Lepore L,Zulian F,Alessio M,Stabile A,Insalaco A,Finetti M,Battagliese A,Martini G,Bibalo C,Martini A,Gattorno M

更新日期：2013-02-26 00:00:00

abstract：:Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell ...

journal_title：Arthritis research & therapy

authors： Gillespie MT

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to test the naturally occurring organosulfur compound dipropyltetrasulfide (DPTTS), found in plants, which has antibiotic and anticancer properties, as a treatment for HOCl-induced systemic sclerosis in the mouse. METHODS:The prooxidative, antiproliferative, and cytotoxic effects...

journal_title：Arthritis research & therapy

authors： Marut W,Jamier V,Kavian N,Servettaz A,Winyard PG,Eggleton P,Anwar A,Nicco C,Jacob C,Chéreau C,Weill B,Batteux F

更新日期：2013-10-28 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in relation to the inflammatory activity in patients with rheumatoid arthritis (RA). METHODS:PCSK9-le...

journal_title：Arthritis research & therapy

authors： Frostegård J,Ahmed S,Hafström I,Ajeganova S,Rahman M

更新日期：2021-01-19 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) antagonists reduce the signs and symptoms of spondyloarthritides, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Our objective was to evaluate the effectiveness and safety of adalimumab, 40 mg every other week, for patients with AS or PsA and prior treatmen...

journal_title：Arthritis research & therapy

authors： Rudwaleit M,Van den Bosch F,Kron M,Kary S,Kupper H

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：INTRODUCTION:Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the share...

journal_title：Arthritis research & therapy

authors： Ferreiro-Iglesias A,Calaza M,Perez-Pampin E,Lopez Longo FJ,Marenco JL,Blanco FJ,Narvaez J,Navarro F,Cañete JD,de la Serna AR,Gonzalez-Alvaro I,Herrero-Beaumont G,Pablos JL,Balsa A,Fernandez-Gutierrez B,Caliz R,Gomez-Reino

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-α) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis (AS). ...

journal_title：Arthritis research & therapy

authors： Arends S,Spoorenberg A,Houtman PM,Leijsma MK,Bos R,Kallenberg CG,Groen H,Brouwer E,van der Veer E

更新日期：2012-04-30 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S) has been implicated in mineralization but has never been studied in OA. Here, we investigated t...

journal_title：Arthritis research & therapy

authors： Nasi S,Ehirchiou D,Chatzianastasiou A,Nagahara N,Papapetropoulos A,Bertrand J,Cirino G,So A,Busso N

更新日期：2020-03-17 00:00:00

abstract：INTRODUCTION:The foot is largely overlooked in calls for better characterisation of clinical phenotypes in osteoarthritis (OA). Yet the midfoot complex in particular has the potential to provide important insights into OA pathogenesis given its central role in lower limb load transmission and alignment. Its recent incl...

journal_title：Arthritis research & therapy

authors： Thomas MJ,Peat G,Rathod T,Marshall M,Moore A,Menz HB,Roddy E

更新日期：2015-07-13 00:00:00

abstract：INTRODUCTION:Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function. METHODS:Caspase-1 expression in rheumatoid arthritis (RA) synovial fibroblasts treated with TNF was assessed by...

journal_title：Arthritis research & therapy

authors： Marotte H,Tsou PS,Fedorova T,Pinney AJ,Lewis B,Koch AE

更新日期：2014-04-24 00:00:00

abstract：INTRODUCTION:The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS:The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of...

journal_title：Arthritis research & therapy

authors： Franklin J,Ingvarsson T,Englund M,Lohmander S

更新日期：2010-01-01 00:00:00

abstract：:The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the mid to late 1990...

journal_title：Arthritis research & therapy

authors： Boyce BF,Xing L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

journal_title：Arthritis research & therapy

authors： Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

更新日期：2021-01-13 00:00:00

abstract：INTRODUCTION:Since current treatment options for patients suffering from active rheumatoid arthritis (RA) remain inadequate, especially for those unresponsive to disease-modifying antirheumatic drugs (DMARDs), new and improved medication is needed. This study evaluates the safety and efficacy of masitinib (AB1010), a p...

journal_title：Arthritis research & therapy

authors： Tebib J,Mariette X,Bourgeois P,Flipo RM,Gaudin P,Le Loët X,Gineste P,Guy L,Mansfield CD,Moussy A,Dubreuil P,Hermine O,Sibilia J

更新日期：2009-01-01 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a me...

journal_title：Arthritis research & therapy

authors： Corallo C,Cutolo M,Kahaleh B,Pecetti G,Montella A,Chirico C,Soldano S,Nuti R,Giordano N

更新日期：2016-10-06 00:00:00

abstract：INTRODUCTION:Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share genetic and clinical features. IBD is associated with the presence of antibodies to a variety of commensal microorganisms including anti-Saccharomyces cerevesiae antibodies (ASCA), antineutrophil cytoplasmic antibodies (ANCA), anti-I2 (...

journal_title：Arthritis research & therapy

authors： Wallis D,Asaduzzaman A,Weisman M,Haroon N,Anton A,McGovern D,Targan S,Inman R

更新日期：2013-10-26 00:00:00

abstract：:Experimental arthritis models are considered valuable tools for delineating mechanisms of inflammation and autoimmune phenomena. Use of microarray-based methods represents a new and challenging approach that allows molecular dissection of complex autoimmune diseases such as arthritis. In order to characterize the temp...

journal_title：Arthritis research & therapy

authors： Rioja I,Clayton CL,Graham SJ,Life PF,Dickson MC

更新日期：2005-01-01 00:00:00

abstract：:In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflamm...

journal_title：Arthritis research & therapy

authors： Mendez-Fernandez Y,Major A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

journal_title：Arthritis research & therapy

authors： Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

更新日期：2020-12-10 00:00:00

abstract：BACKGROUND:In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to ...

journal_title：Arthritis research & therapy

authors： Esposito J,Brown Z,Stevens W,Sahhar J,Rabusa C,Zochling J,Roddy J,Walker J,Proudman SM,Nikpour M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disea...

journal_title：Arthritis research & therapy

authors： Julià A,López-Longo FJ,Pérez Venegas JJ,Bonàs-Guarch S,Olivé À,Andreu JL,Aguirre-Zamorano MÁ,Vela P,Nolla JM,de la Fuente JLM,Zea A,Pego-Reigosa JM,Freire M,Díez E,Rodríguez-Almaraz E,Carreira P,Blanco R,Taboada VM,Ló

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for physical functioning. To answer this question we...

journal_title：Arthritis research & therapy

authors： Závada J,Hánová P,Hurňáková J,Szczuková L,Uher M,Forejtová Š,Klein M,Mann H,Olejárová M,Růžičková O,Šléglová O,Hejduk K,Pavelka K

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Clinical remission can be maintained after the discontinuation of biological disease-modifying antirheumatic drugs (bDMARDs) in some patients with rheumatoid arthritis (RA) (bDMARD-free remission (BFR)). It is unknown which bDMARD is advantageous for achieving BFR or under which conditions BFR can be conside...

journal_title：Arthritis research & therapy

authors： Hashimoto M,Furu M,Yamamoto W,Fujimura T,Hara R,Katayama M,Ohnishi A,Akashi K,Yoshida S,Nagai K,Son Y,Amuro H,Hirano T,Ebina K,Uozumi R,Ito H,Tanaka M,Ohmura K,Fujii T,Mimori T

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

journal_title：Arthritis research & therapy

authors： Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

更新日期：2020-06-01 00:00:00

abstract：:Pleiotropic effects are now described for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammat...

journal_title：Arthritis research & therapy

authors： McCarey DW,Sattar N,McInnes IB

更新日期：2005-01-01 00:00:00

abstract：:The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

journal_title：Arthritis research & therapy

authors： Fritzler MJ,Wiik A,Fritzler ML,Barr SG

更新日期：2003-01-01 00:00:00