Vasculogenesis in rheumatoid arthritis.

abstract：INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were r...

journal_title：Arthritis research & therapy

authors： Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).

更新日期：2006-01-01 00:00:00

abstract：:In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by the associated high rates of psychological distress and somatisation. We address the hypothesis that the latte...

journal_title：Arthritis research & therapy

authors： McBeth J,Chiu YH,Silman AJ,Ray D,Morriss R,Dickens C,Gupta A,Macfarlane GJ

更新日期：2005-01-01 00:00:00

abstract：:Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can b...

journal_title：Arthritis research & therapy

authors： Lotz MK,Kraus VB

更新日期：2010-01-01 00:00:00

abstract：:As translational clinical researchers familiar with the risk-benefit of hematopoietic stem cell transplantation in autoimmune diseases, we are intrigued by the recent report of umbilical cord mesenchymal stem cell (UC-MSC) transplantation in treatment-refractory systemic lupus erythematosus nephritis by Wang and colle...

journal_title：Arthritis research & therapy

authors： Woodworth TG,Furst DE

更新日期：2014-07-30 00:00:00

abstract：BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

journal_title：Arthritis research & therapy

authors： Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

更新日期：2019-12-04 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

journal_title：Arthritis research & therapy

authors： Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype of RA-FLS and attenua...

journal_title：Arthritis research & therapy

authors： Pethő Z,Tanner MR,Tajhya RB,Huq R,Laragione T,Panyi G,Gulko PS,Beeton C

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are involved in IIM, and the functional relationship between autoantib...

journal_title：Arthritis research & therapy

authors： Parkes JE,Rothwell S,Day PJ,McHugh NJ,Betteridge ZE,Cooper RG,Ollier WE,Chinoy H,Lamb JA,Myositis Genetics Consortium (MYOGEN).

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:In this study, we assessed whether clinical and ultrasonography (US)-based remission could be used to select patients with rheumatoid arthritis (RA) eligible to taper and discontinue anti-TNF-α therapy after achievement of remission, looking at disease relapse. METHODS:Forty-two patients with RA in sustaine...

journal_title：Arthritis research & therapy

authors： Alivernini S,Peluso G,Fedele AL,Tolusso B,Gremese E,Ferraccioli G

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are ...

journal_title：Arthritis research & therapy

authors： Nakagawa J,Koyama Y,Kawakami A,Ueki Y,Tsukamoto H,Horiuchi T,Nagano S,Uchino A,Ota T,Akahoshi M,Akashi K

更新日期：2017-08-11 00:00:00

abstract：INTRODUCTION:Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has been well de...

journal_title：Arthritis research & therapy

authors： Mattyasovszky SG,Hofmann A,Brochhausen C,Ritz U,Kuhn S,Wollstädter J,Schulze-Koops H,Müller LP,Watzer B,Rommens PM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) patients are treated with a mean of 3-4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescription. The main reasons for change are inefficacy in 30-40 % of patients, and toxicity ≈ 10 %. Thus...

journal_title：Arthritis research & therapy

authors： Hernández-Cruz B,Márquez-Saavedra E,Caliz-Caliz R,Navarro-Sarabia F

更新日期：2016-11-08 00:00:00

abstract：:B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of c...

journal_title：Arthritis research & therapy

authors： Dörner T,Jacobi AM,Lipsky PE

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the associatio...

journal_title：Arthritis research & therapy

authors： Schipper LG,Fransen J,den Broeder AA,Van Riel PL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes. METHODS:We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in algin...

journal_title：Arthritis research & therapy

authors： Husa M,Petursson F,Lotz M,Terkeltaub R,Liu-Bryan R

更新日期：2013-01-01 00:00:00

abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

journal_title：Arthritis research & therapy

authors： Mahler M,Fritzler MJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, both in vivo and in vitro. However, few studies have shed light on degenerative nucleus pulposus cells...

journal_title：Arthritis research & therapy

authors： Han Z,Wang J,Gao L,Wang Q,Wu J

更新日期：2018-08-16 00:00:00

abstract：:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contributi...

journal_title：Arthritis research & therapy

authors： Youinou P,Pers JO

更新日期：2011-07-06 00:00:00

abstract：INTRODUCTION:Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affect patients' overall quality of life. A consensus regarding the best patient outcomes to be measur...

journal_title：Arthritis research & therapy

authors： Wallen GR,Middleton KR,Rivera-Goba MV,Mittleman BB

更新日期：2011-01-05 00:00:00

abstract：:This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alterna...

journal_title：Arthritis research & therapy

authors： Goldkind L,Simon LS

更新日期：2006-01-01 00:00:00

abstract：:Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it provides the diagnostic procedures required to asses a patient with vascul...

journal_title：Arthritis research & therapy

authors： Holle JU,Moosig F,Dalhoff K,Gross WL

更新日期：2011-06-30 00:00:00

abstract：:We analyzed the clinical response and the time to relapse after discontinuation of continuous long-term infliximab therapy in patients with ankylosing spondylitis (AS). After 3 years of infliximab therapy, all AS patients (n = 42) discontinued treatment (time point (TP)1) and were visited regularly for 1 year in order...

journal_title：Arthritis research & therapy

authors： Baraliakos X,Listing J,Brandt J,Zink A,Alten R,Burmester G,Gromnica-Ihle E,Kellner H,Schneider M,Sörensen H,Zeidler H,Rudwaleit M,Sieper J,Braun J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Factors associated with care concordant with the American College of Rheumatology (ACR) recommendations for the use of disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) are unknown. METHODS:We identified a national cohort of biologic-naive patients with RA with visits between Decem...

journal_title：Arthritis research & therapy

authors： Harrold LR,Reed GW,Kremer JM,Curtis JR,Solomon DH,Hochberg MC,Kavanaugh A,Saunders KC,Shan Y,Spruill TM,Pappas DA,Greenberg JD

更新日期：2016-04-26 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the role of hand bone mineral density (BMD) loss analyzed with digital X-ray radiogrammetry (DXR) in early rheumatoid arthritis (RA) as a predictor for progression of joint damage. METHODS:In 379 patients with early RA, baseline and one-year hand BMD was measured w...

journal_title：Arthritis research & therapy

authors： Forslind K,Kälvesten J,Hafström I,Svensson B,BARFOT Study Group.

更新日期：2012-10-15 00:00:00

abstract：INTRODUCTION:The metabolic syndrome (MetS) may contribute to the excess cardiovascular burden observed in rheumatoid arthritis (RA). The prevalence and associations of the MetS in RA remain uncertain: systemic inflammation and anti-rheumatic therapy may contribute. Methotrexate (MTX) use has recently been linked to a r...

journal_title：Arthritis research & therapy

authors： Toms TE,Panoulas VF,John H,Douglas KM,Kitas GD

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of infection. The interleukin-20 receptor (IL-20R) axis comprising IL-19, IL-20, and IL-24 and their shar...

journal_title：Arthritis research & therapy

authors： Kragstrup TW,Greisen SR,Nielsen MA,Rhodes C,Stengaard-Pedersen K,Hetland ML,Hørslev-Petersen K,Junker P,Østergaard M,Hvid M,Vorup-Jensen T,Robinson WH,Sokolove J,Deleuran B

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Desp...

journal_title：Arthritis research & therapy

authors： Lee HR,Yoo SJ,Kim J,Yoo IS,Park CK,Kang SW

更新日期：2020-05-15 00:00:00

abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

journal_title：Arthritis research & therapy

authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

更新日期：2010-01-01 00:00:00