Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling.

abstract：INTRODUCTION:Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell lines or monocytes of ...

journal_title：Arthritis research & therapy

authors： Mylona EE,Mouktaroudi M,Crisan TO,Makri S,Pistiki A,Georgitsi M,Savva A,Netea MG,van der Meer JW,Giamarellos-Bourboulis EJ,Joosten LA

更新日期：2012-07-04 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

journal_title：Arthritis research & therapy

authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of the present study was to evaluate the relationship between baseline CXCL4 level and extent of ILD i...

journal_title：Arthritis research & therapy

authors： Volkmann ER,Tashkin DP,Roth MD,Clements PJ,Khanna D,Furst DE,Mayes M,Charles J,Tseng CH,Elashoff RM,Assassi S

更新日期：2016-12-30 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：: ...

journal_title：Arthritis research & therapy

authors： Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

更新日期：2018-12-10 00:00:00

abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

journal_title：Arthritis research & therapy

authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

更新日期：2012-02-15 00:00:00

abstract：INTRODUCTION:BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recogniz...

journal_title：Arthritis research & therapy

authors： Charpin C,Martin M,Balandraud N,Roudier J,Auger I

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

journal_title：Arthritis research & therapy

authors： Lundy SK,Fox DA

更新日期：2009-01-01 00:00:00

abstract：:B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of c...

journal_title：Arthritis research & therapy

authors： Dörner T,Jacobi AM,Lipsky PE

更新日期：2009-01-01 00:00:00

abstract：:We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant mouse IFN-beta or saline for 7 days. Disease...

journal_title：Arthritis research & therapy

authors： van Holten J,Reedquist K,Sattonet-Roche P,Smeets TJ,Plater-Zyberk C,Vervoordeldonk MJ,Tak PP

更新日期：2004-01-01 00:00:00

abstract：:Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can b...

journal_title：Arthritis research & therapy

authors： Lotz MK,Kraus VB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host-pathogen interactions are involv...

journal_title：Arthritis research & therapy

authors： Jaen O,Petit-Teixeira E,Kirsten H,Ahnert P,Semerano L,Pierlot C,Cornelis F,Boissier MC,Falgarone G,European Consortium on Rheumatoid Arthritis Families.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this study was to determine the role of CRP on bon...

journal_title：Arthritis research & therapy

authors： Kim KW,Kim BM,Moon HW,Lee SH,Kim HR

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1 in human OA cartilage...

journal_title：Arthritis research & therapy

authors： Trellu S,Courties A,Jaisson S,Gorisse L,Gillery P,Kerdine-Römer S,Vaamonde-Garcia C,Houard X,Ekhirch FP,Sautet A,Friguet B,Jacques C,Berenbaum F,Sellam J

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-α) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis (AS). ...

journal_title：Arthritis research & therapy

authors： Arends S,Spoorenberg A,Houtman PM,Leijsma MK,Bos R,Kallenberg CG,Groen H,Brouwer E,van der Veer E

更新日期：2012-04-30 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：:Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of plasmacytoid dendritic cells (pDCs) by immune complexes (ICs), consisting of autoantibodies in combination with ...

journal_title：Arthritis research & therapy

authors： Rönnblom L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

journal_title：Arthritis research & therapy

authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：INTRODUCTION:Angiogenesis plays a critical role in synovial inflammation and joint destruction in rheumatoid arthritis (RA). Vascular endothelial growth factor A (VEGF-A) and angiopoietins are two important mediators of synovial angiogenesis. We have previously developed a novel chimeric decoy receptor, namely, double-...

journal_title：Arthritis research & therapy

authors： Hah YS,Koh YJ,Lim HS,Kim HO,Cheon YH,Noh HS,Jang KY,Lee SY,Lee GM,Koh GY,Lee SI

更新日期：2013-08-14 00:00:00

abstract：:Cardiovascular event rates are markedly increased in rheumatoid arthritis (RA), and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to cardiovascular disease in RA await elucidation. The present study comprises three components. First, we compared b...

journal_title：Arthritis research & therapy

authors： Dessein PH,Joffe BI,Singh S

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent self-limiting fever and serositis that mainly affects Mediterranean populations. Many patients with FMF have been reported in Japan due to increasing recognition of this condition and the availability of ...

journal_title：Arthritis research & therapy

authors： Kishida D,Nakamura A,Yazaki M,Tsuchiya-Suzuki A,Matsuda M,Ikeda S

更新日期：2014-09-27 00:00:00

abstract：:Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor precursor and extracellular matrix components such as procollagen, ...

journal_title：Arthritis research & therapy

authors： Jones GC,Riley GP

更新日期：2005-01-01 00:00:00

abstract：:This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (molecular target, isotype, registered indication for JIA, route of administration, half-life, contraindication...

journal_title：Arthritis research & therapy

authors： Swart JF,de Roock S,Wulffraat NM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we studied in detail the Flt3L/CD135 axis in RA patients. METHODS:The levels of Flt...

journal_title：Arthritis research & therapy

authors： Ramos MI,Perez SG,Aarrass S,Helder B,Broekstra P,Gerlag DM,Reedquist KA,Tak PP,Lebre MC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

journal_title：Arthritis research & therapy

authors： Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

journal_title：Arthritis research & therapy

authors： Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

更新日期：2019-12-04 00:00:00