Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach.

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：:Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell ...

journal_title：Arthritis research & therapy

authors： Gillespie MT

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significantly decreased after treatment. However, little is known about the nature of this cell entity. ...

journal_title：Arthritis research & therapy

authors： Yang HX,Zhang W,Zhao LD,Li Y,Zhang FC,Tang FL,He W,Zhang X

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. METHODS:Serum resistin levels were determin...

journal_title：Arthritis research & therapy

authors： Filková M,Hulejová H,Kuncová K,Pleštilová L,Cerezo LA,Mann H,Klein M,Zámečník J,Gay S,Vencovský J,Senolt L

更新日期：2012-05-11 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support...

journal_title：Arthritis research & therapy

authors： Sato M,Uchida K,Nakajima H,Miyazaki T,Guerrero AR,Watanabe S,Roberts S,Baba H

更新日期：2012-02-07 00:00:00

abstract：INTRODUCTION:The aims of this study were to evaluate the diagnostic accuracy of blood B-cell subset profiling and immune-system activation marker assays in primary Sjögren's syndrome (pSS) and to assess whether adding these tools to the current laboratory item would improve the American-European Consensus Group (AECG) ...

journal_title：Arthritis research & therapy

authors： Cornec D,Saraux A,Pers JO,Jousse-Joulin S,Marhadour T,Roguedas-Contios AM,Genestet S,Renaudineau Y,Devauchelle-Pensec V

更新日期：2014-01-17 00:00:00

abstract：:A growing body of literature has demonstrated that the multifunctional glycoprotein osteopontin (OPN), has a role in type I interferon (IFN) production and may be involved in systemic lupus erythematosus (SLE) pathogenesis. A recent report has provided further support for this, demonstrating an association between rai...

journal_title：Arthritis research & therapy

authors： Briggs TA

更新日期：2013-03-08 00:00:00

abstract：INTRODUCTION:The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to examine the expression profiles of IL-29 in blood, synovial fluid (SF) and synovium in RA patients...

journal_title：Arthritis research & therapy

authors： Wang F,Xu L,Feng X,Guo D,Tan W,Zhang M

更新日期：2012-10-19 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondr...

journal_title：Arthritis research & therapy

authors： Brochhausen C,Neuland P,Kirkpatrick CJ,Nüsing RM,Klaus G

更新日期：2006-01-01 00:00:00

abstract：:As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has be...

journal_title：Arthritis research & therapy

authors： Pfander D,Swoboda B,Cramer T

更新日期：2006-01-01 00:00:00

abstract：:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious in...

journal_title：Arthritis research & therapy

authors： Capsoni F,Sarzi-Puttini P,Zanella A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Rituximab (RTX) therapy of rheumatoid arthritis (RA) exhibits enhanced effectiveness in seropositive patients. Using patient sera, we tested if this improved efficacy was associated with enhanced RTX mediated complement-dependent cytotoxicity (RTX-CDC). METHODS:We developed an in vitro assay for RTX-CDC u...

journal_title：Arthritis research & therapy

authors： Jones JD,Shyu I,Newkirk MM,Rigby WF

更新日期：2013-01-25 00:00:00

abstract：BACKGROUND:Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. Cross-re...

journal_title：Arthritis research & therapy

authors： Deng H,Wang C,Chang DY,Hu N,Chen M,Zhao MH

更新日期：2017-06-06 00:00:00

abstract：:Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the present study we examined the expression and regulatory mechanisms of IFN-gamma inducible protein (IP)-10 in RA synovitis. RA synovial fluid contained greater amounts of IP-10 than did synovial fluid from patients with osteoarthr...

journal_title：Arthritis research & therapy

authors： Hanaoka R,Kasama T,Muramatsu M,Yajima N,Shiozawa F,Miwa Y,Negishi M,Ide H,Miyaoka H,Uchida H,Adachi M

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

journal_title：Arthritis research & therapy

authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensatory response that maintains the necessary resident nucleus pulposus (NP) cell proliferation to repla...

journal_title：Arthritis research & therapy

authors： Long J,Wang X,Du X,Pan H,Wang J,Li Z,Liu H,Li X,Zheng Z

更新日期：2019-10-16 00:00:00

abstract：INTRODUCTION:The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metal...

journal_title：Arthritis research & therapy

authors： Choi HM,Lee YA,Lee SH,Hong SJ,Hahm DH,Choi SY,Yang HI,Yoo MC,Kim KS

更新日期：2009-01-01 00:00:00

abstract：:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

journal_title：Arthritis research & therapy

authors： Krane SM

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered arthritis. To understand this tolerogenic mechanism, we performed a descripti...

journal_title：Arthritis research & therapy

authors： Chalise J,Narendra S,Paudyal B,Magnusson M

更新日期：2013-10-03 00:00:00

abstract：OBJECTIVE:To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). PATIENTS AND METHODS:This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose...

journal_title：Arthritis research & therapy

authors： Li R,Zhu WJ,Wang F,Tang X,Luo F

更新日期：2020-09-20 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Cardiovascular disease (CVD) is common and a major cause of mortality. Studies on cardiovascular morbidity are abundant, whereas mortality studies focusing on cardiovascular outcomes are scarce. The aim of this study was to investigate cau...

journal_title：Arthritis research & therapy

authors： Gustafsson JT,Simard JF,Gunnarsson I,Elvin K,Lundberg IE,Hansson LO,Larsson A,Svenungsson E

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus cultured under conditions of increased osmolarity. BDNF is now known to be involved in a number of biologic functions, including regula...

journal_title：Arthritis research & therapy

authors： Gruber HE,Ingram JA,Hoelscher G,Zinchenko N,Norton HJ,Hanley EN Jr

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

journal_title：Arthritis research & therapy

authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. METHODS:For this retrospective cohort analys...

journal_title：Arthritis research & therapy

authors： Grabner M,Boytsov NN,Huang Q,Zhang X,Yan T,Curtis JR

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

journal_title：Arthritis research & therapy

authors： Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

更新日期：2020-03-24 00:00:00