Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution.

abstract：INTRODUCTION:Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and ...

journal_title：Arthritis research & therapy

authors： Sellam J,Proulle V,Jüngel A,Ittah M,Miceli Richard C,Gottenberg JE,Toti F,Benessiano J,Gay S,Freyssinet JM,Mariette X

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

journal_title：Arthritis research & therapy

authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nu...

journal_title：Arthritis research & therapy

authors： TenBroek EM,Yunker L,Nies MF,Bendele AM

更新日期：2016-01-21 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious in...

journal_title：Arthritis research & therapy

authors： Capsoni F,Sarzi-Puttini P,Zanella A

更新日期：2005-01-01 00:00:00

abstract：:There is increasing recognition that central pain sensitivity plays an important role in pain severity among patients with osteoarthritis. Murphy and colleagues identified clusters of patients with osteoarthritis according to pain severity and accompanying symptoms, and one of these groups appeared to have a greater d...

journal_title：Arthritis research & therapy

authors： Allen K

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis in a cohort of Mexican Mestizo early RA patients, and to define a causal association between MetS...

journal_title：Arthritis research & therapy

authors： Parra-Salcedo F,Contreras-Yáñez I,Elías-López D,Aguilar-Salinas CA,Pascual-Ramos V

更新日期：2015-02-20 00:00:00

abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

journal_title：Arthritis research & therapy

authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：INTRODUCTION:Since current treatment options for patients suffering from active rheumatoid arthritis (RA) remain inadequate, especially for those unresponsive to disease-modifying antirheumatic drugs (DMARDs), new and improved medication is needed. This study evaluates the safety and efficacy of masitinib (AB1010), a p...

journal_title：Arthritis research & therapy

authors： Tebib J,Mariette X,Bourgeois P,Flipo RM,Gaudin P,Le Loët X,Gineste P,Guy L,Mansfield CD,Moussy A,Dubreuil P,Hermine O,Sibilia J

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

journal_title：Arthritis research & therapy

authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

更新日期：2015-04-15 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tightly orchestrated process dependent on several factors, including the balance between receptor acti...

journal_title：Arthritis research & therapy

authors： Carmona-Fernandes D,Santos MJ,Perpétuo IP,Fonseca JE,Canhão H

更新日期：2011-01-01 00:00:00

abstract：RESULTS:Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were...

journal_title：Arthritis research & therapy

authors： Pecani A,Alessandri C,Spinelli FR,Priori R,Riccieri V,Di Franco M,Ceccarelli F,Colasanti T,Pendolino M,Mancini R,Truglia S,Barbati C,Vomero M,Sabatinelli D,Morello F,Valesini G,Conti F

更新日期：2016-12-16 00:00:00

abstract：INTRODUCTION:A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, little is known about APRIL expression in RA lesions, hampering our understanding of the way APRIL may...

journal_title：Arthritis research & therapy

authors： Gabay C,Krenn V,Bosshard C,Seemayer CA,Chizzolini C,Huard B

更新日期：2009-01-01 00:00:00

abstract：:The article by Seror et al. in Arthritis Research & Therapy reports data from the 15 French patients in the open-label BELISS (Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome, NCT01160666) study of belimumab in primary Sjögren's syndrome. The study identifies that higher baseline levels of...

journal_title：Arthritis research & therapy

authors： Bowman SJ,Fisher BA

更新日期：2015-12-07 00:00:00

abstract：INTRODUCTION:An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix) was reported as highly immunogenic resulting in seroconversion in 77 to 94% of adults after administration of a single dose. The aim of the study was to investigate the impact of different anti-rheumatic treatments on antibody response to pH...

journal_title：Arthritis research & therapy

authors： Kapetanovic MC,Kristensen LE,Saxne T,Aktas T,Mörner A,Geborek P

更新日期：2014-01-02 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：:Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite...

journal_title：Arthritis research & therapy

authors： Koike T

更新日期：2011-05-31 00:00:00

abstract：INTRODUCTION:Rheumatoid synovial fibroblasts (RASFs) mediate joint inflammation and destruction in rheumatoid arthritis (RA). Endothelial protein C receptor (EPCR) is a specific receptor for the natural anticoagulant activated protein C (APC). It mediates the cytoprotective properties of APC and is expressed in rheumat...

journal_title：Arthritis research & therapy

authors： Xue M,Shen K,McKelvey K,Li J,Chan YK,Hatzis V,March L,Little CB,Tonkin M,Jackson CJ

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:The aim was to assess patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with filgotinib during two phase 2b, 24-week, randomized, placebo-controlled studies. METHODS:Patients with moderate-to-severe active RA and an inadequate response to methotrexate (MTX) were randomized ...

journal_title：Arthritis research & therapy

authors： Genovese M,Westhovens R,Meuleners L,Van der Aa A,Harrison P,Tasset C,Kavanaugh A

更新日期：2018-03-23 00:00:00

abstract：INTRODUCTION:Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhib...

journal_title：Arthritis research & therapy

authors： Rice DA,Graven-Nielsen T,Lewis GN,McNair PJ,Dalbeth N

更新日期：2015-08-12 00:00:00

abstract：INTRODUCTION:Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significantly decreased after treatment. However, little is known about the nature of this cell entity. ...

journal_title：Arthritis research & therapy

authors： Yang HX,Zhang W,Zhao LD,Li Y,Zhang FC,Tang FL,He W,Zhang X

更新日期：2009-01-01 00:00:00

abstract：:Autoantibodies to neutrophil cytoplasmic antigen-associated vasculitis (AAV) is characterised by inflammation of blood vessels. The introduction of immunosuppressive therapy with glucocorticoids and cyclophosphamide transformed AAV from a fatal condition to a largely treatable condition. Over the past 30 years, consid...

journal_title：Arthritis research & therapy

authors： Smith RM,Jones RB,Jayne DR

更新日期：2012-04-30 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：:Reports of the use of HLA-B27/peptide tetrameric complexes to study peptide-specific CD8+ T cells in HLA-B27+-related diseases are rare. To establish HLA-B27 tetramers we first compared the function of HLA-B27 tetramers with HLA-A2 tetramers by using viral epitopes. HLA-B27 and HLA-A2 tetramers loaded with immunodomin...

journal_title：Arthritis research & therapy

authors： Appel H,Kuon W,Kuhne M,Wu P,Kuhlmann S,Kollnberger S,Thiel A,Bowness P,Sieper J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of RA are largely unknown. We investigated the role of Dickkopf-related protein 1 (DKK1) produced by syn...

journal_title：Arthritis research & therapy

authors： Juarez M,McGettrick HM,Scheel-Toellner D,Yeo L,Spengler J,de Paz B,Hardy R,Cooper M,Raza K,Buckley CD,Filer A

更新日期：2016-01-19 00:00:00

abstract：INTRODUCTION:The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host-pathogen interactions are involv...

journal_title：Arthritis research & therapy

authors： Jaen O,Petit-Teixeira E,Kirsten H,Ahnert P,Semerano L,Pierlot C,Cornelis F,Boissier MC,Falgarone G,European Consortium on Rheumatoid Arthritis Families.

更新日期：2009-01-01 00:00:00