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The lung as a possible target for the immune reaction in myositis.

Abstract：

:Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the aminoacyl-tRNA synthetases and melanoma differentiation-induced gene-5 are frequently associated with interstitial lung disease. Although the mechanisms underlying these associations have not been fully elucidated, emerging data highlight the importance of autoantigen expression and conformation in the target tissue (lung and muscle, in this case), as well as identifying relevant amplifying pathways (such as regeneration).

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Danoff SK,Casciola-Rosen L

doi

10.1186/ar3347

subject

Has Abstract

pub_date

2011-07-13 00:00:00

pages

230

issue

4

eissn

1478-6354

issn

1478-6362

pii

ar3347

journal_volume

13

pub_type

杂志文章,评审

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