Abstract：
PURPOSE:The aim of this study was to assess the brain regions associated with impaired performance in a virtual, dynamic collision avoidance task, in a group of patients with homonymous visual field defects (HVFDs) because of unilateral vascular brain lesions. METHODS:Overall task performance was quantitatively assessed as the number of collisions while crossing an intersection at two levels of traffic density. Twenty-six patients were divided into two subgroups using the median split method: patients with 'performance above average' (HVFD(A), i.e. lower number of collisions) and patients with 'performance below average' (HVFD(B), i.e. higher number of collisions). In order to identify the anatomical structures that might be specifically affected in HVFD(B) patients but spared in HVFD(A) patients, overlap, subtraction and voxel-based lesion-symptom mapping analyses were performed using the MRIcron software. RESULTS:No significant difference in collision avoidance between patients with left- and right-hemispheric lesions was revealed. Separate lesion analysis in 12 patients with right- and 14 patients with left-hemispheric lesions showed that the cortical structures associated with impaired collision avoidance were the parieto-occipital region and posterior cingulate gyrus in the right hemisphere and the inferior occipital cortex and parts of the fusiform (occipito-temporal) gyrus in the left hemisphere. CONCLUSION:In the present collision avoidance paradigm, impaired performance of patients with right-hemispheric lesions is associated with damage in the dorsal processing stream and potential impact on the visual spatial working memory (WM), while impaired performance of patients with left-hemispheric lesions is associated with damage in the ventral stream and potential impact on the visual object WM.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Papageorgiou E,Hardiess G,Wiethölter H,Ackermann H,Dietz K,Mallot HA,Schiefer Udoi
10.1111/j.1755-3768.2011.02315.xsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
e198-205issue
3eissn
1755-375Xissn
1755-3768journal_volume
90pub_type
杂志文章abstract：PURPOSE:To evaluate short- and long-term intraocular pressure (IOP) changes after temporal clear corneal phacoemulsification in normal eyes. METHODS:The charts of 266 consecutive non-glaucoma patients who underwent uneventful cataract surgery were reviewed. We recorded preoperative and postoperative (1 day, 1 week, 1 ...
journal_title：Acta ophthalmologica
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abstract：PURPOSE:Monthly dosing with ranibizumab (RBZ) is needed to achieve maximal visual gains in patients with neovascular ('wet') age-related macular degeneration (wAMD). In Sweden, dosing is performed as needed (RBZ PRN), resulting in suboptimal efficacy. Intravitreal aflibercept (IVT-AFL) every 2 months after three initia...
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pub_type： 杂志文章,随机对照试验
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更新日期：2011-12-01 00:00:00
abstract：:Working at the nanoscale means to completely rethink how to approach engineering in the body in general and in the eye in particular. In nanomedicine, tissue engineering is the ability to influence an environment either by adding, subtracting or manipulating that environment to allow it to be more conducive for its pu...
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更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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doi：10.1111/j.1755-3768.2008.01184.x
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更新日期：2014-06-01 00:00:00
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更新日期：2017-09-01 00:00:00
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更新日期：2018-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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更新日期：2015-09-01 00:00:00
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pub_type：
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更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章,多中心研究
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