Abstract：
:The serotonin transporter (SERT) plays a crucial role in anxiety. Accordingly, variance in SERT functioning appears to constitute an important pathway to individual differences in anxiety. The current study tested the hypothesis that genetic variation in SERT function is associated with variability in the basic reflex physiology of defense. Healthy subjects (N=82) were presented with clearly instructed cues of shock threat and safety to induce robust anxiety reactions. Subjects carrying at least one short allele for the 5-HTTLPR polymorphism showed stronger fear-potentiated startle compared to long allele homozygotes. However, short allele carriers showed no deficit in the downregulation of fear after the offset of threat. These results suggest that natural variation in SERT function affects the magnitude of defensive reactions while not affecting the capacity for fear regulation.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Klumpers F,Heitland I,Oosting RS,Kenemans JL,Baas JMdoi
10.1016/j.biopsycho.2011.10.018subject
Has Abstractpub_date
2012-02-01 00:00:00pages
277-82issue
2eissn
0301-0511issn
1873-6246pii
S0301-0511(11)00270-5journal_volume
89pub_type
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