Concordance of mother-daughter diurnal cortisol production: Understanding the intergenerational transmission of risk for depression.

Abstract:

:A growing body of research is demonstrating concordance between mother and child diurnal cortisol production. In the context of maternal history of depression, intergenerational concordance of cortisol production could contribute to hypercortisolemia in children of depressed mothers, which has been shown to increase risk for MDD. The current study is the first to examine concordance in diurnal cortisol production between mothers with a history of depression and their never-depressed, but high-risk, children. We collected salivary cortisol across 2 days from mothers with (remitted; RMD) and without (CTL) a history of recurrent episodes of depression and their never-depressed daughters. As expected, RMD mothers and their daughters both exhibited higher cortisol production than did their CTL counterparts. Moreover, both across and within groups, mothers' and daughters' cortisol production were directly coupled. These findings suggest that there is an intergenerational concordance in cortisol dysregulation that may contribute to hypercortisolemia in girls at familial risk for depression.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

LeMoult J,Chen MC,Foland-Ross LC,Burley HW,Gotlib IH

doi

10.1016/j.biopsycho.2015.03.019

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

98-104

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(15)00084-8

journal_volume

108

pub_type

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