Individual differences in the processing of smoking-cessation video messages: An imaging genetics study.

Abstract:

:Studies testing the benefits of enriching smoking-cessation video ads with attention-grabbing sensory features have yielded variable results. Dopamine transporter gene (DAT1) has been implicated in attention deficits. We hypothesized that DAT1 polymorphism is partially responsible for this variability. Using functional magnetic resonance imaging, we examined brain responses to videos high or low in attention-grabbing features, indexed by "message sensation value" (MSV), in 53 smokers genotyped for DAT1. Compared to other smokers, 10/10 homozygotes showed greater neural response to High- vs. Low-MSV smoking-cessation videos in two a priori regions of interest: the right temporoparietal junction and the right ventrolateral prefrontal cortex. These regions are known to underlie stimulus-driven attentional processing. Exploratory analysis showed that the right temporoparietal response positively predicted follow-up smoking behavior indexed by urine cotinine. Our findings suggest that responses to attention-grabbing features in smoking-cessation messages is affected by the DAT1 genotype.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

Shi Z,Wang AL,Aronowitz CA,Romer D,Langleben DD

doi

10.1016/j.biopsycho.2017.07.019

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

125-131

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(17)30138-2

journal_volume

128

pub_type

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