Natural and synthetic sex hormones: effects on higher-order cognitive function and prepulse inhibition.

Abstract:

:Little is known about the effects of the commonly-used oral contraceptive pill (OC) on cognition. This study compared matched healthy women across the menstrual cycle (early-follicular 'Low E/P', mid-luteal 'High E/P'), women using the combined OC, and men. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to assess immediate and delayed memory, visuospatial ability, language and attention. Assessment of prepulse inhibition (PPI) included 21 pulse-alone trials (115dB) and 42 prepulse-pulse trials (74, 78, 86dB). The OC and High E/P groups outperformed men on the total RBANS score, an overall measure of cognition. For the immediate memory/learning and attention domains, the OC group outperformed men; for the delayed memory domain, the OC and High E/P groups outperformed men. In conclusion, high levels of natural or synthetic sex hormones had a positive effect on higher-order cognition but had little effect on baseline PPI.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

Gogos A

doi

10.1016/j.biopsycho.2013.02.001

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

17-23

issue

1

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(13)00029-X

journal_volume

93

pub_type

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