Abstract：
:Subjects with low/undetectable startle are usually excluded from startle studies but few reports not confounded by this factor, show reduced startle in healthy impulsive subjects, or clinical populations with disorders of affect and impulsivity but also in schizophrenia and its prodrome. We examined the relationship of startle reactivity including startle "non-responding" status to cognitive and affective personality traits in a large and ethnically/demographically homogeneous cohort of healthy males from the LOGOS study, Heraklion, Crete. Startle reactivity was monotonically related to sensitivity to reward (higher in "non-responders", lower in strong responders). In addition, "non-responders" had poorer strategy, working memory and sustained attention performance compared to responder tertile groups. More research in clinical and high risk populations is required to examine if low/undetectable startle reactivity is a valuable intermediate phenotype for disorders of affect and impulsivity. It is possible that the "non-responsive" status may capture disease related features such as executive dysfunction.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Giakoumaki SG,Roussos P,Tsapakis EM,Koiliari E,Pasparakis E,Zouraraki C,Bitsios Pdoi
10.1016/j.biopsycho.2013.09.005subject
Has Abstractpub_date
2013-12-01 00:00:00pages
582-91issue
3eissn
0301-0511issn
1873-6246pii
S0301-0511(13)00196-8journal_volume
94pub_type
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