Abstract:
:The epidemiology of meningococcal disease in Europe since 1945 has shown fluctuations in incidence, serogroup distribution and case-fatality rate. Outbreaks and epidemics driven by the introduction of new virulent strains into Europe have occurred unpredictably. Epidemics associated with serogroups A and B have occurred in all regions of the continent. Additionally, there have been periods of increased outbreak frequency, such as those associated with serogroup C in the 1980s and 1990s, against an endemic disease incidence of around one to two cases per 100,000 population. Serogroup W135 disease was observed in the 1970s and again in 2000, while serogroup Y has recently emerged in Sweden and the Czech Republic. This article describes the changing epidemiology of meningococcal disease in Europe. An understanding of this is important for informed decision-making about different meningococcal vaccines that may be considered for use in Europe.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Kriz P,Wieffer H,Holl K,Rosenlund M,Budhia S,Vyse Adoi
10.1586/erv.11.117subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1477-86issue
10eissn
1476-0584issn
1744-8395journal_volume
10pub_type
历史文章,杂志文章,评审abstract::Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.24
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abstract::The aging process in humans is associated with a decrease in immune function (immunosenescence) and an increase in comorbid disorders. When combined with environmental factors this can lead to an increased risk and severity of infectious diseases. Diseases in older adults (>/=70 years) tend to be more severe and have ...
journal_title:Expert review of vaccines
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abstract::This review deals with specific immunotherapy performed with pollen vaccines. Pollen allergens, the immunological mechanism of allergic inflammation and the mechanisms behind successful specific immunotherapy treatment of seasonal pollen allergy shall be discussed. The different approaches to develop improved regimes ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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abstract::In addition to the use of traditional vaccines in the National Immunization Program, the introduction: of additional vaccines in Indonesia appears to be important to further reduce rates of childhood mortality. However, it typically takes at least two decades for additional vaccines to be introduced into the National ...
journal_title:Expert review of vaccines
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abstract:OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...
journal_title:Expert review of vaccines
pub_type: 杂志文章,随机对照试验
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abstract::Atherosclerosis is the primary cause of acute myocardial infarction and stroke. It is well established that arterial inflammation in response to accumulation and oxidation of lipoproteins in the vascular wall is the major factor responsible for the development of atherosclerosis. During recent years, it has become app...
journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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abstract::With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...
journal_title:Expert review of vaccines
pub_type: 历史文章,杂志文章,评审
doi:10.1586/14760584.2013.811188
更新日期:2013-07-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1417044
更新日期:2018-01-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.41
更新日期:2010-06-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.09.113
更新日期:2009-11-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.1005
更新日期:2008-09-01 00:00:00
abstract::Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 社论
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更新日期:2014-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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更新日期:2013-06-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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