T-cell immunity generated by recombinant adenovirus vaccines.

abstract：:In recent years, considerable data has been provided to support the role of the immune system in atherosclerosis. These reports came from studies involving knockout murine models of atherosclerosis and human subjects. The notion that inflammatory mechanisms are operable in atherogenesis has fueled a series of studies ...

journal_title：Expert review of vaccines

authors： Harats D,George J

更新日期：2004-10-01 00:00:00

abstract：:Evaluation of: Böckl K, Wild J, Bredl S et al. Altering an artificial Gagpolnef polyprotein and mode of Env co-administration affects the immunogenicity of a clade C HIV-1 DNA vaccine. PLoS ONE 7(4), e34723 (2012). SIV vaccination studies in monkeys have revealed that Env-directed antibodies are critical for protect...

journal_title：Expert review of vaccines

authors： van Montfort T,Sanders RW

更新日期：2012-10-01 00:00:00

abstract：:Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...

journal_title：Expert review of vaccines

authors： Epstein SL,Price GE

更新日期：2010-11-01 00:00:00

abstract：:Atherosclerosis is the primary cause of acute myocardial infarction and stroke. It is well established that arterial inflammation in response to accumulation and oxidation of lipoproteins in the vascular wall is the major factor responsible for the development of atherosclerosis. During recent years, it has become app...

journal_title：Expert review of vaccines

authors： Nilsson J,Wigren M,Shah PK

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...

journal_title：Expert review of vaccines

authors： Robertson CA,DiazGranados CA,Decker MD,Chit A,Mercer M,Greenberg DP

更新日期：2016-12-01 00:00:00

abstract：:Combination vaccines have been used for many years in the USA as part of the primary infant immunization series. However, the current program still requires up to 24 injections by 18 months of age. The Advisory Committee on Immunization Practices in the USA recommends the use of combination vaccines whenever possible....

journal_title：Expert review of vaccines

authors： White C,Halperin SA,Scheifele DW

更新日期：2009-07-01 00:00:00

abstract：:There is growing interest in immunotherapy for malignant gliomas. This interest stems from a number of immunological observations, together with the failure of conventional therapeutic agents to produce broad and clinically meaningful improvements in survival and quality of life. The challenges faced in translating la...

journal_title：Expert review of vaccines

authors： Fenstermaker RA,Ciesielski MJ

更新日期：2014-03-01 00:00:00

abstract：:Aluminum-containing adjuvants are an important component of many vaccines because they safely potentiate the immune response. The structure and properties of aluminum hydroxide adjuvant, aluminum phosphate adjuvant and alum-precipitated adjuvants are presented in this review. The major antigen adsorption mechanisms, e...

journal_title：Expert review of vaccines

authors： Hem SL,Hogenesch H

更新日期：2007-10-01 00:00:00

abstract：:In the molecular farming area, transient expression approaches for pharmaceutical proteins production, mainly recombinant monoclonal antibodies and vaccines, were developed almost two decades ago and, to date, these systems basically depend on Agrobacterium-mediated delivery and virus expression machinery. We survey h...

journal_title：Expert review of vaccines

authors： Komarova TV,Baschieri S,Donini M,Marusic C,Benvenuto E,Dorokhov YL

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Meningococcal disease has an incidence peak spread over several years during adolescence and young adulthood in the United States. Meningococcal serogroup B (MenB) vaccines have been introduced relatively recently and may help protect individuals in these age groups. Currently there is insufficient long-te...

journal_title：Expert review of vaccines

authors： Watson PS,Novy P,Bekkat-Berkani R,Strubbe F,Banzhoff A

更新日期：2019-04-01 00:00:00

abstract：:Notifications of infant deaths, assumed to be related to the introduction of new pentavalent DTwP-Hib-HBV childhood vaccines, caused, during 2008-2010 in few Asian countries, temporary interruptions of the respective vaccination programs. The sudden appearance of fatal cases was due to increased awareness/publicity an...

journal_title：Expert review of vaccines

authors： Herzog C

更新日期：2015-01-01 00:00:00

abstract：:The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of per...

journal_title：Expert review of vaccines

authors： Warfel JM,Merkel TJ

更新日期：2014-10-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait. METHODS:Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 f...

journal_title：Expert review of vaccines

authors： Mokaddas E,Albert MJ

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Although much progress has been made in the last decade(s) toward development of effective cancer vaccines, there are still important obstacles to therapeutic successes. New generations of cancer vaccines will benefit from a combination adjuvant approach that targets multiple branches of the immune respons...

journal_title：Expert review of vaccines

authors： Bowen WS,Svrivastava AK,Batra L,Barsoumian H,Shirwan H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Despite high 1-dose vaccination coverage, breakthrough varicella infections still occur. Therefore, 2-dose vaccination is recommended to enhance the immune response to the virus. However, the reported incremental vaccine effectiveness (VE) of 2-dose vaccination varies widely among studies. METHODS:To determ...

journal_title：Expert review of vaccines

authors： Yin M,Xu X,Liang Y,Ni J

更新日期：2018-04-01 00:00:00

abstract：:Lassa virus (LASV) is the most prevalent arenavirus in West Africa and is responsible for several hundred thousand infections and thousands of deaths annually. The sizeable disease burden, numerous imported cases of Lassa fever (LF) and the possibility that LASV can be used as an agent of biological warfare make a str...

journal_title：Expert review of vaccines

authors： Lukashevich IS

更新日期：2013-01-01 00:00:00

abstract：:The approval of sipuleucel-T has placed cancer vaccines on the verge of becoming an effective modality. However, there is much to define to understand the intricacies from the multiple confounding factors in vaccine immunotherapy. In this article under review, some patients with metastatic cancer who had limited tumor...

journal_title：Expert review of vaccines

authors： Baxevanis CN

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Intranasal influenza vaccines are expected to confer protection among vaccine recipients by successful induction of mucosal immune response in the upper respiratory tract. Though only live attenuated influenza virus vaccines (LAIVs) are licensed and available for intranasal use in humans today, intranasal ...

journal_title：Expert review of vaccines

authors： Sano K,Ainai A,Suzuki T,Hasegawa H

更新日期：2018-08-01 00:00:00

abstract：:Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control...

journal_title：Expert review of vaccines

authors： Vici P,Pizzuti L,Mariani L,Zampa G,Santini D,Di Lauro L,Gamucci T,Natoli C,Marchetti P,Barba M,Maugeri-Saccà M,Sergi D,Tomao F,Vizza E,Di Filippo S,Paolini F,Curzio G,Corrado G,Michelotti A,Sanguineti G,Giordano A

更新日期：2016-10-01 00:00:00

abstract：:The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...

journal_title：Expert review of vaccines

authors： Langley JM,Naus M

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Serra L,Safadi MAP

更新日期：2020-04-01 00:00:00

abstract：:Incredibly, vaccines currently capture only about 2% of the world's pharmaceutical market, despite the fact that they can be credited with saving more lives and preventing more suffering and disability than any other form of medical activity, with the possible exception of the provision of clean water. ...

journal_title：Expert review of vaccines

authors： Andre FE

更新日期：2005-02-01 00:00:00

abstract：:Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...

journal_title：Expert review of vaccines

authors： Schijns VE,Lavelle EC

更新日期：2011-04-01 00:00:00

abstract：:Therapeutic prospects of particulates are increasingly recognized for vaccination purposes. Compared with biologic particulates, such as live or attenuated bacterial vectors and viral vectors, synthetic particulates may be expected to ease the hurdles of quality assurance and validation in vaccine development and prod...

journal_title：Expert review of vaccines

authors： Thiele L,Merkle HP,Walter E

更新日期：2002-08-01 00:00:00

abstract：:Efforts to develop a meningococcal vaccine that will include coverage against serogroup B disease have largely focused on outer membrane protein antigens. The protection offered by currently licensed outer membrane vesicle (OMV) vaccines is specific to epidemic strains as their immunodominant antigens are highly varia...

journal_title：Expert review of vaccines

authors： Sanders H,Feavers IM

更新日期：2011-03-01 00:00:00

abstract：:Pneumococcal disease is a major health problem worldwide. Large, rapid declines in overall invasive pneumococcal disease and mucosal disease in children, reductions in vaccine-type disease in unvaccinated children and adults (indirect effects) and significant drops in antibiotic-resistant infections were observed afte...

journal_title：Expert review of vaccines

authors： Dinleyici EC,Yargic ZA

更新日期：2008-11-01 00:00:00

abstract：:Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...

journal_title：Expert review of vaccines

authors： Wheatley AK,Kent SJ

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...

journal_title：Expert review of vaccines

authors： Kilpeläinen A,Maya-Hoyos M,Saubí N,Soto CY,Joseph Munne J

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a globally prevalent disease despite remaining susceptible to penicillin treatment. Syphilis vaccine development is a viable preventative approach that will serve to complement public health-oriented syphilis prevent...

journal_title：Expert review of vaccines

authors： Lithgow KV,Cameron CE

更新日期：2017-01-01 00:00:00